| URN | urn:agi-llid:4436 |
|---|---|
| Total Entities | 0 |
| Connectivity | 442 |
| Name | Msh2 |
| Description | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) |
| Notes | MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. |
| Ariadne Ontology | DNA repair |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | protein C-terminus binding |
|---|---|
| enzyme binding | |
| MutLalpha complex binding | |
| protein kinase binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ADP binding | |
| ATP binding | |
| DNA binding | |
| damaged DNA binding | |
| centromeric DNA binding | |
| double-stranded DNA binding | |
| single-stranded DNA binding | |
| Y-form DNA binding | |
| loop DNA binding | |
| double-strand-single-strand DNA junction binding | |
| four-way junction DNA binding | |
| mismatched DNA binding | |
| guanine-thymine mispair binding | |
| dinucleotide insertion or deletion binding | |
| single base insertion or deletion binding | |
| single guanine insertion binding | |
| single thymine insertion binding | |
| dinucleotide repeat insertion binding | |
| oxidized purine DNA binding | |
| magnesium ion binding | |
| ATPase activity | |
| DNA-dependent ATPase activity |
| GO Cellular Component | nuclear chromosome |
|---|---|
| MutSalpha complex | |
| MutSbeta complex | |
| nucleus |
| GO Biological Process | cell cycle |
|---|---|
| meiotic gene conversion | |
| cell cycle arrest | |
| meiotic mismatch repair | |
| intra-S DNA damage checkpoint | |
| negative regulation of reciprocal meiotic recombination | |
| germ cell development | |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| negative regulation of DNA recombination | |
| negative regulation of apoptotic process | |
| negative regulation of neuron apoptotic process | |
| B cell differentiation | |
| isotype switching | |
| ATP catabolic process | |
| DNA repair | |
| maintenance of DNA repeat elements | |
| double-strand break repair | |
| postreplication repair | |
| mismatch repair | |
| somatic recombination of immunoglobulin gene segments | |
| somatic recombination of immunoglobulin genes involved in immune response | |
| oxidative phosphorylation | |
| response to DNA damage stimulus | |
| apoptotic process | |
| B cell mediated immunity | |
| somatic hypermutation of immunoglobulin genes | |
| response to drug | |
| response to amino acid stimulus | |
| response to organic cyclic compound | |
| response to UV-B | |
| response to X-ray | |
| positive regulation of helicase activity | |
| male gonad development | |
| in utero embryonic development | |
| determination of adult lifespan | |
| spermatogenesis |
| Pathway | Single-Strand Mismatch DNA Repair |
|---|---|
| colorectal cancer pathway | |
| colorectal cancer pathway |
| Group | DNA repair |
|---|---|
| cell cycle | |
| meiotic gene conversion | |
| cell cycle arrest | |
| meiotic mismatch repair | |
| intra-S DNA damage checkpoint | |
| negative regulation of reciprocal meiotic recombination | |
| germ cell development | |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| negative regulation of DNA recombination | |
| negative regulation of apoptotic process | |
| negative regulation of neuron apoptotic process | |
| B cell differentiation | |
| isotype switching | |
| ATP catabolic process | |
| DNA repair | |
| maintenance of DNA repeat elements | |
| double-strand break repair | |
| postreplication repair | |
| mismatch repair | |
| somatic recombination of immunoglobulin gene segments | |
| somatic recombination of immunoglobulin genes involved in immune response | |
| oxidative phosphorylation | |
| response to DNA damage stimulus | |
| apoptotic process | |
| B cell mediated immunity | |
| somatic hypermutation of immunoglobulin genes | |
| response to drug | |
| response to amino acid stimulus | |
| response to organic cyclic compound | |
| response to UV-B | |
| response to X-ray | |
| positive regulation of helicase activity | |
| male gonad development | |
| in utero embryonic development | |
| determination of adult lifespan | |
| spermatogenesis | |
| protein C-terminus binding | |
| enzyme binding | |
| MutLalpha complex binding | |
| protein kinase binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| ADP binding | |
