| URN | urn:agi-llid:7040 |
|---|---|
| Total Entities | 0 |
| Connectivity | 9838 |
| Name | TGFB1 |
| Description | transforming growth factor, beta 1 |
| Notes | binds the TGFbeta receptor; plays a role in regulation of cell growth and proliferation; induces synthesis of extracellular matrix proteins and may play a role in fibrosis [RGD] |
| GO Molecular Function | protein N-terminus binding |
|---|---|
| enzyme binding | |
| growth factor activity | |
| transforming growth factor beta receptor binding | |
| type II transforming growth factor beta receptor binding | |
| protein homodimerization activity | |
| protein heterodimerization activity |
| GO Cellular Component | extracellular matrix |
|---|---|
| extracellular region | |
| Golgi lumen | |
| platelet alpha granule lumen | |
| cell surface | |
| cytoplasm | |
| secretory granule | |
| nucleus | |
| microvillus | |
| axon | |
| neuronal cell body | |
| proteinaceous extracellular matrix | |
| extracellular space |
| GO Biological Process | growth |
|---|---|
| germ cell migration | |
| mammary gland branching involved in thelarche | |
| female pregnancy | |
| T cell homeostasis | |
| positive regulation of isotype switching to IgA isotypes | |
| tolerance induction to self antigen | |
| lymph node development | |
| hematopoietic progenitor cell differentiation | |
| T cell differentiation | |
| regulatory T cell differentiation | |
| myeloid dendritic cell differentiation | |
| negative regulation of macrophage cytokine production | |
| negative regulation of immune response | |
| defense response to fungus, incompatible interaction | |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | |
| active induction of host immune response by virus | |
| T cell activation | |
| negative regulation of T cell activation | |
| negative regulation of T cell proliferation | |
| cell proliferation | |
| negative regulation of hyaluronan biosynthetic process | |
| ATP biosynthetic process | |
| positive regulation of collagen biosynthetic process | |
| MAPK cascade | |
| positive regulation of MAP kinase activity | |
| positive regulation of histone deacetylation | |
| positive regulation of histone acetylation | |
| hyaluronan catabolic process | |
| positive regulation of phosphatidylinositol 3-kinase activity | |
| morphogenesis of a branching structure | |
| ossification involved in bone remodeling | |
| negative regulation of ossification | |
| positive regulation of bone mineralization | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| positive regulation vascular endothelial growth factor production | |
| positive regulation of interleukin-17 production | |
| branch elongation involved in mammary gland duct branching | |
| regulation of branching involved in mammary gland duct morphogenesis | |
| connective tissue replacement involved in inflammatory response wound healing | |
| blood coagulation | |
| platelet activation | |
| myelination | |
| embryo development | |
| skeletal system development | |
| frontal suture morphogenesis | |
| regulation of cartilage development | |
| chondrocyte differentiation | |
| ureteric bud development | |
| lung development | |
| organ morphogenesis | |
| organ regeneration | |
| lens fiber cell differentiation | |
| inner ear development | |
| positive regulation of odontogenesis | |
| epithelial to mesenchymal transition | |
| positive regulation of epithelial to mesenchymal transition | |
| mammary gland development | |
| salivary gland morphogenesis | |
| skeletal muscle tissue development | |
| negative regulation of skeletal muscle tissue development | |
| negative regulation of myoblast differentiation | |
| regulation of striated muscle tissue development | |
| negative regulation of neuroblast proliferation | |
| digestive tract development | |
| positive regulation of blood vessel endothelial cell migration | |
| negative regulation of blood vessel endothelial cell migration | |
| aging | |
| face morphogenesis | |
