Protein Msh6

URN	urn:agi-llid:2956
Total Entities	0
Connectivity	229
Name	Msh6
Description	mutS homolog 6 (E. coli)
Notes	This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Ariadne Ontology	DNA repair

GO Molecular Function	chromatin binding
	MutLalpha complex binding
	protein homodimerization activity
	nucleotide binding
	ADP binding
	ATP binding
	DNA binding
	damaged DNA binding
	double-stranded DNA binding
	four-way junction DNA binding
	mismatched DNA binding
	guanine-thymine mispair binding
	single base insertion or deletion binding
	single guanine insertion binding
	single thymine insertion binding
	oxidized purine DNA binding
	magnesium ion binding
	ATPase activity
	DNA-dependent ATPase activity

GO Biological Process	reciprocal meiotic recombination
	meiotic mismatch repair
	intrinsic apoptotic signaling pathway
	intrinsic apoptotic signaling pathway in response to DNA damage response
	negative regulation of DNA recombination
	isotype switching
	ATP catabolic process
	DNA repair
	maintenance of DNA repeat elements
	mismatch repair
	somatic recombination of immunoglobulin gene segments
	response to DNA damage stimulus
	somatic hypermutation of immunoglobulin genes
	response to UV
	positive regulation of helicase activity
	determination of adult lifespan

Pathway	Single-Strand Mismatch DNA Repair
	colorectal cancer pathway
	colorectal cancer pathway

Group	DNA repair
	reciprocal meiotic recombination
	meiotic mismatch repair
	intrinsic apoptotic signaling pathway
	intrinsic apoptotic signaling pathway in response to DNA damage response
	negative regulation of DNA recombination
	isotype switching
	ATP catabolic process
	DNA repair
	maintenance of DNA repeat elements
	mismatch repair
	somatic recombination of immunoglobulin gene segments
	response to DNA damage stimulus
	somatic hypermutation of immunoglobulin genes
	response to UV
	positive regulation of helicase activity
	determination of adult lifespan
	chromatin binding
	MutLalpha complex binding
	protein homodimerization activity
	nucleotide binding
	ADP binding
	ATP binding
	DNA binding
	damaged DNA binding
	double-stranded DNA binding
	four-way junction DNA binding
	mismatched DNA binding
	guanine-thymine mispair binding
	single base insertion or deletion binding
	single guanine insertion binding
	single thymine insertion binding
	oxidized purine DNA binding
	magnesium ion binding
	ATPase activity
	DNA-dependent ATPase activity
	nuclear chromosome
	MutSalpha complex
	nuclear chromatin

MedScan ID	2956
	649635

Hugo ID	7329

Human chromosome position	2p16

Alias	GTBP
	HSAP
	HNPCC5
	DNA mismatch repair protein Msh6
	p160
	GTMBP
	hMSH6
	sperm-associated protein
	mutS-alpha 160 kDa subunit
	G/T mismatch-binding protein
	AU044881
	AW550279
	mutS homolog 6 (E. coli)
	rCG61559-like
	Msh6
	mutS homolog 6
	mutS (E. coli) homolog 6
	human sperm-associated protein
	human sperm associated protein
	mutS homolog VI
	G/T mismatch binding protein
	mutS (E. coli) homolog VI
	LOC100360342
	mutS homolog
	G/T mismatch binding protein
	HNPCC5s

Unigene ID	Hs.445052
	Mm.18210

PIR ID	JC5839

Cell Localization	Nucleus

Mouse chromosome position	17 47.0 cM

Rat chromosome position	6

Homologene ID	149

MGI ID	1343961

RGD ID	2322311

Primary Cell Localization	Nucleus