Protein SMURF1

URN	urn:agi-llid:57154
Total Entities	0
Connectivity	338
Name	SMURF1
Description	similar to Smad ubiquitination regulatory factor 1 isoform 2
Notes	This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.

GO Molecular Function	ligase activity
	ubiquitin-protein ligase activity
	activin binding
	I-SMAD binding
	R-SMAD binding

GO Biological Process	negative regulation of ossification
	regulation of axon extension
	cell differentiation
	negative regulation of transforming growth factor beta receptor signaling pathway
	negative regulation of BMP signaling pathway
	transforming growth factor beta receptor signaling pathway
	ubiquitin-dependent SMAD protein catabolic process
	BMP signaling pathway
	protein export from nucleus
	positive regulation of protein ubiquitination
	ectoderm development
	receptor catabolic process
	protein ubiquitination
	protein polyubiquitination
	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
	proteasome-mediated ubiquitin-dependent protein catabolic process
	protein localization to cell surface

Pathway	Tight Junction Assembly (JAMs)
	Basal Breast Cancer
	Ovarian Cancer Overview
	Impaired TGFB2 Signaling in Osteoarthritis
	ActivinR -> SMAD2/3 signaling
	TGFBR/BMPR -> SMAD2/3 signaling
	BMP7-ACVR2 Expression Targets
	INHBA-ACVR2/ACVR1 Expression Targets
	MSTN-ACVR2/ACVR1 Expression Targets
	TGFB2-TGFBR1 Expression Targets
	TGFB3-TGFBR1 Expression Targets
	TGFB1-TGFBR1 Expression Targets
	TGFB1-TGFBR1/AP-1 Expression Targets
	transforming growth factor-beta Smad dependent signaling pathway
	transforming growth factor-beta Smad dependent signaling pathway
	altered transforming growth factor-beta Smad dependent signaling pathway
	transforming growth factor-beta Smad dependent signaling pathway

Group	negative regulation of ossification
	regulation of axon extension
	cell differentiation
	negative regulation of transforming growth factor beta receptor signaling pathway
	negative regulation of BMP signaling pathway
	transforming growth factor beta receptor signaling pathway
	ubiquitin-dependent SMAD protein catabolic process
	BMP signaling pathway
	protein export from nucleus
	positive regulation of protein ubiquitination
	ectoderm development
	ligase activity
	ubiquitin-protein ligase activity
	receptor catabolic process
	protein ubiquitination
	protein polyubiquitination
	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
	proteasome-mediated ubiquitin-dependent protein catabolic process
	protein localization to cell surface
	activin binding
	I-SMAD binding
	R-SMAD binding
	membrane
	nucleoplasm
	plasma membrane
	cytoplasm
	cytosol
	nucleus
	axon
	neuronal cell body

Source	Curated

Cell Localization	Cytoplasm
	Cell membrane

Alias	E3 ubiquitin-protein ligase SMURF1
	hSMURF1
	E3 ubiquitin ligase SMURF1
	Smad-specific E3 ubiquitin ligase 1
	Smad ubiquitination regulatory factor 1
	SMAD-specific E3 ubiquitin-protein ligase 1
	mKIAA1625
	4930431E10Rik
	RGD1309707
	KIAA1625
	OTTMUSP00000023999
	OTTMUSP00000024000
	OTTMUSP00000024001
	SMAD specific E3 ubiquitin protein ligase 1
	Smad-specific E3 ubiquitin ligase I
	smad ubiquitination regulatory factor I
	SMURF1
	4930431E10
	E3 ubiquitin ligase SMURF I
	LOC442601
	LOC729290
	LOC730332
	SMURF I
	LOC690516
	hypothetical protein LOC690516
	RIKEN cDNA 4930431E10 gene
	SMURF Is
	SMURF1s
	similar to Smad ubiquitination regulatory factor 1 isoform 2

Mouse chromosome position	5
	5 G2

OMIM ID	605568

Rat chromosome position	12p11

Hugo ID	16807

Human chromosome position	7q22.1
	7q21.1-q31.1

Swiss-Prot ID	SMUF1_HUMAN
	SMUF1_MOUSE

EC Number	6.3.2.-

Homologene ID	10712

MGI ID	1923038

RGD ID	1594738
	1603623

MedScan ID	57154