| negative regulation of fat cell differentiation | |
| positive regulation of smooth muscle cell differentiation | |
| macrophage derived foam cell differentiation | |
| cell death | |
| cell activation | |
| cell growth | |
| positive regulation of exit from mitosis | |
| regulation of actin cytoskeleton reorganization | |
| cell cycle arrest | |
| mitotic cell cycle checkpoint | |
| positive regulation of cell cycle arrest | |
| negative regulation of cell cycle | |
| negative regulation of mitotic cell cycle | |
| positive regulation of cell division | |
| protein kinase B signaling | |
| positive regulation of protein kinase B signaling | |
| extrinsic apoptotic signaling pathway | |
| positive regulation of SMAD protein import into nucleus | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| lipopolysaccharide-mediated signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| common-partner SMAD protein phosphorylation | |
| SMAD protein complex assembly | |
| SMAD protein import into nucleus | |
| pathway-restricted SMAD protein phosphorylation | |
| epidermal growth factor receptor signaling pathway | |
| regulation of cell growth | |
| negative regulation of cell growth | |
| positive regulation of protein secretion | |
| platelet degranulation | |
| negative regulation of cell-cell adhesion | |
| cellular calcium ion homeostasis | |
| negative regulation of release of sequestered calcium ion into cytosol | |
| positive regulation of cell migration | |
| regulation of cell migration | |
| positive regulation of fibroblast migration | |
| positive regulation of apoptotic process | |
| extracellular matrix organization | |
| extracellular matrix assembly | |
| cell-cell junction organization | |
| positive regulation of cell proliferation | |
| negative regulation of cell proliferation | |
| regulation of cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| negative regulation of epithelial cell proliferation | |
| mononuclear cell proliferation | |
| protein import into nucleus, translocation | |
| protein export from nucleus | |
| regulation of protein import into nucleus | |
| positive regulation of protein import into nucleus | |
| negative regulation of phagocytosis | |
| regulation of sodium ion transport | |
| response to drug | |
| response to organic substance | |
| response to glucose | |
| response to estradiol | |
| response to vitamin D | |
| response to cholesterol | |
| cellular response to dexamethasone stimulus | |
| response to progesterone | |
| cellular response to growth factor stimulus | |
| cellular response to organic cyclic compound | |
| response to organic cyclic compound | |
| positive regulation of chemotaxis | |
| response to hypoxia | |
| defense response | |
| response to wounding | |
| inflammatory response | |
| wound healing | |
| response to laminar fluid shear stress | |
| evasion or tolerance of host defenses by virus | |
| response to radiation | |
| positive regulation of protein localization to nucleus | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein dephosphorylation | |
| positive regulation of superoxide anion generation | |
| positive regulation of gene expression | |
| positive regulation of protein complex assembly | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of DNA replication | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of protein phosphorylation | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of NAD+ ADP-ribosyltransferase activity | |
| endoderm development | |
| receptor catabolic process | |
| protein phosphorylation | |
| phosphate-containing compound metabolic process | |
| modulation by virus of host morphology or physiology | |
| viral life cycle | |
| regulation of binding | |
| positive regulation of transcription regulatory region DNA binding | |
| regulation of DNA binding |
| Pathway | Cell Cycle |
|---|---|
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| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Proteins Involved in Pathogenesis of Multiple Myeloma | |
