Protein A2m

URN	urn:agi-llid:2
Connectivity	491
Name	A2m
Description	alpha-2-macroglobulin
Notes	plays a role in acute phase response; activated form induces a decrease in N-methyl-D-aspartate (NMDA) mediated calcium signaling [RGD]

Pathway	transforming growth factor-beta Smad dependent signaling pathway
	altered transforming growth factor-beta Smad dependent signaling pathway

GO Molecular Function	growth factor binding
	receptor binding
	enzyme binding
	interleukin-1 binding
	tumor necrosis factor binding
	interleukin-8 binding
	peptidase inhibitor activity
	endopeptidase inhibitor activity
	serine-type endopeptidase inhibitor activity

GO Cellular Component	extracellular region
	extracellular space
	platelet alpha granule lumen

GO Biological Process	female pregnancy
	response to chemical stimulus
	negative regulation of complement activation, lectin pathway
	response to nutrient
	response to wounding
	response to carbon dioxide
	response to glucocorticoid stimulus
	inflammatory response
	acute-phase response

Group	extracellular region
	female pregnancy
	response to chemical stimulus
	negative regulation of complement activation, lectin pathway
	response to nutrient
	response to wounding
	response to carbon dioxide
	response to glucocorticoid stimulus
	inflammatory response
	acute-phase response
	growth factor binding
	receptor binding
	enzyme binding
	interleukin-1 binding
	tumor necrosis factor binding
	interleukin-8 binding
	peptidase inhibitor activity
	endopeptidase inhibitor activity
	serine-type endopeptidase inhibitor activity
	extracellular space
	platelet alpha granule lumen

MedScan ID	2

Hugo ID	7

Human chromosome position	12p13.3-p12.3

Alias	CPAMD5
	FWP007
	S863-7
	DKFZp779B086
	alpha-2-macroglobulin
	alpha-2-M
	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
	A2mp
	alpha-2-macroglobulin-P
	Mam
	A2m1
	A2maa
	A2MAC1
	MGC114358
	RATA2MAC1
	A2m
	A(2)M
	A(2)MG
	A2(MG)
	A2-m
	A2MAC I
	a2-macroglobulin
	A2MG
	A-2MG
	A2-MG
	A2MG_HUMAN
	alpha(1)-inhibitor 3, variant I
	Mug I
	Mug1
	murinoglobulin 1
	murinoglobulin I
	RATA2MAC I
	S863 7
	S863(7)
	S8637
	Alpha-2-macroglobulin precursor
	murinoglobulin II
	murinoglobulin 2
	Mug2
	alpha 2M
	Alpha-2-macroglobulin precursor (Alpha-2-M)
	OVOSTATIN PRECURSOR (OVOMACROGLOBULIN)
	60 bp gap between fragment 2 and fragment III
	60 bp gap between fragment 2 and fragment 3
	AI893533
	A-2M
	alpha 2-macroglobulin

OMIM ID	103950
	104300

Mouse chromosome position	6 61.7 cM

Rat chromosome position	4q42

PIR ID	A94033
	A26122

Cell Localization	Secreted
	Extracellular

Homologene ID	37248

RGD ID	2004

MGI ID	2449119