Protein MSH6

URN	urn:agi-llid:2956
Connectivity	84
Name	MSH6
Description	mutS homolog 6 (E. coli)
Notes	This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Pathway	colorectal cancer pathway

GO Molecular Function	nucleotide binding
	chromatin binding
	DNA binding
	protein homodimerization activity
	MutLalpha complex binding
	ADP binding
	ATP binding
	damaged DNA binding
	double-stranded DNA binding
	mismatched DNA binding
	four-way junction DNA binding
	guanine-thymine mispair binding
	single thymine insertion binding
	single guanine insertion binding
	oxidized purine DNA binding
	magnesium ion binding
	ATPase activity

GO Biological Process	determination of adult lifespan
	meiotic mismatch repair
	negative regulation of DNA recombination
	induction of apoptosis by intracellular signals
	DNA damage response, signal transduction resulting in induction of apoptosis
	isotype switching
	DNA repair
	maintenance of DNA repeat elements
	mismatch repair
	somatic recombination of immunoglobulin gene segments
	response to DNA damage stimulus
	somatic hypermutation of immunoglobulin genes
	response to UV
	positive regulation of helicase activity

Ariadne Ontology	DNA repair

Group	DNA repair
	determination of adult lifespan
	meiotic mismatch repair
	negative regulation of DNA recombination
	induction of apoptosis by intracellular signals
	DNA damage response, signal transduction resulting in induction of apoptosis
	isotype switching
	DNA repair
	maintenance of DNA repeat elements
	mismatch repair
	somatic recombination of immunoglobulin gene segments
	response to DNA damage stimulus
	somatic hypermutation of immunoglobulin genes
	response to UV
	positive regulation of helicase activity
	nucleotide binding
	chromatin binding
	DNA binding
	protein homodimerization activity
	MutLalpha complex binding
	ADP binding
	ATP binding
	damaged DNA binding
	double-stranded DNA binding
	mismatched DNA binding
	four-way junction DNA binding
	guanine-thymine mispair binding
	single thymine insertion binding
	single guanine insertion binding
	oxidized purine DNA binding
	magnesium ion binding
	ATPase activity
	MutSalpha complex
	nuclear chromatin
	nucleus

MedScan ID	2956

Hugo ID	7329

Human chromosome position	2p16

LocusLink ID	2956
	17688

Alias	GTBP
	HSAP
	HNPCC5
	DNA mismatch repair protein Msh6
	p160
	GTMBP
	hMSH6
	sperm-associated protein
	mutS-alpha 160 kDa subunit
	G/T mismatch-binding protein
	AU044881
	AW550279
	G/T mismatch binding protein
	human sperm associated protein
	human sperm-associated protein
	Msh6
	mutS (E. coli) homolog 6
	mutS (E. coli) homolog VI
	mutS homolog 6
	mutS homolog 6 (E. coli)
	mutS homolog VI
	mutS homolog
	G/T mismatch binding protein
	HNPCC5s

Organism	Homo sapiens
	Mus musculus

Mouse chromosome position	17 47.0 cM

PIR ID	JC5839

Unigene ID	Hs.445052
	Mm.18210

KEGG ID	hsa:2956
	mmu:17688

Cell Localization	Nucleus

Homologene ID	149

RGD ID	1321738

MGI ID	1343961