| URN | urn:agi-llid:4089 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1098 |
| Name | Smad4 |
| Description | MAD homolog 4 (Drosophila) |
| Notes | transduces signal from TGF-beta; deletion of human homolog gene is associated with pancreatic carcinomas [RGD] |
| Ariadne Ontology | SMAD |
|---|---|
| Tumor suppressors | |
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | protein binding transcription factor activity |
|---|---|
| chromatin binding | |
| SMAD binding | |
| collagen binding | |
| protein homodimerization activity | |
| I-SMAD binding | |
| R-SMAD binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| core promoter proximal region sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| sequence-specific DNA binding transcription factor activity | |
| transforming growth factor beta receptor, common-partner cytoplasmic mediator activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| transcription factor complex | |
| activin responsive factor complex | |
| centrosome | |
| protein complex | |
| SMAD protein complex | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | cell proliferation |
|---|---|
| positive regulation of SMAD protein import into nucleus | |
| positive regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| positive regulation of BMP signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of cell proliferation | |
| SMAD protein signal transduction | |
| BMP signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of cell death | |
| negative regulation of cell proliferation | |
| positive regulation of epithelial to mesenchymal transition | |
| neural crest cell differentiation | |
| neuron fate commitment | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| SMAD protein complex assembly | |
| response to transforming growth factor beta stimulus | |
| response to hypoxia | |
| negative regulation of protein catabolic process | |
| regulation of transforming growth factor beta2 production | |
| regulation of hair follicle development | |
| developmental growth | |
| somite rostral-caudal axis specification | |
| formation of anatomical boundary | |
| branching involved in ureteric bud morphogenesis | |
| metanephric mesenchyme morphogenesis | |
| nephrogenic mesenchyme morphogenesis | |
| palate development | |
| kidney development | |
| sebaceous gland development | |
| mesoderm development | |
| endoderm development | |
| in utero embryonic development | |
| anterior-posterior pattern specification | |
| tissue morphogenesis | |
| gastrulation | |
| gastrulation with mouth forming second | |
| gene expression | |
| regulation of binding |
| Pathway | Cell Cycle |
|---|---|
| TGFBR -> MEF/MYOD/MYOG signaling | |
| ActivinR -> SMAD2/3 signaling | |
| TGFBR -> SMAD1/5/9 signaling | |
| ActivinR/BMPR -> SMAD1/5/9 signaling | |
| TGFBR/BMPR -> SMAD2/3 signaling | |
| Dexamethasone-Induced Osteoporosis | |
| Ethanol-Induced Hepatotoxicity | |
| BMP7-ACVR2 Expression Targets | |
| INHBA-ACVR2/ACVR1 Expression Targets | |
| MSTN-ACVR2/ACVR1 Expression Targets | |
| INHBB-ACVR2 Expression Target | |
| BMP2-BMPR2 Expression Targets | |
| BMP4-BMPR2 Expression Targets | |
| BMP15-BMPR2 Expression Targets | |
| BMP7-BMPR2/ACVR2 Expression Targets | |
| GDF5-BMPR2/ACVR2 Expression Targets | |
| BMP6-ACVR2A Expression Targets | |
| MSTN-ACVR2/BMPR Expression Targets | |
| TDGF1-ACVR2B Expression Targets | |
| NODAL-ACVR2B Expression Targets | |
| AMH-AMHR2 Expression Targets | |
| TGFB2-TGFBR1 Expression Targets | |
| TGFB3-TGFBR1 Expression Targets | |
| INHBA-ACVR2/BMPR Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| pancreatic cancer pathway | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| colorectal cancer pathway |
| Group | SMAD |
|---|---|
| Tumor suppressors | |
| cell proliferation | |
| positive regulation of SMAD protein import into nucleus | |
| positive regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| positive regulation of BMP signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of cell proliferation | |
| SMAD protein signal transduction | |
| BMP signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of cell death | |
| negative regulation of cell proliferation | |
| positive regulation of epithelial to mesenchymal transition | |
| neural crest cell differentiation | |
| neuron fate commitment | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| SMAD protein complex assembly | |
| response to transforming growth factor beta stimulus | |
| response to hypoxia | |
| negative regulation of protein catabolic process | |
| regulation of transforming growth factor beta2 production | |
| regulation of hair follicle development | |
| developmental growth | |
| somite rostral-caudal axis specification | |
| formation of anatomical boundary | |
| branching involved in ureteric bud morphogenesis | |
| metanephric mesenchyme morphogenesis | |
| nephrogenic mesenchyme morphogenesis | |
| palate development | |
| kidney development | |
