Protein Tgfb1

URN urn:agi-llid:7040
Total Entities 0
Connectivity 7122
Name Tgfb1
Description transforming growth factor, beta 1
Notes binds the TGFbeta receptor; plays a role in regulation of cell growth and proliferation; induces synthesis of extracellular matrix proteins and may play a role in fibrosis [RGD]

Ariadne Ontology TGF family
Secreted proteins
Biofluids assayable substances

GO Molecular Function protein N-terminus binding
enzyme binding
growth factor activity
transforming growth factor beta receptor binding
type II transforming growth factor beta receptor binding
protein homodimerization activity
protein heterodimerization activity
eukaryotic cell surface binding

GO Cellular Component extracellular matrix
extracellular region
Golgi lumen
platelet alpha granule lumen
cell surface
cytoplasm
secretory granule
nucleus
microvillus
axon
neuronal cell body
extracellular space
proteinaceous extracellular matrix

GO Biological Process cell proliferation
growth
defense response to fungus, incompatible interaction
active induction of host immune response by virus
evasion or tolerance of host defenses by virus
female pregnancy
virus-host interaction
cell activation
cell growth
cell death
cell cycle arrest
mitotic cell cycle G1-S transition checkpoint
positive regulation of cell cycle arrest
positive regulation of exit from mitosis
germ cell migration
negative regulation of cell cycle
negative regulation of mitotic cell cycle
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of protein kinase B signaling cascade
positive regulation of SMAD protein import into nucleus
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of MAP kinase activity
regulation of transforming growth factor beta receptor signaling pathway
regulation of cell growth
regulation of cell proliferation
MAPK cascade
protein kinase B signaling cascade
lipopolysaccharide-mediated signaling pathway
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
negative regulation of cell growth
positive regulation of cellular protein metabolic process
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein phosphorylation
positive regulation of peptidyl-threonine phosphorylation
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein dephosphorylation
positive regulation of histone deacetylation
positive regulation of histone acetylation
positive regulation of isotype switching to IgA isotypes
negative regulation of transcription, DNA-dependent
negative regulation of DNA replication
negative regulation of transcription from RNA polymerase II promoter
negative regulation of protein phosphorylation
positive regulation of NF-kappaB transcription factor activity
positive regulation of phosphatidylinositol 3-kinase activity
negative regulation of cell proliferation
negative regulation of fat cell differentiation
negative regulation of neuroblast proliferation
negative regulation of myoblast differentiation
negative regulation of T cell activation
negative regulation of T cell proliferation
negative regulation of blood vessel endothelial cell migration
negative regulation of cell-cell adhesion
negative regulation of epithelial cell proliferation
negative regulation of release of sequestered calcium ion into cytosol
negative regulation of phagocytosis
positive regulation of protein secretion
positive regulation of cell division
positive regulation of cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of cell migration
positive regulation of fibroblast migration
positive regulation of blood vessel endothelial cell migration
positive regulation of epithelial to mesenchymal transition
positive regulation of smooth muscle cell differentiation
positive regulation of apoptotic process
induction of apoptosis
positive regulation of protein import into nucleus
regulation of protein import into nucleus
regulation of cell migration
epithelial to mesenchymal transition
lens fiber cell differentiation
hematopoietic progenitor cell differentiation
chondrocyte differentiation
T cell differentiation
regulatory T cell differentiation
myeloid dendritic cell differentiation
macrophage derived foam cell differentiation
platelet activation
T cell activation
platelet degranulation
ATP biosynthetic process
receptor catabolic process
protein phosphorylation
pathway-restricted SMAD protein phosphorylation
phosphate-containing compound metabolic process
SMAD protein import into nucleus
cellular calcium ion homeostasis
cellular response to organic cyclic compound
cellular response to growth factor stimulus
cellular response to dexamethasone stimulus
myelination
cell-cell junction organization
extracellular matrix assembly
SMAD protein complex assembly
T cell homeostasis
negative regulation of macrophage cytokine production
tolerance induction to self antigen
negative regulation of immune response
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
mononuclear cell proliferation
response to organic substance
response to drug
response to organic cyclic compound
response to progesterone stimulus
response to estradiol stimulus
response to glucose stimulus
response to cholesterol
response to vitamin D
positive regulation of chemotaxis
defense response
response to hypoxia
response to wounding
inflammatory response
wound healing
response to laminar fluid shear stress
response to radiation
negative regulation of ossification
negative regulation of hyaluronan biosynthetic process
negative regulation of skeletal muscle tissue development
positive regulation of protein complex assembly
positive regulation of interleukin-17 production
positive regulation vascular endothelial growth factor production
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of collagen biosynthetic process
positive regulation of bone mineralization
regulation of cartilage development
regulation of branching involved in mammary gland duct morphogenesis
positive regulation of odontogenesis
regulation of striated muscle tissue development
positive regulation of gene expression
regulation of sodium ion transport
aging
mammary gland branching involved in thelarche
face morphogenesis
branch elongation involved in mammary gland duct branching
frontal suture morphogenesis
embryo development
digestive tract development
inner ear development
skeletal system development
ureteric bud development
lung development
mammary gland development
lymph node development
endoderm development
skeletal muscle tissue development
morphogenesis of a branching structure
organ morphogenesis
organ regeneration
salivary gland morphogenesis
ossification involved in bone remodeling
connective tissue replacement involved in inflammatory response wound healing
blood coagulation
protein export from nucleus
protein import into nucleus, translocation
hyaluronan catabolic process
viral infectious cycle
regulation of binding
regulation of DNA binding

