Protein Msh2

URN	urn:agi-llid:4436
Connectivity	163
Name	Msh2
Description	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Notes	MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.

Pathway	colorectal cancer pathway

GO Molecular Function	nucleotide binding
	protein C-terminus binding
	DNA binding
	protein homodimerization activity
	MutLalpha complex binding
	ADP binding
	ATP binding
	damaged DNA binding
	double-stranded DNA binding
	single-stranded DNA binding
	centromeric DNA binding
	mismatched DNA binding
	four-way junction DNA binding
	guanine-thymine mispair binding
	dinucleotide insertion or deletion binding
	single thymine insertion binding
	single guanine insertion binding
	dinucleotide repeat insertion binding
	oxidized purine DNA binding
	magnesium ion binding
	ATPase activity

GO Biological Process	cell cycle
	determination of adult lifespan
	germ cell development
	male gonad development
	B cell differentiation
	in utero embryonic development
	spermatogenesis
	cell cycle arrest
	intra-S DNA damage checkpoint
	negative regulation of DNA recombination
	negative regulation of apoptosis
	negative regulation of neuron apoptosis
	isotype switching
	oxidative phosphorylation
	DNA repair
	maintenance of DNA repeat elements
	mismatch repair
	postreplication repair
	double-strand break repair
	somatic recombination of immunoglobulin gene segments
	somatic recombination of immunoglobulin genes during immune response
	response to DNA damage stimulus
	apoptosis
	B cell mediated immunity
	somatic hypermutation of immunoglobulin genes
	response to drug
	response to amino acid stimulus
	response to organic cyclic substance
	response to X-ray
	response to UV-B
	positive regulation of helicase activity

Ariadne Ontology	DNA repair

Group	DNA repair
	cell cycle
	determination of adult lifespan
	germ cell development
	male gonad development
	B cell differentiation
	in utero embryonic development
	spermatogenesis
	cell cycle arrest
	intra-S DNA damage checkpoint
	negative regulation of DNA recombination
	negative regulation of apoptosis
	negative regulation of neuron apoptosis
	isotype switching
	oxidative phosphorylation
	DNA repair
	maintenance of DNA repeat elements
	mismatch repair
	postreplication repair
	double-strand break repair
	somatic recombination of immunoglobulin gene segments
	somatic recombination of immunoglobulin genes during immune response
	response to DNA damage stimulus
	apoptosis
	B cell mediated immunity
	somatic hypermutation of immunoglobulin genes
	response to drug
	response to amino acid stimulus
	response to organic cyclic substance
	response to X-ray
	response to UV-B
	positive regulation of helicase activity
	nucleotide binding
	protein C-terminus binding
	DNA binding
	protein homodimerization activity
	MutLalpha complex binding
	ADP binding
	ATP binding
	damaged DNA binding
	double-stranded DNA binding
	single-stranded DNA binding
	centromeric DNA binding
	mismatched DNA binding
	four-way junction DNA binding
	guanine-thymine mispair binding
	dinucleotide insertion or deletion binding
	single thymine insertion binding
	single guanine insertion binding
	dinucleotide repeat insertion binding
	oxidized purine DNA binding
	magnesium ion binding
	ATPase activity
	MutSbeta complex
	MutSalpha complex
	nucleus

MedScan ID	4436

Hugo ID	7325

Human chromosome position	2p22-p21

Alias	FCC1
	COCA1
	HNPCC
	LCFS2
	HNPCC1
	DNA mismatch repair protein Msh2
	hMSH2
	OTTHUMP00000200306
	mutS protein homolog 2
	AI788990
	mismatch repair protein
	COCA I
	colon cancer, nonpolyposis type 1
	colon cancer, nonpolyposis type I
	FCC I
	HNPCC I
	LCFS2 gene
	LCFS2 protein
	Lynch cancer family syndrome 2 gene
	Lynch cancer family syndrome 2 protein
	Lynch cancer family syndrome II gene
	Lynch cancer family syndrome II protein
	mismatch repair protein 2
	mismatch repair protein II
	Msh2
	mutS (E. coli) homolog 2
	mutS (E. coli) homolog II
	mutS homolog 2
	mutS homolog 2 (E. coli)
	mutS homolog 2, colon cancer, nonpolyposis type 1
	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
	mutS homolog II
	HNPCC1s
	HNPCC Is

Mouse chromosome position	17 45.9 cM

Rat chromosome position	6q12

Cell Localization	Nucleus

Homologene ID	210

RGD ID	620786

MGI ID	101816