| sebaceous gland development | |
| mesoderm development | |
| endoderm development | |
| in utero embryonic development | |
| anterior-posterior pattern specification | |
| tissue morphogenesis | |
| gastrulation | |
| gastrulation with mouth forming second | |
| gene expression | |
| regulation of binding | |
| protein binding transcription factor activity | |
| chromatin binding | |
| SMAD binding | |
| collagen binding | |
| protein homodimerization activity | |
| I-SMAD binding | |
| R-SMAD binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| core promoter proximal region sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| sequence-specific DNA binding transcription factor activity | |
| transforming growth factor beta receptor, common-partner cytoplasmic mediator activity | |
| nucleoplasm | |
| nucleolus | |
| transcription factor complex | |
| activin responsive factor complex | |
| centrosome | |
| protein complex | |
| SMAD protein complex | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| MedScan ID | 4089 |
|---|
| Hugo ID | 6770 |
|---|
| Human chromosome position | 18q21.1 |
|---|
| LocusLink ID | 4089 |
|---|---|
| 17128 | |
| 50554 | |
| 28063 |
| Alias | JIP |
|---|---|
| DPC4 | |
| MADH4 | |
| MYHRS | |
| mothers against decapentaplegic homolog 4 | |
| MAD homolog 4 | |
| SMAD, mothers against DPP homolog 4 | |
| deleted in pancreatic carcinoma locus 4 | |
| deletion target in pancreatic carcinoma 4 | |
| mothers against decapentaplegic, Drosophila, homolog of, 4 | |
| AW743858 | |
| D18Wsu70e | |
| Smad 4 | |
| mothers against DPP homolog 4 | |
| deletion target in pancreatic carcinoma 4 homolog | |
| MAD (mothers against decapentaplegic Drosophila) homolog 4 | |
| Mothers against decapentaplegic, Drosophila, homolog of, IV | |
| MAD homolog IV | |
| MAD, mothers against decapentaplegic homolog 4 (Drosophila) | |
| Mothers against decapentaplegic homolog IV | |
| MAD homolog 4 (Drosophila) | |
| Mothers against DPP homolog IV | |
| OTTHUMP00000163548 | |
| OTTMUSP00000023201 | |
| OTTMUSP00000023202 | |
| SMAD, mothers against DPP homolog IV | |
| Deletion target in pancreatic carcinoma IV | |
| DNA segment, Chr 18, Wayne State University 70, expressed | |
| MAD (mothers against decapentaplegic homolog IV | |
| homolog of Drosophila Mothers against decapentaplegic,, 4 | |
| homolog of Drosophila Mothers against decapentaplegic,, IV | |
| hSMAD4 | |
| MAD (mothers against decapentaplegic homolog 4 | |
| MAD (mothers against decapentaplegic, Drosophila) homolog IV | |
| MAD, mothers against decapentaplegic homolog 4 | |
| SMAD family member 4 | |
| Mothers against DPP homolog 4 | |
| SMAD4 | |
| MAD (mothers against decapentaplegic, Drosophila) homolog 4 | |
| Mothers against DPP homolog IV | |
| hSMAD4s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600993 |
|---|---|
| 174900 | |
| 175050 | |
| 603391 | |
| 187300 |
| Unigene ID | Hs.75862 |
|---|---|
| Mm.100399 | |
| Rn.9774 |
| KEGG ID | hsa:4089 |
|---|---|
| mmu:17128 | |
| rno:50554 |
| Swiss-Prot Accession | Q13485 |
|---|---|
| P97471 | |
| O70437 | |
| A8K405 | |
| Q6GTP6 | |
| Q9CW56 | |
| Q9BYG6 | |
| Q811W8 |
| GO ID | 0003677 |
|---|---|
| 0070411 | |
| 0070412 | |
| 0003682 | |
| 0005518 | |
| 0000987 | |
| 0000988 | |
| 0042803 | |
| 0043565 | |
| 0003700 | |
| 0044212 | |
| 0030616 | |
| 0030509 | |
| 0007183 | |
| 0060395 | |
| 0001658 | |
| 0008283 | |
| 0048589 | |
| 0007492 | |
| 0048859 | |
| 0001702 | |
| 0010467 | |
| 0001701 | |
| 0007498 | |
| 0072133 | |
| 0060548 | |
| 0030308 | |
| 0008285 | |
| 0042177 | |
| 0000122 | |
| 0045892 | |
| 0072134 | |
| 0014033 | |
| 0048663 | |
| 0060021 | |
| 0030513 | |
| 0060391 | |
| 0010718 | |
| 0010862 | |
| 0045944 | |
| 0045893 | |
| 0030511 | |
| 0051098 | |
| 0051797 | |
| 0017015 | |
| 0032909 | |
| 0001666 | |
| 0071559 | |
| 0048733 | |
| 0032525 | |
| 0006367 | |
| 0006351 | |
| 0007179 | |
| 0071141 | |
| 0032444 | |
| 0005813 | |
| 0005737 | |
| 0005829 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0005667 | |
| 0046332 | |
| 0009952 | |
| 0007369 | |
| 0001822 | |
| 0042127 | |
| 0006357 | |
| 0006355 | |
| 0048729 | |
| 0005622 | |
| 0043234 | |
| 0010843 | |
| 0016563 | |
| 0045941 | |
| 0001657 | |
| 0045449 | |
| 0006350 | |
| 0005515 | |
| 0007184 | |
| 0007182 | |
| 0009887 | |
| 0003712 | |
| 0010003 |
| PIR ID | S71811 |
|---|
| Swiss-Prot ID | SMAD4_HUMAN |
|---|---|
| SMAD4_RAT | |
| SMAD4_MOUSE | |
| Q6GTP6_MOUSE | |
| A8K405_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00013404 |
|---|---|
| IPI00198545 | |
| IPI00125567 | |
| IPI00646338 | |
| IPI00644112 | |
| IPI00644586 | |
| IPI00556778 |
| Mouse chromosome position | 18 48.0 cM |
|---|
| Rat chromosome position | 18q12.3 |
|---|
| Homologene ID | 31310 |
|---|
| MGI ID | 894293 |
|---|---|
| 106263 |
| RGD ID | 3033 |
|---|
| Primary Cell Localization | Nucleus |
|---|
| KEGG pathway | Wnt signaling pathway |
|---|---|
| Cell cycle | |
| TGF-beta signaling pathway | |
| Adherens junction |