| Proteins Involved in Pathogenesis of T-cell Acute Lymphoblastic Leukemia | |
| Chronic Myeloid Leukemia Overview | |
| Dendritic Cell Function in Crohn's Disease | |
| Th17 Cell Activation in Crohn's Disease | |
| Immune Response Activation in Hashimoto's Thyroiditis | |
| Hodgkin Lymphoma Overview | |
| Effects of Hodgkin and Reed-Sternberg Cells on Microenvironment Cells | |
| Proteins Involved in Pathogenesis of Hodgkin Lymphoma | |
| Diffuse Large-B-cell Lymphoma Overview | |
| Proteins Involved in Pathogenesis of Diffuse Large-B-cell Lymphoma | |
| Proteins Involved in Pathogenesis of Follicular Lymphoma | |
| Dendritic Cells in Psoriasis | |
| Differentiation of Psoriatic T-cells | |
| Proteins Involved in Pathogenesis of Psoriasis | |
| Basal Breast Cancer | |
| Crohn's Disease Overview | |
| Proliferative Diabetic Retinopathy | |
| Role of Hexosamine Pathway in Diabetic Microangiopathy | |
| Role of Protein Kinase C in Diabetic Microangiopathy | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 1 | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 | |
| Peripheral Tissue Microangiopathy in Insulin Resistance | |
| Proteins Involved in Pathogenesis of Inflammatory Bowel Diseases | |
| Graves Ophthalmopathy | |
| Hashimoto's Thyroiditis Overview | |
| Proteins Involved in Pathogenesis of Hashimoto's Thyroiditis | |
| Ovarian Cancer Overview | |
| Melanoma Overview | |
| Proteins Involved in Pathogenesis of Systemic Lupus Erythematosus | |
| Proteins Involved in Pathogenesis of Prostate Cancer | |
| Activation of Immunoglobulin Class-Switch Recombination | |
| TLR4 Signaling in Leukocytes | |
| Th17 Cell Differentiation | |
| Regulatory T-cell Differentiation | |
| Cancer Overview | |
| Proteins Involved in Pathogenesis of Cystic Fibrosis | |
| Proteins Involved in Pathogenesis of Atherosclerosis | |
| Proteins Involved in Pathogenesis of Hypertrophic Cardiomyopathy | |
| Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy | |
| Hypertrophic Cardiomyopathy Overview | |
| Impairment of BMP and TGF-beta Signaling in Familial and Idiopathic Pulmonary Arterial Hypertension | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| Proteins Involved in Pathogenesis of Hypoxia-Induced Pulmonary Hypertension | |
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Activation of Glioma Stem Cell Program | |
| Proteins Involved in Pathogenesis of Glioma | |
| Proteins Involved in Pathogenesis of Ependymoma | |
| Medulloblastoma Overview | |
| Proteins Involved in Pathogenesis of Medulloblastoma | |
| Proteins Involved in Pathogenesis of HIV Type 1 Infection | |
| Reduction of Th17 cell Numbers in HIV Type 1 Infection | |
| Block of CD4+ T-cell Signaling in HIV Type 1 Infection | |
| Proteins Involved in Pathogenesis of Osteoarthritis | |
| Steroid-Induced Cataract | |
| Proteins Involved in Pathogenesis of Cataract | |
| TGFBR Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Pancreatic Neuroendocrine Tumors | |
| Growth Factor Signaling in Hepatocellular Carcinoma | |
| Proteins Involved in Pathogenesis of Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| Vascularization in Hepatocellular Carcinoma | |
| Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis | |
| Synovial Fibroblast Proliferation in Rheumatoid Arthritis | |
| Proteins Involved in Pathogenesis of Rheumatoid Arthritis | |
| Proteins Involved in Pathogenesis of Systemic Scleroderma | |
| Model Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma Fibroblasts 1 | |
| Mechanism of Skin Fibrosis in Systemic Scleroderma | |
| Role of Th2 cells in Systemic Scleroderma | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| Myocardial Remodeling in Myocardial Ischemia | |
| Myocardial Infarction | |
| TGFBR -> ATF/GADD/MAX/TP53 signaling | |
| TGFBR -> CREB/ELK-SRF signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| TGFBR -> SMAD1/5/9 signaling | |
| TGFBR -> AP-1 signaling | |
| TGFBR/BMPR -> SMAD2/3 signaling | |
| Cyclosporine-Induced Nephrotoxicity | |