| ATP binding | |
| DNA binding | |
| damaged DNA binding | |
| centromeric DNA binding | |
| double-stranded DNA binding | |
| single-stranded DNA binding | |
| Y-form DNA binding | |
| loop DNA binding | |
| double-strand-single-strand DNA junction binding | |
| four-way junction DNA binding | |
| mismatched DNA binding | |
| guanine-thymine mispair binding | |
| dinucleotide insertion or deletion binding | |
| single base insertion or deletion binding | |
| single guanine insertion binding | |
| single thymine insertion binding | |
| dinucleotide repeat insertion binding | |
| oxidized purine DNA binding | |
| magnesium ion binding | |
| ATPase activity | |
| DNA-dependent ATPase activity | |
| nuclear chromosome | |
| MutSalpha complex | |
| MutSbeta complex | |
| nucleus | |
| Biofluids assayable substances |
| MedScan ID | 4436 |
|---|
| Hugo ID | 7325 |
|---|
| Human chromosome position | 2p21 |
|---|---|
| 2p22-p21 |
| LocusLink ID | 4436 |
|---|---|
| 17685 | |
| 81709 |
| Alias | FCC1 |
|---|---|
| COCA1 | |
| HNPCC | |
| LCFS2 | |
| HNPCC1 | |
| DNA mismatch repair protein Msh2 | |
| hMSH2 | |
| AI788990 | |
| mutS protein homolog 2 | |
| mismatch repair protein | |
| OTTHUMP00000200306 | |
| Msh2 | |
| Lynch cancer family syndrome II gene | |
| Lynch cancer family syndrome II protein | |
| mismatch repair protein 2 | |
| mismatch repair protein II | |
| mutS (E. coli) homolog 2 | |
| mutS (E. coli) homolog II | |
| mutS homolog 2 | |
| mutS homolog 2 (E. coli) | |
| mutS homolog 2, colon cancer, nonpolyposis type 1 | |
| mutS homolog II | |
| LCFS2 protein | |
| mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | |
| COCA I gene | |
| Lynch cancer family syndrome 2 protein | |
| Lynch cancer family syndrome 2 gene | |
| COCA1 gene | |
| colon cancer, nonpolyposis type 1 gene | |
| colon cancer, nonpolyposis type I gene | |
| FCC I gene | |
| FCC1 gene | |
| HNPCC I gene | |
| HNPCC1 gene | |
| LCFS2 gene | |
| COCA I | |
| colon cancer, nonpolyposis type 1 | |
| colon cancer, nonpolyposis type I | |
| FCC I | |
| HNPCC I | |
| HNPCC1s | |
| HNPCC Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609309 |
|---|---|
| 120435 | |
| 158320 | |
| 276300 | |
| 114030 | |
| 137800 | |
| 162200 | |
| 114400 |
| Unigene ID | Hs.597656 |
|---|---|
| Mm.4619 | |
| Rn.3174 | |
| Mm.471165 |
| KEGG ID | hsa:4436 |
|---|---|
| mmu:17685 | |
| rno:81709 |
| Swiss-Prot Accession | B4E2Z2 |
|---|---|
| P43246 | |
| P43247 | |
| Q3TZI5 | |
| P54275 | |
| O75488 | |
| Q0ZAI9 | |
| Q0ZAJ0 | |
| Q0ZAJ1 | |
| Q0ZAJ2 | |
| Q53FK0 | |
| Q53GS1 | |
| Q53RU4 | |
| Q6VBB7 | |
| Q80V79 |
| GO ID | 0043531 |
|---|---|
| 0005524 | |
| 0016887 | |
| 0003677 | |
| 0008094 | |
| 0032405 | |
| 0000403 | |
| 0019237 | |
| 0032139 | |
| 0032181 | |
| 0000406 | |
| 0003690 | |
| 0019899 | |
| 0000400 | |
| 0032137 | |
| 0000404 | |
| 0000287 | |
| 0030983 | |
| 0032357 | |
| 0008022 | |
| 0042803 | |
| 0019901 | |
| 0032142 | |
| 0032143 | |
| 0003697 | |
| 0030183 | |
| 0019724 | |
| 0006281 | |
| 0007050 | |
| 0008340 | |
| 0006302 | |
| 0007281 | |
| 0001701 | |
| 0031573 | |
| 0042771 | |
| 0045190 | |
| 0043570 | |
| 0008584 | |
| 0006311 | |
| 0000710 | |
| 0006298 | |
| 0045910 | |
| 0043524 | |
| 0045128 | |
| 0006119 | |
| 0051096 | |
| 0006301 | |
| 0010224 | |
| 0010165 | |
| 0043200 | |
| 0042493 | |
| 0014070 | |
| 0016446 | |
| 0016447 | |
| 0007283 | |
| 0032301 | |
| 0032302 | |
| 0000228 | |
| 0003684 | |
| 0000166 | |
| 0006200 | |
| 0006915 | |
| 0007049 | |
| 0043066 | |
| 0006974 | |
| 0002204 | |
| 0005634 | |
| 0032138 | |
| 0004422 | |
| 0006928 | |
| 0045786 | |
| 0006164 | |
| 0006284 |
| PIR ID | S53608 |
|---|---|
| I64819 | |
| JC6184 |
| Swiss-Prot ID | MSH2_MOUSE |
|---|---|
| MSH2_HUMAN | |
| MSH2_RAT | |
| Q3TZI5_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00118158 |
|---|---|
| IPI00017303 | |
| IPI00211849 | |
| IPI00783458 | |
| IPI00816513 | |
| IPI00783348 | |
| IPI00893933 | |
| IPI00892635 |
| Mouse chromosome position | 17 45.9 cM |
|---|
| Rat chromosome position | 6q12 |
|---|
| Homologene ID | 210 |
|---|
| MGI ID | 101816 |
|---|
| RGD ID | 620786 |
|---|
| Primary Cell Localization | Nucleus |
|---|