| URN | urn:agi-llid:4092 |
|---|---|
| Connectivity | 420 |
| Name | Smad7 |
| Description | MAD homolog 7 (Drosophila) |
| Notes | negative regulator of TGF-beta and activin [RGD] |
| Pathway | ActivinR -> SMAD2/3 signaling |
|---|---|
| TGFBR/BMPR -> SMAD2/3 signaling | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway |
| GO Molecular Function | transcription factor activity |
|---|---|
| beta-catenin binding | |
| collagen binding | |
| I-SMAD binding | |
| activin binding | |
| ubiquitin protein ligase binding | |
| type I transforming growth factor beta receptor binding | |
| promoter binding | |
| transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity |
| GO Cellular Component | intracellular |
|---|---|
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| transcription factor complex | |
| nucleus | |
| catenin complex | |
| cell-cell adherens junction |
| GO Biological Process | positive regulation of anti-apoptosis |
|---|---|
| ureteric bud development | |
| negative regulation of epithelial to mesenchymal transition | |
| artery morphogenesis | |
| ventricular septum morphogenesis | |
| ventricular cardiac muscle tissue morphogenesis | |
| regulation of cardiac muscle contraction | |
| regulation of ventricular cardiomyocyte membrane depolarization | |
| cellular protein complex localization | |
| negative regulation of BMP signaling pathway | |
| negative regulation of pathway-restricted SMAD protein phosphorylation | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of transcription | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| negative regulation of transcription | |
| negative regulation of transcription by competitive promoter binding | |
| negative regulation of gene-specific transcription from RNA polymerase II promoter | |
| negative regulation of peptidyl-threonine phosphorylation | |
| negative regulation of peptidyl-serine phosphorylation | |
| negative regulation of protein ubiquitination | |
| negative regulation of ubiquitin-protein ligase activity | |
| positive regulation of protein ubiquitination | |
| regulation of transcription, DNA-dependent | |
| negative regulation of transcription factor activity | |
| positive regulation of cell-cell adhesion | |
| negative regulation of cell migration | |
| transcription | |
| pathway-restricted SMAD protein phosphorylation | |
| adherens junction assembly | |
| response to laminar fluid shear stress | |
| regulation of activin receptor signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| protein stabilization | |
| intracellular signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| BMP signaling pathway |
| Ariadne Ontology | SMAD |
|---|---|
| iSMAD |
| Group | SMAD |
|---|---|
| iSMAD | |
| positive regulation of anti-apoptosis | |
| ureteric bud development | |
| negative regulation of epithelial to mesenchymal transition | |
| artery morphogenesis | |
| ventricular septum morphogenesis | |
| ventricular cardiac muscle tissue morphogenesis | |
| regulation of cardiac muscle contraction | |
| regulation of ventricular cardiomyocyte membrane depolarization | |
| cellular protein complex localization | |
| negative regulation of BMP signaling pathway | |
| negative regulation of pathway-restricted SMAD protein phosphorylation | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of transcription | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| negative regulation of transcription | |
| negative regulation of transcription by competitive promoter binding | |
| negative regulation of gene-specific transcription from RNA polymerase II promoter | |
| negative regulation of peptidyl-threonine phosphorylation | |
| negative regulation of peptidyl-serine phosphorylation | |
| negative regulation of protein ubiquitination | |
| negative regulation of ubiquitin-protein ligase activity | |
| positive regulation of protein ubiquitination | |
| regulation of transcription, DNA-dependent | |
| negative regulation of transcription factor activity | |
| positive regulation of cell-cell adhesion | |