| Ethanol-Induced Hepatotoxicity | |
| MDK/PTN Expression Targets | |
| TGFB3-TGFBR2 Expression Targets | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| BMP7-ACVR2 Expression Targets | |
| INHBA-ACVR2/ACVR1 Expression Targets | |
| MSTN-ACVR2/ACVR1 Expression Targets | |
| BMP2-BMPR2 Expression Targets | |
| BMP4-BMPR2 Expression Targets | |
| BMP7-BMPR2/ACVR2 Expression Targets | |
| NODAL-ACVR2B Expression Targets | |
| TLR4/NF-kB/IRF Expression Targets | |
| TLR7 Expression Targets | |
| NTF3 Expression Targets | |
| TNF/STAT Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| ICAM1 Expression Targets | |
| Fibrinogen Expression Targets | |
| CD19 Expression Targets | |
| IL13 Expression Targets | |
| IL5 Expression Targets | |
| IL9 Expression Targets | |
| IL3 Expression Targets | |
| Thrombopoietin/STAT Expression Targets | |
| CSF3 Expression Targets | |
| CNTF Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| CCL3 Expression Targets | |
| CCL11 Expression Targets | |
| NPY Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| S100B Expression Targets | |
| TGFA/CTNNB/CTNND Expression Targets | |
| TGFA/STAT Expression Targets | |
| TGFA/HIF1A Expression Targets | |
| Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets | |
| TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF9/AP-1/CREB/MYC Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| Adenosine Expression Targets | |
| Prostaglandin F Expression Targets | |
| Glutamate/Gq Expression Targets | |
| AVP/Gq -> STAT Expression Targets | |
| AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| GNRH1 Expression Targets | |
| TAC1 Expression Targets | |
| VIP Expression Targets | |
| GCG Expression Targets | |
| AVP/Gs -> STAT Expression Targets | |
| AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets | |
| POMC Expression Targets | |
| CD86/STAT Expression Targets | |
| CD86/NF-kB Expression Targets | |
| CD86/AP-1 Expression Targets | |
| TCR/STAT Expression Targets | |
| TCR/AP-1 Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| TCR/NF-kB Expression Targets | |
| FGF2/STAT Expression Targets | |
| IL1A Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| INHBA-ACVR2/BMPR Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| TNF/NF-kB Expression Targets | |
| PAF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| CSF2/STAT Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| LPA Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/STAT Expression Targets | |
| TGFA/AP-1/ATF Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| IL1B Expression Targets | |
| FGF9/STAT Expression Targets | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| metformin-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| colorectal cancer pathway | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway | |
| transforming growth factor-beta Smad dependent signaling pathway |
| Group | TGF family |
|---|---|
| growth | |
| germ cell migration | |
| mammary gland branching involved in thelarche | |
| female pregnancy | |
| T cell homeostasis | |
| positive regulation of isotype switching to IgA isotypes | |
| tolerance induction to self antigen | |
| lymph node development | |
| hematopoietic progenitor cell differentiation | |
| T cell differentiation | |
| regulatory T cell differentiation | |
| myeloid dendritic cell differentiation | |
| negative regulation of macrophage cytokine production | |
| negative regulation of immune response | |
| defense response to fungus, incompatible interaction | |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | |
| active induction of host immune response by virus | |
| T cell activation | |
| negative regulation of T cell activation | |
| negative regulation of T cell proliferation | |
| cell proliferation | |
| negative regulation of hyaluronan biosynthetic process | |
| ATP biosynthetic process | |
| positive regulation of collagen biosynthetic process | |
| MAPK cascade | |
| positive regulation of MAP kinase activity | |
