| URN | urn:agi-llid:4087 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1833 |
| Name | SMAD2 |
| Description | MAD homolog 2 (Drosophila) |
| Notes | transcriptional mediator for both activin and TGFbeta [RGD] |
| GO Molecular Function | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
|---|---|
| sequence-specific DNA binding transcription factor activity | |
| chromatin binding | |
| SMAD binding | |
| transcription factor binding | |
| activating transcription factor binding | |
| transforming growth factor beta receptor binding | |
| type I transforming growth factor beta receptor binding | |
| phosphatase binding | |
| ubiquitin protein ligase binding | |
| co-SMAD binding | |
| I-SMAD binding | |
| R-SMAD binding | |
| DNA binding | |
| double-stranded DNA binding | |
| metal ion binding |
| GO Cellular Component | cell |
|---|---|
| nucleoplasm | |
| activin responsive factor complex | |
| protein complex | |
| transcription factor complex | |
| SMAD protein complex | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | primary miRNA processing |
|---|---|
| post-embryonic development | |
| organ growth | |
| pattern specification process | |
| embryonic pattern specification | |
| zygotic specification of dorsal-ventral axis | |
| anterior-posterior pattern specification | |
| positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left-right asymmetry | |
| embryonic cranial skeleton morphogenesis | |
| ureteric bud development | |
| lung development | |
| pancreas development | |
| heart development | |
| pericardium development | |
| positive regulation of epithelial to mesenchymal transition | |
| embryonic foregut morphogenesis | |
| in utero embryonic development | |
| gastrulation | |
| endoderm formation | |
| mesoderm formation | |
| developmental growth | |
| cell fate commitment | |
| paraxial mesoderm morphogenesis | |
| signal transduction involved in regulation of gene expression | |
| intracellular signal transduction | |
| positive regulation of BMP signaling pathway | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| common-partner SMAD protein phosphorylation | |
| SMAD protein complex assembly | |
| activin receptor signaling pathway | |
| nodal signaling pathway | |
| insulin secretion | |
| negative regulation of cell proliferation | |
| response to glucose | |
| response to cholesterol | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-templated | |
| palate development | |
| endoderm development | |
| transcription, DNA-templated | |
| transcription initiation from RNA polymerase II promoter | |
| protein phosphorylation | |
| gene expression | |
| regulation of binding |
| Pathway | Cell Cycle |
|---|---|
| Prostate Cancer Overview | |
| Metastatic Colorectal Cancer Overview | |
| Role of Myostatin in Skeletal Muscles | |
| Myostatin-IGF1 Crosstalk in Skeletal Muscles | |
| Chronic Myeloid Leukemia Overview | |
| Hodgkin Lymphoma Overview | |
| Diffuse Large-B-cell Lymphoma Overview | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to IGF1R/Akt Signaling Pathway | |
| Breast Cancer Related to NOTCH1 Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to NOTCH Signaling Pathway | |
| Basal Breast Cancer | |
| Ovarian Cancer Overview | |
| Activation of Immunoglobulin Class-Switch Recombination | |
| Cancer Overview | |
| Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy | |
| Hypertrophic Cardiomyopathy Overview | |
| Impairment of BMP and TGF-beta Signaling in Familial and Idiopathic Pulmonary Arterial Hypertension | |
| Activation of Glioma Stem Cell Program | |
| Medulloblastoma Overview | |
| Impaired TGFB2 Signaling in Osteoarthritis | |
| Osteoarthritis Overview | |
| STK11 Signaling in Pancreatic Cancer | |
| TGFBR Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Pancreatic Neuroendocrine Tumors | |
| Peutz-Jeghers Syndrome Overview | |
| Growth Factor Signaling in Hepatocellular Carcinoma | |
