Protein A2m

URN	urn:agi-llid:2
Total Entities	0
Connectivity	1096
Name	A2m
Description	alpha-2-macroglobulin
Notes	plays a role in acute phase response; activated form induces a decrease in N-methyl-D-aspartate (NMDA) mediated calcium signaling [RGD]

GO Molecular Function	peptidase inhibitor activity
	endopeptidase inhibitor activity
	serine-type endopeptidase inhibitor activity
	growth factor binding
	enzyme binding
	protease binding
	tumor necrosis factor binding
	interleukin-1 binding
	interleukin-8 binding

GO Cellular Component	extracellular region
	platelet alpha granule lumen
	cytosol
	extracellular space
	extracellular vesicular exosome

GO Biological Process	female pregnancy
	negative regulation of complement activation, lectin pathway
	blood coagulation, intrinsic pathway
	blood coagulation
	platelet activation
	stem cell differentiation
	small GTPase mediated signal transduction
	regulation of small GTPase mediated signal transduction
	platelet degranulation
	response to nutrient
	response to carbon dioxide
	response to glucocorticoid
	response to wounding
	inflammatory response
	acute-phase response
	negative regulation of peptidase activity
	negative regulation of endopeptidase activity

Pathway	Extracellular Matrix Turnover
	Mechanism of Amyloid beta Clearance
	Proteins Involved in Pathogenesis of Alzheimer's Disease
	Traffic and Degradation of Extracellular Amyloid beta in Alzheimer's Disease
	IL6 Expression Targets
	IL11 Expression Targets
	GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets
	PRL-GHR/STAT Expression Targets
	CSH1-GHR Expression Targets
	PRL-PRLR Expression Targets
	CSH1-PRLR Expression Targets
	IFNG-IFNR Expression Targets
	HGF/STAT Expression Targets
	Insulin/STAT Expression Targets
	FGF2/STAT Expression Targets
	TNF/NF-kB Expression Targets
	transforming growth factor-beta Smad dependent signaling pathway
	kallikrein-kinin cascade pathway
	transforming growth factor-beta Smad dependent signaling pathway
	altered transforming growth factor-beta Smad dependent signaling pathway
	transforming growth factor-beta Smad dependent signaling pathway
	kallikrein-kinin cascade pathway

Group	female pregnancy
	negative regulation of complement activation, lectin pathway
	blood coagulation, intrinsic pathway
	blood coagulation
	platelet activation
	stem cell differentiation
	small GTPase mediated signal transduction
	regulation of small GTPase mediated signal transduction
	platelet degranulation
	response to nutrient
	response to carbon dioxide
	response to glucocorticoid
	response to wounding
	inflammatory response
	acute-phase response
	peptidase inhibitor activity
	endopeptidase inhibitor activity
	serine-type endopeptidase inhibitor activity
	negative regulation of peptidase activity
	negative regulation of endopeptidase activity
	growth factor binding
	enzyme binding
	protease binding
	tumor necrosis factor binding
	interleukin-1 binding
	interleukin-8 binding
	extracellular region
	platelet alpha granule lumen
	cytosol
	extracellular space
	extracellular vesicular exosome
	Secreted proteins
	Biofluids assayable substances

Cell Localization	Secreted
	Extracellular

Alias	A2MD
	CPAMD5
	FWP007
	S863-7
	alpha-2-macroglobulin
	alpha-2-M
	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
	A2mp
	alpha-2-macroglobulin-P
	Mam
	A2m1
	A2maa
	A2MAC1
	A2m
	alpha-2-macroglobulin of pregnancy
	DKFZp779b086
	MGC114358
	RATA2MAC I
	RATA2MAC1
	S863 7
	S863(7)
	S8637
	A2M of pregnancy
	A2-macroglobulin of pregnancy
	a macroglobulin
	alpha 2 macroglobin
	alpha macroglobulin
	alpha-macroglobulins
	macroglobulin a2
	macroglobulin alpha
	macroglobulin alpha 2
	A2(MG)
	A(2)MG
	A2-m
	A2MAC I
	A(2)M
	a2-macroglobulin
	A2MG
	A-2MG
	A2-MG
	A2MG_HUMAN
	alpha(1)-inhibitor 3, variant I
	Mug I
	Mug1
	murinoglobulin 1
	murinoglobulin I
	Alpha-2-macroglobulin precursor
	murinoglobulin II
	murinoglobulin 2
	Mug2
	alpha 2M
	Alpha-2-macroglobulin precursor (Alpha-2-M)
	OVOSTATIN PRECURSOR (OVOMACROGLOBULIN)
	60 bp gap between fragment 2 and fragment III
	60 bp gap between fragment 2 and fragment 3
	AI893533
	A-2M
	alpha 2-macroglobulin

Mouse chromosome position	6 57.49 cM
	6 61.7 cM

Rat chromosome position	4q42

Hugo ID	7

Human chromosome position	12p13.31
	12p13.3-p12.3

PIR ID	A94033
	A26122

Homologene ID	37248

MGI ID	2449119

RGD ID	2004

MedScan ID	2