| positive regulation of histone deacetylation | |
| positive regulation of histone acetylation | |
| hyaluronan catabolic process | |
| positive regulation of phosphatidylinositol 3-kinase activity | |
| morphogenesis of a branching structure | |
| ossification involved in bone remodeling | |
| negative regulation of ossification | |
| positive regulation of bone mineralization | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| positive regulation vascular endothelial growth factor production | |
| positive regulation of interleukin-17 production | |
| branch elongation involved in mammary gland duct branching | |
| regulation of branching involved in mammary gland duct morphogenesis | |
| connective tissue replacement involved in inflammatory response wound healing | |
| blood coagulation | |
| platelet activation | |
| myelination | |
| embryo development | |
| skeletal system development | |
| frontal suture morphogenesis | |
| regulation of cartilage development | |
| chondrocyte differentiation | |
| ureteric bud development | |
| lung development | |
| organ morphogenesis | |
| organ regeneration | |
| lens fiber cell differentiation | |
| inner ear development | |
| positive regulation of odontogenesis | |
| epithelial to mesenchymal transition | |
| positive regulation of epithelial to mesenchymal transition | |
| mammary gland development | |
| salivary gland morphogenesis | |
| skeletal muscle tissue development | |
| negative regulation of skeletal muscle tissue development | |
| negative regulation of myoblast differentiation | |
| regulation of striated muscle tissue development | |
| negative regulation of neuroblast proliferation | |
| digestive tract development | |
| positive regulation of blood vessel endothelial cell migration | |
| negative regulation of blood vessel endothelial cell migration | |
| aging | |
| face morphogenesis | |
| negative regulation of fat cell differentiation | |
| positive regulation of smooth muscle cell differentiation | |
| macrophage derived foam cell differentiation | |
| cell death | |
| cell activation | |
| cell growth | |
| positive regulation of exit from mitosis | |
| regulation of actin cytoskeleton reorganization | |
| cell cycle arrest | |
| mitotic cell cycle checkpoint | |
| positive regulation of cell cycle arrest | |
| negative regulation of cell cycle | |
| negative regulation of mitotic cell cycle | |
| positive regulation of cell division | |
| protein kinase B signaling | |
| positive regulation of protein kinase B signaling | |
| extrinsic apoptotic signaling pathway | |
| positive regulation of SMAD protein import into nucleus | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| lipopolysaccharide-mediated signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| common-partner SMAD protein phosphorylation | |
| SMAD protein complex assembly | |
| SMAD protein import into nucleus | |
| pathway-restricted SMAD protein phosphorylation | |
| epidermal growth factor receptor signaling pathway | |
| regulation of cell growth | |
| negative regulation of cell growth | |
| positive regulation of protein secretion | |
| platelet degranulation | |
| negative regulation of cell-cell adhesion | |
| cellular calcium ion homeostasis | |
| negative regulation of release of sequestered calcium ion into cytosol | |
| positive regulation of cell migration | |
| regulation of cell migration | |
| positive regulation of fibroblast migration | |
| positive regulation of apoptotic process | |
| extracellular matrix organization | |
| extracellular matrix assembly | |
| cell-cell junction organization | |
| positive regulation of cell proliferation | |
| negative regulation of cell proliferation | |
| regulation of cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| negative regulation of epithelial cell proliferation | |
| mononuclear cell proliferation | |
| protein import into nucleus, translocation | |
| protein export from nucleus | |
