| URN | urn:agi-llid:57154 |
|---|---|
| Connectivity | 98 |
| Name | Smurf1 |
| Description | similar to Smad ubiquitination regulatory factor 1 isoform 2 |
| Notes | This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. A similar protein in Xenopus is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined. |
| Pathway | ActivinR -> SMAD2/3 signaling |
|---|---|
| TGFBR/BMPR -> SMAD2/3 signaling | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway |
| GO Molecular Function | ligase activity |
|---|---|
| I-SMAD binding | |
| R-SMAD binding | |
| activin binding | |
| acid-amino acid ligase activity | |
| ubiquitin-protein ligase activity |
| GO Cellular Component | intracellular |
|---|---|
| plasma membrane | |
| cytoplasm |
| GO Biological Process | regulation of signaling pathway |
|---|---|
| negative regulation of ossification | |
| cell differentiation | |
| ectoderm development | |
| negative regulation of BMP signaling pathway | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of protein ubiquitination | |
| receptor catabolic process | |
| protein modification process | |
| protein ubiquitination | |
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| protein polyubiquitination | |
| modification-dependent protein catabolic process | |
| ubiquitin-dependent SMAD protein catabolic process | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| protein localization at cell surface | |
| protein export from nucleus | |
| BMP signaling pathway |
| Group | regulation of signaling pathway |
|---|---|
| negative regulation of ossification | |
| cell differentiation | |
| ectoderm development | |
| negative regulation of BMP signaling pathway | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of protein ubiquitination | |
| receptor catabolic process | |
| protein modification process | |
| protein ubiquitination | |
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| protein polyubiquitination | |
| modification-dependent protein catabolic process | |
| ubiquitin-dependent SMAD protein catabolic process | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| protein localization at cell surface | |
| protein export from nucleus | |
| BMP signaling pathway | |
| ligase activity | |
| I-SMAD binding | |
| R-SMAD binding | |
| activin binding | |
| acid-amino acid ligase activity | |
| ubiquitin-protein ligase activity | |
| intracellular | |
| plasma membrane | |
| cytoplasm |
| MedScan ID | 57154 |
|---|
| Hugo ID | 16807 |
|---|
| Human chromosome position | 7q22.1 |
|---|---|
| 7q21.1-q31.1 |
| LocusLink ID | 57154 |
|---|---|
| 75788 | |
| 690516 |
| Alias | KIAA1625 |
|---|---|
| E3 ubiquitin-protein ligase SMURF1 | |
| hSMURF1 | |
| E3 ubiquitin ligase SMURF1 | |
| Smad-specific E3 ubiquitin ligase 1 | |
| Smad ubiquitination regulatory factor 1 | |
| SMAD-specific E3 ubiquitin-protein ligase 1 | |
| mKIAA1625 | |
| 4930431E10Rik | |
| OTTMUSP00000023999 | |
| OTTMUSP00000024000 | |
| OTTMUSP00000024001 | |
| Smurf1 | |
| hypothetical protein LOC690516 | |
| SMAD specific E3 ubiquitin protein ligase 1 | |
| 4930431E10 | |
| E3 ubiquitin ligase SMURF I | |
| LOC442601 | |
| LOC729290 | |
| LOC730332 | |
| RGD1309707 | |
| smad ubiquitination regulatory factor I | |
| Smad-specific E3 ubiquitin ligase I | |
| SMURF I | |
| RIKEN cDNA 4930431E10 gene | |
| SMURF1s | |
| LOC690516 | |
| SMURF Is | |
| similar to Smad ubiquitination regulatory factor 1 isoform 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605568 |
|---|
| Mouse chromosome position | 5 |
|---|---|
| 5 G2 |
| GO ID | 0070411 |
|---|---|
| 0070412 | |
| 0016881 | |
| 0048185 | |
| 0016874 | |
| 0004842 | |
| 0030509 | |
| 0030154 | |
| 0007398 | |
| 0030514 | |
| 0030279 | |
| 0030512 | |
| 0031398 | |
| 0043161 | |
| 0006611 | |
| 0034394 | |
| 0006464 | |
| 0000209 | |
| 0016567 | |
| 0042787 | |
| 0032801 | |
| 0035466 | |
| 0030579 | |
| 0005737 | |
| 0005622 | |
| 0005886 | |
| 0019941 | |
| 0046332 | |
| 0005515 | |
| 0006512 |
| Rat chromosome position | 12p11 |
|---|
| Swiss-Prot Accession | Q547Q3 |
|---|---|
| Q9HCE7 | |
| Q8NDD8 | |
| Q8BSC0 | |
| Q9CUN6 | |
| Q80TB1 | |
| A4D279 | |
| O75853 | |
| Q9UJT8 | |
| Q3U412 | |
| Q8K300 | |
| Q6ZTM5 |
| Unigene ID | Hs.189329 |
|---|---|
| Mm.27735 | |
| Rn.13503 |
| KEGG ID | hsa:57154 |
|---|---|
| mmu:75788 | |
| rno:690516 |
| EC Number | 6.3.2.- |
|---|
| Swiss-Prot ID | SMUF1_HUMAN |
|---|---|
| SMUF1_MOUSE | |
| Q547Q3_HUMAN | |
| Q8BSC0_MOUSE | |
| A4D279_HUMAN |
| IPI ID | IPI00217054 |
|---|---|
| IPI00219332 | |
| IPI00331652 | |
| IPI00872848 | |
| IPI00872961 | |
| IPI00676774 | |
| IPI00720020 | |
| IPI00400609 | |
| IPI00566489 |
| Homologene ID | 10712 |
|---|
| RGD ID | 1309707 |
|---|---|
| 1594738 | |
| 1603623 |
| MGI ID | 1923038 |
|---|
| Source | Curated |
|---|