| negative regulation of cell migration | |
| transcription | |
| pathway-restricted SMAD protein phosphorylation | |
| adherens junction assembly | |
| response to laminar fluid shear stress | |
| regulation of activin receptor signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| protein stabilization | |
| intracellular signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| BMP signaling pathway | |
| transcription factor activity | |
| beta-catenin binding | |
| collagen binding | |
| I-SMAD binding | |
| activin binding | |
| ubiquitin protein ligase binding | |
| type I transforming growth factor beta receptor binding | |
| promoter binding | |
| transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| transcription factor complex | |
| nucleus | |
| catenin complex | |
| cell-cell adherens junction |
| MedScan ID | 4092 |
|---|
| Hugo ID | 6773 |
|---|
| Human chromosome position | 18q21.1 |
|---|
| LocusLink ID | 4092 |
|---|---|
| 17131 | |
| 81516 |
| Alias | CRCS3 |
|---|---|
| MADH7 | |
| MADH8 | |
| FLJ16482 | |
| mothers against decapentaplegic homolog 7 | |
| hSMAD7 | |
| MAD homolog 8 | |
| mothers against DPP homolog 8 | |
| SMAD, mothers against DPP homolog 7 | |
| Mothers against decapentaplegic, drosophila, homolog of, 7 | |
| MAD (mothers against decapentaplegic, Drosophila) homolog 7 | |
| SMAD 7 | |
| OTTMUSP00000028959 | |
| SMAD family member 7 | |
| mothers against DPP homolog 7 | |
| mothers against decapentaplegic homolog 8 | |
| MAD homolog 7 | |
| homolog of Drosophila Mothers against decapentaplegic 7 | |
| homolog of Drosophila Mothers against decapentaplegic VII | |
| MAD (mothers against decapentaplegic homolog 7 | |
| MAD (mothers against decapentaplegic homolog VII | |
| MAD (mothers against decapentaplegic, Drosophila) homolog VII | |
| MAD homolog 7 (Drosophila) | |
| MAD homolog VII | |
| MAD, mothers against decapentaplegic homolog 7 (Drosophila) | |
| Mothers against decapentaplegic homolog VII | |
| Mothers against decapentaplegic, drosophila, homolog of, VII | |
| Mothers against DPP homolog VII | |
| SMAD, mothers against DPP homolog VII | |
| SMAD7 | |
| MAD, mothers against decapentaplegic homolog 7 | |
| Mothers against DPP homolog 7 | |
| Mothers against DPP homolog VII | |
| hSMAD7s | |
| MAD (mothers against decapentaplegic Drosophila) homolog 7 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602932 |
|---|---|
| 612229 | |
| 114500 |
| Mouse chromosome position | 18 |
|---|
| GO ID | 0070411 |
|---|---|
| 0048185 | |
| 0008013 | |
| 0005518 | |
| 0010843 | |
| 0030617 | |
| 0034713 | |
| 0031625 | |
| 0030509 | |
| 0034333 | |
| 0048844 | |
| 0034629 | |
| 0030514 | |
| 0030336 | |
| 0010719 | |
| 0010553 | |
| 0060394 | |
| 0033137 | |
| 0010801 | |
| 0031397 | |
| 0016481 | |
| 0010944 | |
| 0043433 | |
| 0030512 | |
| 0051444 | |
| 0060389 | |
| 0045768 | |
| 0022409 | |
| 0032436 | |
| 0031398 | |
| 0050821 | |
| 0032925 | |
| 0055117 | |
| 0006355 | |
| 0017015 | |
| 0060373 | |
| 0034616 | |
| 0001657 | |
| 0055010 | |
| 0060412 | |
| 0016342 | |
| 0005913 | |
| 0005737 | |
| 0005829 | |
| 0005622 | |
| 0005634 | |
| 0005886 | |
| 0005667 | |
| 0003700 | |
| 0023034 | |
| 0045449 | |
| 0006350 | |
| 0007179 | |
| 0007242 | |
| 0046332 | |
| 0043130 | |
| 0005515 | |
| 0005575 | |
| 0005076 | |
| 0006950 | |
| 0007182 | |
| 0008372 |
| Rat chromosome position | 18q12.3 |
|---|
| Swiss-Prot Accession | O15105 |
|---|---|
| B2RPW6 | |
| O35253 | |
| O88406 | |
| O88709 | |
| O14740 | |
| Q6DK23 | |
| Q9QUG1 |
| Unigene ID | Hs.465087 |
|---|---|
| Mm.34407 | |
| Rn.29980 |
| KEGG ID | hsa:4092 |
|---|---|
| mmu:17131 | |
| rno:81516 |
| Swiss-Prot ID | SMAD7_MOUSE |
|---|---|
| SMAD7_HUMAN | |
| SMAD7_RAT | |
| B2RPW6_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00128690 |
|---|---|
| IPI00228622 | |
| IPI00005079 | |
| IPI00327140 | |
| IPI00642840 |
| Homologene ID | 4314 |
|---|
| RGD ID | 69314 |
|---|
| MGI ID | 1100518 |
|---|
| Source | Curated |
|---|
| KEGG pathway | TGF-beta signaling pathway |
|---|