| URN | urn:agi-llid:324 |
|---|---|
| