| URN | urn:agi-llid:2280 |
|---|---|
| Connectivity | 144 |
| Name | Fkbp1a |
| Description | FK506 binding protein 1a |
| Notes | mediates islet microsome Ca2+ release through binding to ryanodine receptor (RyR) and catalyzes the cis-trans isomerization of peptidyl-prolyl amide peptide bonds [RGD] |
| Pathway | transforming growth factor-beta Smad dependent signaling pathway |
|---|---|
| altered transforming growth factor-beta Smad dependent signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| drug binding | |
| isomerase activity | |
| SMAD binding | |
| macrolide binding | |
| activin binding | |
| transforming growth factor beta receptor binding | |
| type I transforming growth factor beta receptor binding | |
| FK506 binding | |
| transforming growth factor beta receptor activity | |
| peptidyl-prolyl cis-trans isomerase activity | |
| ryanodine-sensitive calcium-release channel activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| terminal cisterna | |
| sarcoplasmic reticulum membrane | |
| membrane fraction | |
| microsome | |
| axon terminus |
| GO Biological Process | heart trabecula formation |
|---|---|
| heart morphogenesis | |
| ventricular cardiac muscle tissue morphogenesis | |
| muscle contraction | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of protein ubiquitination | |
| negative regulation of protein phosphatase type 2B activity | |
| regulation of ryanodine-sensitive calcium-release channel activity | |
| release of sequestered calcium ion into cytosol | |
| T cell activation | |
| T cell proliferation | |
| protein folding | |
| beta-amyloid formation | |
| protein refolding | |
| 'de novo' protein folding | |
| protein maturation by protein folding | |
| SMAD protein complex assembly | |
| fibril organization | |
| regulation of immune response | |
| cytokine-mediated signaling pathway | |
| response to iron ion | |
| response to caffeine | |
| regulation of activin receptor signaling pathway | |
| positive regulation of protein binding |
| Ariadne Ontology | ER Ca++ release |
|---|
| Group | ER Ca++ release |
|---|---|
| heart trabecula formation | |
| heart morphogenesis | |
| ventricular cardiac muscle tissue morphogenesis | |
| muscle contraction | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of protein ubiquitination | |
| negative regulation of protein phosphatase type 2B activity | |
| regulation of ryanodine-sensitive calcium-release channel activity | |
| release of sequestered calcium ion into cytosol | |
| T cell activation | |
| T cell proliferation | |
| protein folding | |
| beta-amyloid formation | |
| protein refolding | |
| 'de novo' protein folding | |
| protein maturation by protein folding | |
| SMAD protein complex assembly | |
| fibril organization | |
| regulation of immune response | |
| cytokine-mediated signaling pathway | |
| response to iron ion | |
| response to caffeine | |
| regulation of activin receptor signaling pathway | |
| positive regulation of protein binding | |
| signal transducer activity | |
| drug binding | |
| isomerase activity | |
| SMAD binding | |
| macrolide binding | |
| activin binding | |
| transforming growth factor beta receptor binding | |
| type I transforming growth factor beta receptor binding | |
| FK506 binding | |
| transforming growth factor beta receptor activity | |
| peptidyl-prolyl cis-trans isomerase activity | |
| ryanodine-sensitive calcium-release channel activity | |
| cytoplasm | |
| cytosol | |
| terminal cisterna | |
| sarcoplasmic reticulum membrane | |
| membrane fraction | |
| microsome | |
| axon terminus |
| MedScan ID | 2280 |
|---|
| Hugo ID | 3711 |