Pathway Cell Cycle
TGFBR -> ATF/GADD/MAX/TP53 signaling
TGFBR -> CREB/ELK-SRF signaling
TGFBR -> MEF/MYOD/MYOG signaling
TGFBR -> SMAD1/5/9 signaling
TGFBR -> AP-1 signaling
TGFBR/BMPR -> SMAD2/3 signaling
Cyclosporine-Induced Nephrotoxicity
Ethanol-Induced Hepatotoxicity
MDK/PTN Expression Targets
TGFB3-TGFBR2 Expression Targets
TGFB2-TGFBR2 Expression Targets
TGFB1-TGFBR2 Expression Targets
BMP7-ACVR2 Expression Targets
INHBA-ACVR2/ACVR1 Expression Targets
MSTN-ACVR2/ACVR1 Expression Targets
BMP2-BMPR2 Expression Targets
BMP4-BMPR2 Expression Targets
BMP7-BMPR2/ACVR2 Expression Targets
NODAL-ACVR2B Expression Targets
TLR4/NF-kB/IRF Expression Targets
TLR7 Expression Targets
NTF3 Expression Targets
TNF/STAT Expression Targets
NGF/AP-1/TP53/MYC Expression Targets
NGF/SMAD3/NF-kB Expression Targets
ICAM1 Expression Targets
Fibrinogen Expression Targets
CD19 Expression Targets
IL13 Expression Targets
IL5 Expression Targets
IL9 Expression Targets
IL3 Expression Targets
Thrombopoietin/STAT Expression Targets
CSF3 Expression Targets
CNTF Expression Targets
Leptin/ELK-SRF Expression Targets
Leptin/STAT Expression Targets
CCL3 Expression Targets
CCL11 Expression Targets
NPY Expression Targets
Dopamine/Gi Expression Targets
Dronabinol/Anandamide Expression Targets
S100B Expression Targets
TGFA/CTNNB/CTNND Expression Targets
TGFA/STAT Expression Targets
TGFA/HIF1A Expression Targets
Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets
TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets
FGF9/AP-1/CREB/MYC Expression Targets
F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
F2 -> STAT1/NF-kB Expression Targets
Adenosine Expression Targets
Prostaglandin F Expression Targets
Glutamate/Gq Expression Targets
AVP/Gq -> STAT Expression Targets
AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
TAC1 Expression Targets
VIP Expression Targets
GCG Expression Targets
AVP/Gs -> STAT Expression Targets
AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets
POMC Expression Targets
CD86/STAT Expression Targets
CD86/NF-kB Expression Targets
CD86/AP-1 Expression Targets
TCR/STAT Expression Targets
TCR/AP-1 Expression Targets
FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
TCR/NF-kB Expression Targets
FGF2/STAT Expression Targets
IL1A Expression Targets
IL1B/PGE2 Expression Targets
INHBA-ACVR2/BMPR Expression Targets
TGFB1-TGFBR1 Expression Targets
TNF/NF-kB Expression Targets
PAF Expression Targets
AGT/CREB Expression Targets
AGT/STAT Expression Targets
CSF2/STAT Expression Targets
HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets
PDGF/AP-1/CREB/CREBBP/MYC Expression Targets
PDGF/STAT Expression Targets
TGFA/AP-1/ATF Expression Targets
TGFB1-ACVRL1 Expression Targets
TGFB1-TGFBR1/AP-1 Expression Targets
TNF/AP-1 Expression Targets
IL1B Expression Targets
FGF9/STAT Expression Targets
drug-gene, gene-chemical, gene-gene interaction pathway
losartan_expanded2
losartan_expanded3
losartan-gene, gene-chemical, gene-gene interaction pathway
transforming growth factor-beta Smad dependent signaling pathway
losartan-gene, gene-chemical, gene-gene interaction pathway
metformin-gene, gene-chemical, gene-gene interaction pathway
losartan-gene, gene-chemical, gene-gene interaction pathway
colorectal cancer pathway
colorectal cancer pathway