| NOTCH Signaling in Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| Vascularization in Hepatocellular Carcinoma | |
| Impaired Osteoblast Function in Gout | |
| Synovial Fibroblast Proliferation in Rheumatoid Arthritis | |
| Mechanism of Skin Fibrosis in Systemic Scleroderma | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| ActivinR -> SMAD2/3 signaling | |
| TGFBR/BMPR -> SMAD2/3 signaling | |
| Dexamethasone-Induced Osteoporosis | |
| BMP7-ACVR2 Expression Targets | |
| INHBA-ACVR2/ACVR1 Expression Targets | |
| MSTN-ACVR2/ACVR1 Expression Targets | |
| INHBB-ACVR2 Expression Target | |
| BMP6-ACVR2A Expression Targets | |
| NODAL-ACVR2B Expression Targets | |
| TGFB2-TGFBR1 Expression Targets | |
| TGFB3-TGFBR1 Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway | |
| transforming growth factor-beta Smad dependent signaling pathway |
| Group | SMAD |
|---|---|
| Tumor suppressors | |
| primary miRNA processing | |
| post-embryonic development | |
| organ growth | |
| pattern specification process | |
| embryonic pattern specification | |
| zygotic specification of dorsal-ventral axis | |
| anterior-posterior pattern specification | |
| positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left-right asymmetry | |
| embryonic cranial skeleton morphogenesis | |
| ureteric bud development | |
| lung development | |
| pancreas development | |
| heart development | |
| pericardium development | |
| positive regulation of epithelial to mesenchymal transition | |
| embryonic foregut morphogenesis | |
| in utero embryonic development | |
| gastrulation | |
| endoderm formation | |
| mesoderm formation | |
| developmental growth | |
| cell fate commitment | |
| paraxial mesoderm morphogenesis | |
| signal transduction involved in regulation of gene expression | |
| intracellular signal transduction | |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | |
| positive regulation of BMP signaling pathway | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| common-partner SMAD protein phosphorylation | |
| SMAD protein complex assembly | |
| activin receptor signaling pathway | |
| nodal signaling pathway | |
| insulin secretion | |
| negative regulation of cell proliferation | |
| response to glucose | |
| response to cholesterol | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-templated | |
| sequence-specific DNA binding transcription factor activity | |
| palate development | |
| endoderm development | |
| transcription, DNA-templated | |
| transcription initiation from RNA polymerase II promoter | |
| protein phosphorylation | |
| gene expression | |
| regulation of binding | |
| chromatin binding | |
| SMAD binding | |
| transcription factor binding | |
| activating transcription factor binding | |
| transforming growth factor beta receptor binding | |
| type I transforming growth factor beta receptor binding | |
| phosphatase binding | |
| ubiquitin protein ligase binding | |
| co-SMAD binding | |
| I-SMAD binding | |
| R-SMAD binding | |
| DNA binding | |
| double-stranded DNA binding | |
| metal ion binding | |
| cell | |
| nucleoplasm | |
| activin responsive factor complex | |
| protein complex | |
| transcription factor complex | |
| SMAD protein complex | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| LocusLink ID | 4087 |
|---|---|
| 17126 | |
| 29357 | |
| 319898 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| GO ID | 0003677 |
|---|---|
| 0070411 | |
| 0070412 | |
| 0046332 | |
| 0033613 | |
| 0003682 | |
| 0070410 | |
| 0003690 | |
| 0046872 | |
| 0019902 | |
| 0003700 | |
| 0008134 | |
| 0005160 | |
| 0030618 | |
| 0034713 | |
| 0031625 | |
| 0007183 | |
| 0032924 | |
| 0009952 | |
| 0045165 | |
| 0007182 | |
| 0048589 | |
| 0048701 | |
| 0048617 | |
| 0001706 | |
| 0007369 | |
| 0010467 | |
| 0001701 | |
| 0030073 | |
| 0035556 | |
| 0030324 | |
| 0001707 | |
| 0008285 | |
| 0000122 | |
| 0045892 | |
| 0030512 | |