| regulation of protein import into nucleus | |
| positive regulation of protein import into nucleus | |
| negative regulation of phagocytosis | |
| regulation of sodium ion transport | |
| response to drug | |
| response to organic substance | |
| response to glucose | |
| response to estradiol | |
| response to vitamin D | |
| response to cholesterol | |
| cellular response to dexamethasone stimulus | |
| response to progesterone | |
| cellular response to growth factor stimulus | |
| cellular response to organic cyclic compound | |
| response to organic cyclic compound | |
| positive regulation of chemotaxis | |
| response to hypoxia | |
| defense response | |
| response to wounding | |
| inflammatory response | |
| wound healing | |
| response to laminar fluid shear stress | |
| evasion or tolerance of host defenses by virus | |
| response to radiation | |
| positive regulation of protein localization to nucleus | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein dephosphorylation | |
| positive regulation of superoxide anion generation | |
| positive regulation of gene expression | |
| positive regulation of protein complex assembly | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of DNA replication | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of protein phosphorylation | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of NAD+ ADP-ribosyltransferase activity | |
| endoderm development | |
| receptor catabolic process | |
| protein phosphorylation | |
| phosphate-containing compound metabolic process | |
| modulation by virus of host morphology or physiology | |
| viral life cycle | |
| regulation of binding | |
| positive regulation of transcription regulatory region DNA binding | |
| regulation of DNA binding | |
| protein N-terminus binding | |
| enzyme binding | |
| growth factor activity | |
| transforming growth factor beta receptor binding | |
| type II transforming growth factor beta receptor binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| extracellular matrix | |
| extracellular region | |
| Golgi lumen | |
| platelet alpha granule lumen | |
| cell surface | |
| cytoplasm | |
| secretory granule | |
| nucleus | |
| microvillus | |
| axon | |
| neuronal cell body | |
| proteinaceous extracellular matrix | |
| extracellular space | |
| Genes Associated with Systemic Lupus Erythematosus | |
| Genes with Mutations Associated with Systemic Scleroderma | |
| Genes with Mutations Associated with Atherosclerosis | |
| Genes with Mutations Associated with Cystic Fibrosis | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| LocusLink ID | 7040 |
|---|---|
| 21803 | |
| 59086 | |
| 43846 |
| Cell Localization | Extracellular |
|---|---|
| Secreted | |
| Extracellular space | |
| Extracellular matrix |
| GO ID | 0019899 |
|---|---|
| 0008083 | |
| 0047485 | |
| 0046982 | |
| 0042803 | |
| 0005114 | |
| 0006754 | |
| 0000165 | |
| 0007183 | |
| 0007184 | |
| 0043029 | |
| 0046732 | |
| 0002460 | |
| 0007568 | |
| 0007596 | |
| 0060751 | |
| 0007050 | |
| 0016049 | |
| 0045216 | |
| 0006874 | |
| 0071549 | |
| 0071407 | |
| 0002062 | |
| 0007182 | |
| 0002248 | |
| 0009817 | |
| 0048565 | |
| 0009790 | |
| 0007492 | |
| 0007173 | |
| 0001837 | |
| 0019049 | |
| 0085029 | |
| 0030198 | |
| 0097191 | |
| 0060325 | |
| 0007565 | |
| 0060364 | |
| 0008354 | |
| 0002244 | |
| 0030214 | |
| 0006954 | |
| 0048839 | |
| 0070306 | |
| 0031663 | |
| 0048535 | |
| 0010742 | |
| 0060744 | |
| 0007093 | |
| 0019048 | |
| 0032943 | |
| 0042552 | |
| 0043011 | |
| 0008156 | |
| 0042130 | |
| 0043537 | |
| 0045786 | |
| 0030308 | |
| 0008285 | |
| 0022408 | |
| 0050680 | |
| 0045599 | |
| 1900126 | |
| 0050777 | |
| 0010936 | |
| 0045930 | |
| 0045662 | |
| 0007406 | |
| 0030279 | |
| 0050765 | |
| 0001933 | |
| 0051280 | |
| 0048642 | |
| 0000122 | |
| 0045892 | |
| 0030512 | |
| 0031100 | |
| 0043932 | |
| 0060389 | |
| 0006796 | |
| 0030168 | |
| 0002576 | |
| 0043406 | |
| 1901666 | |
| 0051092 | |
| 0060391 | |
| 0043065 | |