Group TGF family
cell proliferation
growth
defense response to fungus, incompatible interaction
active induction of host immune response by virus
evasion or tolerance of host defenses by virus
female pregnancy
virus-host interaction
cell activation
cell growth
cell death
cell cycle arrest
mitotic cell cycle G1-S transition checkpoint
positive regulation of cell cycle arrest
positive regulation of exit from mitosis
germ cell migration
negative regulation of cell cycle
negative regulation of mitotic cell cycle
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of protein kinase B signaling cascade
positive regulation of SMAD protein import into nucleus
positive regulation of pathway-restricted SMAD protein phosphorylation
positive regulation of MAP kinase activity
regulation of transforming growth factor beta receptor signaling pathway
regulation of cell growth
regulation of cell proliferation
MAPK cascade
protein kinase B signaling cascade
lipopolysaccharide-mediated signaling pathway
epidermal growth factor receptor signaling pathway
transforming growth factor beta receptor signaling pathway
negative regulation of cell growth
positive regulation of cellular protein metabolic process
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein phosphorylation
positive regulation of peptidyl-threonine phosphorylation
positive regulation of peptidyl-serine phosphorylation
positive regulation of protein dephosphorylation
positive regulation of histone deacetylation
positive regulation of histone acetylation
positive regulation of isotype switching to IgA isotypes
negative regulation of transcription, DNA-dependent
negative regulation of DNA replication
negative regulation of transcription from RNA polymerase II promoter
negative regulation of protein phosphorylation
positive regulation of NF-kappaB transcription factor activity
positive regulation of phosphatidylinositol 3-kinase activity
negative regulation of cell proliferation
negative regulation of fat cell differentiation
negative regulation of neuroblast proliferation
negative regulation of myoblast differentiation
negative regulation of T cell activation
negative regulation of T cell proliferation
negative regulation of blood vessel endothelial cell migration
negative regulation of cell-cell adhesion
negative regulation of epithelial cell proliferation
negative regulation of release of sequestered calcium ion into cytosol
negative regulation of phagocytosis
positive regulation of protein secretion
positive regulation of cell division
positive regulation of cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of cell migration
positive regulation of fibroblast migration
positive regulation of blood vessel endothelial cell migration
positive regulation of epithelial to mesenchymal transition
positive regulation of smooth muscle cell differentiation
positive regulation of apoptotic process
induction of apoptosis
positive regulation of protein import into nucleus
regulation of protein import into nucleus
regulation of cell migration
epithelial to mesenchymal transition
lens fiber cell differentiation
hematopoietic progenitor cell differentiation
chondrocyte differentiation
T cell differentiation
regulatory T cell differentiation
myeloid dendritic cell differentiation
macrophage derived foam cell differentiation
platelet activation
T cell activation
platelet degranulation
ATP biosynthetic process
receptor catabolic process
protein phosphorylation
pathway-restricted SMAD protein phosphorylation
phosphate-containing compound metabolic process
SMAD protein import into nucleus
cellular calcium ion homeostasis
cellular response to organic cyclic compound
cellular response to growth factor stimulus
cellular response to dexamethasone stimulus
myelination
cell-cell junction organization
extracellular matrix assembly
SMAD protein complex assembly
T cell homeostasis
negative regulation of macrophage cytokine production
tolerance induction to self antigen
negative regulation of immune response
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
mononuclear cell proliferation
response to organic substance
response to drug
response to organic cyclic compound
response to progesterone stimulus
response to estradiol stimulus
response to glucose stimulus
response to cholesterol
response to vitamin D
positive regulation of chemotaxis
defense response
response to hypoxia
response to wounding
inflammatory response
wound healing
response to laminar fluid shear stress
response to radiation
negative regulation of ossification
negative regulation of hyaluronan biosynthetic process
negative regulation of skeletal muscle tissue development
positive regulation of protein complex assembly
positive regulation of interleukin-17 production
positive regulation vascular endothelial growth factor production
positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of collagen biosynthetic process
positive regulation of bone mineralization
regulation of cartilage development
regulation of branching involved in mammary gland duct morphogenesis
positive regulation of odontogenesis
regulation of striated muscle tissue development
positive regulation of gene expression
regulation of sodium ion transport
aging
mammary gland branching involved in thelarche
face morphogenesis
branch elongation involved in mammary gland duct branching
frontal suture morphogenesis
embryo development
digestive tract development
inner ear development
skeletal system development
ureteric bud development
lung development
mammary gland development
lymph node development
endoderm development
skeletal muscle tissue development
morphogenesis of a branching structure
organ morphogenesis
organ regeneration
salivary gland morphogenesis
ossification involved in bone remodeling
connective tissue replacement involved in inflammatory response wound healing
blood coagulation
protein export from nucleus
protein import into nucleus, translocation
hyaluronan catabolic process
viral infectious cycle
regulation of binding
regulation of DNA binding
protein N-terminus binding
enzyme binding
growth factor activity
transforming growth factor beta receptor binding
type II transforming growth factor beta receptor binding
protein homodimerization activity
protein heterodimerization activity
eukaryotic cell surface binding
extracellular matrix
extracellular region
Golgi lumen
platelet alpha granule lumen
cell surface
cytoplasm
secretory granule
nucleus
microvillus
axon
neuronal cell body
extracellular space
proteinaceous extracellular matrix
Secreted proteins
Biofluids assayable substances