| 0038092 | |
| 0035265 | |
| 0060021 | |
| 0031016 | |
| 0048340 | |
| 0060039 | |
| 0030513 | |
| 0010718 | |
| 1900224 | |
| 0045944 | |
| 0045893 | |
| 0009791 | |
| 0031053 | |
| 0051098 | |
| 0017015 | |
| 0070723 | |
| 0009749 | |
| 0006367 | |
| 0006351 | |
| 0007179 | |
| 0001657 | |
| 0007352 | |
| 0071141 | |
| 0032444 | |
| 0005737 | |
| 0005829 | |
| 0005654 | |
| 0005634 | |
| 0005667 | |
| 0009880 | |
| 0007492 | |
| 0007507 | |
| 0007389 | |
| 0006468 | |
| 0006355 | |
| 0023019 | |
| 0005623 | |
| 0005622 | |
| 0043234 | |
| 0010843 | |
| 0016563 | |
| 0023034 | |
| 0043193 | |
| 0045941 | |
| 0045449 | |
| 0006350 | |
| 0007242 | |
| 0042301 | |
| 0043130 | |
| 0005515 | |
| 0009887 | |
| 0007165 |
| Alias | JV18 |
|---|---|
| MADH2 | |
| MADR2 | |
| JV18-1 | |
| hMAD-2 | |
| hSMAD2 | |
| mothers against decapentaplegic homolog 2 | |
| MAD homolog 2 | |
| mother against DPP homolog 2 | |
| Sma- and Mad-related protein 2 | |
| SMAD, mothers against DPP homolog 2 | |
| mMad2 | |
| Smad-2 | |
| 7120426M23Rik | |
| Smad 2 | |
| mad-related protein 2 | |
| mothers against DPP homolog 2 | |
| Mothers against decapentaplegic, Drosophila, homolog of, 2 | |
| Mothers against decapentaplegic homolog II | |
| MGC22139 | |
| MGC34440 | |
| Mothers against decapentaplegic, Drosophila, homolog of, II | |
| Smad2 transcription factor | |
| RIKEN cDNA 7120426M23 gene | |
| Mothers against DPP homolog II | |
| SMAD, mothers against DPP homolog II | |
| transcription factor Smad2 | |
| 7120426M23 | |
| MAD, mothers against decapentaplegic homolog 2 (Drosophila) | |
| MGC156656 | |
| Mad-related protein II | |
| hMAD II | |
| hMAD IIs | |
| homolog of Drosophila Mothers against decapentaplegic,, II | |
| JV18 I | |
| LOC653804 | |
| MAD homolog II | |
| homolog of Drosophila Mothers against decapentaplegic,, 2 | |
| LOC654050 | |
| MAD homolog 2 (Drosophila) | |
| MAD (mothers against decapentaplegic, Drosophila) homolog II | |
| MAD (mothers against decapentaplegic homolog II | |
| MAD (mothers against decapentaplegic homolog 2 | |
| MAD (mothers against decapentaplegic Drosophila) homolog 2 | |
| Mad protein homolog | |
| MAD, mothers against decapentaplegic homolog 2 | |
| SMAD family member 2 | |
| SMAD2 | |
| Mothers against DPP homolog II | |
| MAD (mothers against decapentaplegic, Drosophila) homolog 2 | |
| Mothers against DPP homolog 2 | |
| JV18 Is | |
| JV18-1s | |
| similar to smad |
| Mouse chromosome position | 18 51.42 cM |
|---|---|
| 18 48.0 cM |
| OMIM ID | 601366 |
|---|
| Rat chromosome position | 18q12.3 |
|---|
| Hugo ID | 6768 |
|---|
| Human chromosome position | 18q21.1 |
|---|
| Swiss-Prot Accession | Q15796 |
|---|---|
| Q53XR6 | |
| B7Z5N5 | |
| Q62432 | |
| O70436 | |
| Q6GU18 | |
| Q6VP00 | |
| Q9D8P6 | |
| A0JPM1 | |
| Q7Z5E4 | |
| Q8C2P1 |
| PIR ID | S71797 |
|---|
| Unigene ID | Hs.12253 |
|---|---|
| Hs.705764 | |
| Hs.741342 | |
| Mm.152699 | |
| Mm.490934 | |
| Rn.2755 | |
| Mm.391091 | |
| Hs.598146 |
| KEGG ID | hsa:4087 |
|---|---|
| mmu:17126 | |
| rno:29357 |
| Swiss-Prot ID | SMAD2_MOUSE |
|---|---|
| SMAD2_RAT | |
| SMAD2_HUMAN | |
| Q53XR6_HUMAN |
| Ensembl ID | ENSG00000175387 |
|---|---|
| ENSP00000384449 | |
| ENST00000402690 | |
| ENSP00000349282 | |
| ENST00000356825 | |
| ENSP00000262160 | |
| ENST00000262160 | |
| ENSRNOG00000018140 | |
| ENSRNOP00000048329 | |
| ENSRNOT00000046847 |
| Homologene ID | 21197 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 108051 |
|---|
| RGD ID | 3031 |
|---|
| MedScan ID | 4087 |
|---|---|
| 319898 |
| Primary Cell Localization | Nucleus |
|---|
| IPI ID | IPI00198544 |
|---|---|
| IPI00458087 | |
| IPI00556692 | |
| IPI00019548 | |
| IPI00220364 | |
| IPI00385246 | |
| IPI00646977 | |
| IPI00639978 | |
| IPI00643248 | |
| IPI00645481 | |
| IPI00391840 |
| KEGG pathway | Wnt signaling pathway |
|---|---|
| Cell cycle | |
| TGF-beta signaling pathway | |
| Adherens junction |