| URN | urn:agi-llid:9372 |
|---|---|
| Total Entities | 0 |
| Connectivity | 124 |
| Name | ZFYVE9 |
| Description | zinc finger, FYVE domain containing 9 (predicted) |
| Notes | This gene encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this gene. |
| GO Molecular Function | serine-type peptidase activity |
|---|---|
| SMAD binding | |
| 1-phosphatidylinositol binding | |
| metal ion binding |
| GO Cellular Component | early endosome membrane |
|---|---|
| cytoplasm | |
| early endosome |
| GO Biological Process | negative regulation of transforming growth factor beta receptor signaling pathway |
|---|---|
| regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| SMAD protein complex assembly | |
| SMAD protein import into nucleus | |
| endocytosis |
| Pathway | transforming growth factor-beta Smad dependent signaling pathway |
|---|---|
| transforming growth factor-beta Smad dependent signaling pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway | |
| transforming growth factor-beta Smad dependent signaling pathway |
| Group | negative regulation of transforming growth factor beta receptor signaling pathway |
|---|---|
| regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| SMAD protein complex assembly | |
| SMAD protein import into nucleus | |
| serine-type peptidase activity | |
| endocytosis | |
| SMAD binding | |
| 1-phosphatidylinositol binding | |
| metal ion binding | |
| early endosome membrane | |
| cytoplasm | |
| early endosome |
| Source | Curated |
|---|
| LocusLink ID | 9372 |
|---|---|
| 230597 | |
| 313477 |
| Cell Localization | Cytoplasm |
|---|---|
| Early endosome membrane |
| GO ID | 0005545 |
|---|---|
| 0046872 | |
| 0008236 | |
| 0007183 | |
| 0007184 | |
| 0006897 | |
| 0030512 | |
| 0007179 | |
| 0005737 | |
| 0005769 | |
| 0031901 | |
| 0046332 | |
| 0017015 | |
| 0005515 | |
| 0004872 | |
| 0008270 | |
| 0007181 |
| Alias | NSP |
|---|---|
| SARA | |
| MADHIP | |
| SMADIP | |
| zinc finger FYVE domain-containing protein 9 | |
| novel serine protease | |
| MADH-interacting protein | |
| smad anchor for receptor activation | |
| MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor | |
| E030027L17 | |
| RP23-406B13.8 | |
| zinc finger, FYVE domain containing IX | |
| OTTMUSP00000008607 | |
| OTTMUSP00000032178 | |
| OTTMUSP00000032179 | |
| Receptor activating anchor | |
| Receptor activation anchor | |
| zinc finger, FYVE domain containing 9 | |
| MADH interacting protein | |
| OTTHUMP00000009741 | |
| ZFYVE9 | |
| LOC230597 | |
| OTTHUMP00000009740 | |
| hSARA | |
| LOC277733 | |
| LOC381539 | |
| MAD (mothers against decapentaplegic, Drosophila) homolog interacting prote | |
| MAD homolog interacting protein | |
| OTTHUMP00000009739 | |
| MADH-interactive protein | |
| Mothers against decapentaplegic homolog interacting protein | |
| Mothers against decapentaplegic homolog interactive protein | |
| MAD, mothers against decapentaplegic homolog interacting prote | |
| AK087111 | |
| mothers against decapentaplegic homolog (Drosophila) interacting protein | |
| MAD, mothers against decapentaplegic homolog (Drosophila) interacting protein, receptor activation anchor | |
| Madh- interacting protein | |
| MAD, mothers against decapentaplegic homolog interacting prote | |
| hypothetical protein LOC230597 | |
| Madh- interactive protein | |
| Receptor activating anchor | |
| Receptor activation anchor | |
| ZFYVE9s | |
| zinc finger, FYVE domain containing 9 (predicted) |
| Mouse chromosome position | 4 |
|---|---|
| 4 C7 |
| OMIM ID | 603755 |
|---|
| Rat chromosome position | 5q35 |
|---|
| Hugo ID | 6775 |
|---|
| Human chromosome position | 1p32.3 |
|---|
| Swiss-Prot Accession | O95405 |
|---|---|
| A0S860 | |
| Q5T0F6 | |
| Q5T0F7 | |
| Q9UNE1 | |
| Q9Y5R7 | |
| Q59GI4 | |
| Q8C333 |
| Unigene ID | Hs.532345 |
|---|---|
| Mm.196776 | |
| Rn.23612 |
| KEGG ID | hsa:9372 |
|---|---|
| mmu:230597 | |
| rno:313477 |
| Swiss-Prot ID | ZFYV9_HUMAN |
|---|
| Ensembl ID | ENSG00000157077 |
|---|---|
| ENSP00000287727 | |
| ENST00000287727 | |
| ENSP00000349737 | |
| ENST00000357206 | |
| ENSMUSG00000034557 | |
| ENSMUSP00000039852 | |
| ENSMUST00000042185 | |
| ENSMUSP00000102269 | |
| ENSMUST00000106658 | |
| ENSMUSP00000102268 | |
| ENSMUST00000106657 | |
| ENSRNOG00000027183 | |
| ENSRNOP00000036295 | |
| ENSRNOT00000037523 |
| Homologene ID | 3527 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2652838 |
|---|
| RGD ID | 1310856 |
|---|
| MedScan ID | 9372 |
|---|