Source Curated

MedScan ID 7040

Hugo ID 11766

Human chromosome position 19q13.1
19q13.2

GenBank ID NC_000019
NM_000660
NP_000651
NG_013364
NC_018930
AC_000151
AC011462
AY059373
AAL27646
AY330201
AAQ18641
AY330202
AAQ18642
AY576687
AAT77143
AY576688
AAT77144
AY871232
AAX59016
AY871233
AAX59017
AY871234
AAX59018
AY871235
AAX59019
AY871236
AAX59020
AY871237
AAX59021
AY871238
AAX59022
AY871239
AAX59023
AY871240
AAX59024
AY871241
AAX59025
AY871242
AAX59026
AY871243
AAX59027
AY871244
AAX59028
AY871245
AAX59029
CH471126
EAW57032
EAW57033
CQ759646
CAF32686
CS674262
CAP12291
CS805735
CAP40172
HC919732
CBN73463
HC919943
CBN73468
JA104601
CCA63970
X05839
CAA29283
AI304490
AK291907
BAF84596
AK307742
AY820829
AAV71148
BC000125
AAH00125
BC001180
AAH01180
BC022242
AAH22242
BP267938
BT007245
AAP35909
DA935180
M38449
AAA36735
X02812
CAA26580
P01137
EU832132
ACE87482
EU832225
ACE86795
NC_000073
NM_011577
NP_035707
AC_000029
AC162614
AY340221
AAR06153
AY342403
AAQ75558
CH466593
EDL24239
L42456
AAB00138
L42457
L42458
L42459
L42460
L42461
L42462
AJ009862
CAA08900
AK144163
BAE25742
BC013738
AAH13738
M13177
AAA40423
P04202
NC_005100
NM_021578
NP_067589
AC_000069
AF105069
AAD20222
CH473979
EDM07998
AY550025
AAS55640
BC076380
AAH76380
X52498
CAA36741
P17246
NT_011109
NW_927217
NW_001838496
AC_000062
CR592182
CR601792
CR612251
Q49IK8
Q49IL8
Q5PY19
Q671U8
Q671V1
Q7Z487
Q7Z488
Q86YU2
NT_039413
NW_001030836
Q3UNK5
NW_047556
NW_001084763
Q9R231
NT_039438
Q53YM8
NW_000303