|---|
| Human chromosome position | 20p13 |
|---|
| LocusLink ID | 2280 |
|---|---|
| 14225 | |
| 25639 |
| Alias | FKBP1 |
|---|---|
| PKC12 | |
| PKCI2 | |
| FKBP12 | |
| PPIASE | |
| FKBP-12 | |
| FKBP12C | |
| RP11-314N13.2 | |
| peptidyl-prolyl cis-trans isomerase FKBP1A | |
| FKBP-1A | |
| rotamase | |
| 12 kDa FKBP | |
| FKBP12-Exip3 | |
| PPIase FKBP1A | |
| OTTHUMP00000029980 | |
| immunophilin FKBP12 | |
| FK506 binding protein12 | |
| FK506-binding protein 1 | |
| FK506-binding protein 12 | |
| 12 kDa FK506-binding protein | |
| protein kinase C inhibitor 2 | |
| FK506-binding protein 1A (12kD) | |
| FK506-binding protein, T-cell, 12-kD | |
| Fkbp | |
| 12kDa | |
| mFKBP1 | |
| mFKBP12 | |
| FKBP12-T1 | |
| FKBP12-T2 | |
| RP23-419G21.5 | |
| OTTMUSP00000016917 | |
| FK506-binding protein 1A | |
| FK506 Binding Protein12-T1 | |
| FK506 binding protein12-T2 | |
| Fkbp2 | |
| MGC156543 | |
| FK506-binding protein 1 (12kD) | |
| FK506 binding protein 2 (13 kDa) | |
| 12 kDa FK506 binding protein 1A | |
| 12kDa FK506 binding protein | |
| Chain A, Fk506 Binding Protein Mutant, Homodimeric Complex | |
| FK506 binding protein 12 | |
| FK506 binding protein 1A | |
| FK506 binding protein 1A (12kD) | |
| FK506 binding protein 1A, 12kDa | |
| FK506-binding protein I | |
| FKB I | |
| FKB1 | |
| FKB1_HUMAN | |
| FKBP I | |
| Fkbp1a | |
| mFKBP I | |
| OTTHUMP00000029978 | |
| peptidyl-prolyl cis-trans isomerase | |
| peptidylprolyl isomerase FKBP1 | |
| protein kinase C inhibitor II | |
| rotamases | |
| peptidylprolyl isomerase FKBP1 | |
| mFKBP1s | |
| FKBP12s | |
| FK506 binding protein 1a (12 kDa) | |
| mFKBP Is | |
| FK506 binding protein 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 186945 |
|---|
| Mouse chromosome position | 2 |
|---|---|
| 2 G3 |
| GO ID | 0005528 |
|---|---|
| 0046332 | |
| 0048185 | |
| 0016853 | |
| 0005527 | |
| 0003755 | |
| 0005219 | |
| 0004871 | |
| 0005024 | |
| 0005160 | |
| 0034713 | |
| 0006458 | |
| 0007183 | |
| 0042110 | |
| 0034205 | |
| 0043206 | |
| 0003007 | |
| 0060347 | |
| 0032513 | |
| 0043123 | |
| 0032092 | |
| 0031398 | |
| 0006457 | |
| 0022417 | |
| 0042026 | |
| 0032925 | |
| 0050776 | |
| 0060314 | |
| 0055010 | |
| 0005737 | |
| 0005829 | |
| 0014802 | |
| 0008144 | |
| 0042098 | |
| 0019221 | |
| 0006936 | |
| 0001933 | |
| 0051209 | |
| 0031000 | |
| 0043679 | |
| 0005624 | |
| 0005792 | |
| 0033017 | |
| 0010039 | |
| 0005515 | |
| 0004872 | |
| 0005524 | |
| 0006810 | |
| 0016020 |
| Rat chromosome position | 3q41 |
|---|
| Swiss-Prot Accession | P62942 |
|---|---|
| Q0VDC6 | |
| Q0VDC5 | |
| Q1JUQ3 | |
| Q1JUQ4 | |
| Q1JUQ5 | |
| Q3V793 | |
| Q5W0X3 | |
| Q9UH88 | |
| A2AT05 | |
| P26883 | |
| Q1JUQ6 | |
| Q1JUQ7 | |
| Q1JUQ8 | |
| Q3UBA0 | |
| Q3UKJ3 | |
| Q3ULN5 | |
| Q62658 | |
| P20071 | |
| Q4VC47 | |
| Q6FGD9 | |
| Q6LEU3 | |
| Q9H103 | |
| Q9H566 | |
| A0JN04 | |
| P97533 | |
| Q545E9 | |
| D3DVW6 |
| PIR ID | I65284 |
|---|---|
| JH0528 |
| Unigene ID | Hs.471933 |
|---|---|
| Hs.700839 | |
| Mm.278458 | |
| Mm.381214 | |
| Rn.80611 |
| KEGG ID | hsa:2280 |
|---|---|
| mmu:14225 | |
| rno:25639 |
| EC Number | 5.2.1.8 |
|---|
| Swiss-Prot ID | FKB1A_HUMAN |
|---|---|
| FKB1A_RAT | |
| FKB1A_MOUSE | |
| Q0VDC6_HUMAN | |
| A2AT05_MOUSE | |
| D3DVW6_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Endoplasmic reticulum | |
| Mitochondria |
| IPI ID | IPI00873810 |
|---|---|
| IPI00231434 | |
| IPI00266899 | |
| IPI00413778 | |
| IPI00847442 | |
| IPI00647507 | |
| IPI00760016 | |
| IPI00760030 | |
| IPI00759922 | |
| IPI00653179 |
| Homologene ID | 105139 |
|---|
| RGD ID | 2617 |
|---|
| MGI ID | 95541 |
|---|