| 0043536 | |
| 0030501 | |
| 0090190 | |
| 0071158 | |
| 0051781 | |
| 0030335 | |
| 0008284 | |
| 0032270 | |
| 0050921 | |
| 0032967 | |
| 0050679 | |
| 0010718 | |
| 0031536 | |
| 0010763 | |
| 0010628 | |
| 0035066 | |
| 0031065 | |
| 0032740 | |
| 0048298 | |
| 0042482 | |
| 0010862 | |
| 0033138 | |
| 0010800 | |
| 0043552 | |
| 0031334 | |
| 0035307 | |
| 0042307 | |
| 0051897 | |
| 0001934 | |
| 0050714 | |
| 0051152 | |
| 0032930 | |
| 0045944 | |
| 2000679 | |
| 0045893 | |
| 0010575 | |
| 0006611 | |
| 0000060 | |
| 0043491 | |
| 0006468 | |
| 0032801 | |
| 0051101 | |
| 0051098 | |
| 0060762 | |
| 0061035 | |
| 0030334 | |
| 0042306 | |
| 0002028 | |
| 0016202 | |
| 0017015 | |
| 0045066 | |
| 0070723 | |
| 0042493 | |
| 0032355 | |
| 0009749 | |
| 0001666 | |
| 0034616 | |
| 0032570 | |
| 0009314 | |
| 0033280 | |
| 0009611 | |
| 0007435 | |
| 0002513 | |
| 0007179 | |
| 0001657 | |
| 0019058 | |
| 0005796 | |
| 0030424 | |
| 0009986 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0005902 | |
| 0043025 | |
| 0005634 | |
| 0031093 | |
| 0005578 | |
| 0005160 | |
| 0042110 | |
| 0030217 | |
| 0001775 | |
| 0008219 | |
| 0008283 | |
| 0071363 | |
| 0006952 | |
| 0040007 | |
| 0030879 | |
| 0001763 | |
| 0050868 | |
| 0009887 | |
| 1900182 | |
| 2000249 | |
| 0042127 | |
| 0010033 | |
| 0007519 | |
| 0001501 | |
| 0042060 | |
| 0031012 | |
| 0030141 | |
| 0030324 | |
| 0001558 | |
| 0014070 | |
| 0043499 | |
| 0006917 | |
| 0031575 | |
| 0016563 | |
| 0016481 | |
| 0043193 | |
| 0010552 | |
| 0045941 | |
| 0051789 | |
| 0042476 | |
| 0045595 | |
| 0005515 | |
| 0006916 | |
| 0000074 | |
| 0007267 |
| Alias | CED |
|---|---|
| LAP | |
| DPD1 | |
| TGFB | |
| TGFbeta | |
| transforming growth factor beta-1 | |
| TGF-beta-1 | |
| latency-associated peptide | |
| Tgfb-1 | |
| TGFbeta1 | |
| TGF-beta1 | |
| TGF-beta 1 | |
| regulatory protein | |
| transforming growth factor-beta 1 | |
| transforming growth factor, beta-1 | |
| Camurati-Engelmann disease protein | |
| Camurati-Engelmann disease gene | |
| Transforming growth factor beta 1 | |
| TGF-beta I | |
| TGFB1 | |
| TGF beta | |
| TGF1_RAT | |
| TGF eta | |
| beta 1 transforming growth factor | |
| transforming growth factor (TGF)-beta | |
| transforming growth factor beta | |
| Tgfb I | |
| TGF1_HUMAN | |
| TGF-beta 1 protein | |
| diaphyseal dysplasia 1, progressive | |
| DPD I | |
| transforming growth factor, beta | |
| transforming growth factor, beta 1 | |
| Transforming growth factor beta 1 precursor | |
| transforming growth factor, beta 1 (Camurati-Engelmann disease) | |
| diaphyseal dysplasia 1, progressive (Camurati-Engelmann disease) | |
| Camurati-Engelmann disease |
| Mouse chromosome position | 7 13.98 cM |
|---|---|
| 7 6.5 cM |
| OMIM ID | 190180 |
|---|---|
| 219700 | |
| 131300 |
| Rat chromosome position | 1q22 |
|---|
| Hugo ID | 11766 |
|---|
| Human chromosome position | 19q13.1 |
|---|---|
| 19q13.2 |
| Swiss-Prot Accession | P01137 |
|---|---|
| P04202 | |
| Q3UNK5 | |
| P17246 | |
| Q53YM8 | |
| A8K792 | |
| Q9UCG4 | |
| Q49IK8 | |
| Q49IL8 | |
| Q5PY19 | |
| Q671U8 | |
| Q671V1 | |
| Q7Z487 | |
| Q7Z488 | |
| Q86YU2 | |
| Q9R231 |
| PIR ID | S10219 |
|---|---|
| A27513 | |
| A01396 |
| Unigene ID | Hs.645227 |
|---|---|
| Mm.248380 | |
| Rn.40136 | |
| Hs.155218 | |
| Hs.1103 |
| KEGG ID | hsa:7040 |
|---|---|
| mmu:21803 | |
| rno:59086 |
| Swiss-Prot ID | TGFB1_RAT |
|---|---|
| TGFB1_HUMAN | |
| TGFB1_MOUSE | |
| Q3UNK5_MOUSE |
| Ensembl ID | ENSMUSG00000002603 |
|---|---|
| ENSMUSP00000002678 | |
| ENSMUST00000002678 | |
| ENSRNOG00000020652 | |
| ENSRNOP00000028051 | |
| ENSRNOT00000028051 |
| Homologene ID | 540 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98725 |
|---|
| RGD ID | 69051 |
|---|
| MedScan ID | 7040 |
|---|
| Primary Cell Localization | Extracellular |
|---|
| IPI ID | IPI00000075 |
|---|---|
| IPI00114457 | |
| IPI00214538 |
| KEGG pathway | Cell cycle |
|---|---|
| MAPK signaling pathway | |
| TGF-beta signaling pathway |