LocusLink ID 7040
21803
59086
43846

Alias CED
LAP
DPD1
TGFB
TGFbeta
transforming growth factor beta-1
TGF-beta-1
TGF-beta 1 protein
latency-associated peptide
Tgfb-1
TGFbeta1
TGF-beta1
TGF-beta 1
regulatory protein
transforming growth factor-beta 1
transforming growth factor, beta-1
transforming growth factor beta
transforming growth factor (TGF)-beta
TGF-beta I
TGFB1
Transforming growth factor beta 1
TGF1_RAT
TGF eta
TGF beta
Camurati-Engelmann disease protein
Camurati-Engelmann disease gene
beta 1 transforming growth factor
Tgfb I
TGF1_HUMAN
diaphyseal dysplasia 1, progressive
DPD I
transforming growth factor, beta
transforming growth factor, beta 1
Transforming growth factor beta 1 precursor
transforming growth factor, beta 1 (Camurati-Engelmann disease)
diaphyseal dysplasia 1, progressive (Camurati-Engelmann disease)
Camurati-Engelmann disease

Organism Homo sapiens
Mus musculus
Rattus norvegicus

OMIM ID 190180
219700
131300

Unigene ID Hs.645227
Mm.248380
Rn.40136
Hs.155218
Hs.1103

KEGG ID hsa:7040
mmu:21803
rno:59086

Swiss-Prot Accession P01137
P04202
Q3UNK5
P17246
A8K792
Q9UCG4
Q53YM8
Q49IK8
Q49IL8
Q5PY19
Q671U8
Q671V1
Q7Z487
Q7Z488
Q86YU2
Q9R231

GO ID 0019899
0043499
0008083
0047485
0046982
0042803
0005114
0006754
0000165
0007183
0007184
0043029
0046732
0002460
0007568
0007596
0060751
0007050
0008219
0016049
0045216
0006874
0071549
0071363
0071407
0002062
0002248
0009817
0048565
0009790
0007492
0007173
0001837
0019049
0085029
0060325
0007565
0060364
0008354
0002244
0030214
0006917
0006954
0048839
0070306
0031663
0048535
0010742
0060744
0031575
0032943
0042552
0043011
0008156
0042130
0043537
0045786
0030308
0008285
0022408
0050680
0045599
1900126
0050777
0010936
0045930
0045662
0007406
0030279
0050765
0001933
0051280
0048642
0000122
0045892
0030512
0031100
0043932
0060389
0006796
0030168
0002576
0043406
0051092
0060391
0043536
0030501
0090190
0071158
0051781
0030335
0008284
0032270
0050921
0032967
0050679
0010718
0031536
0010763
0010628
0035066
0031065
0032740
0048298
0042482
0010862
0033138
0010800
0043552
0031334
0035307
0042307
0051897
0001934
0050714
0051152
0045944
0045893
0010575
0006611
0000060
0043491
0006468
0032801
0051101
0051098
0060762
0061035
0030334
0042306
0002028
0016202
0017015
0045066
0070723
0042493
0032355
0009749
0001666
0034616
0032570
0009314
0033280
0009611
0007435
0002513
0007179
0001657
0019058
0019048
0005796
0030424
0009986
0005737
0005576
0005615
0005902
0043025
0005634
0031093
0005578
0005160
0042110
0030217
0001775
0008283
0006952
0040007
0030879
0001763
0050868
0009887
0043065
0042127
0010033
0007519
0001501
0042060
0031012
0030141
0030324
0001558
0014070
0016563
0016481
0043193
0010552
0045941
0051789
0042476
0045595
0005515
0006916
0000074
0007267

PIR ID A27513
A01396
S10219

Swiss-Prot ID TGFB1_HUMAN
TGFB1_MOUSE
TGFB1_RAT
Q3UNK5_MOUSE

Cell Localization Secreted
extracellular space
extracellular matrix
Extracellular

IPI ID IPI00000075
IPI00114457
IPI00214538

Mouse chromosome position 7 6.5 cM

Rat chromosome position 1q22

Homologene ID 540

MGI ID 98725

RGD ID 69051

Primary Cell Localization Extracellular

KEGG pathway Cell cycle
MAPK signaling pathway
TGF-beta signaling pathway