| URN | urn:agi-Regulation:inout-urn:agi-llid:4092:out-urn:agi-llid:7046::negative |
|---|---|
| References | 3 |
| Connectivity | 2 |
| Effect | negative |
| TextRef | info:pmid/14718519#abs:8 |
|---|---|
| MedLine Reference | 14718519:7 |
| Sentence | The dephosphorylation of TbetaRI mediated by Smad7 is an effective mechanism for governing negative feedback in TGFbeta signaling. |
| TextRef | info:pmid/10915727#abs:3 |
|---|---|
| MedLine Reference | 10915727:2 |
| Sentence | Antagonistic Smad 7 forms stable association with the activated TGF-beta type I receptor, blocking phosphorylation of receptor-regulated Smads. |
| TextRef | info:pmid/10498890#abs:3 |
|---|---|
| MedLine Reference | 10498890:2 |
| Sentence | Phosphorylation of Smad2/Smad3 by activated TbetaRI is inhibited by two newly discovered members of the Smad family, Smad6 and Smad7. |
| Organism | Mus musculus |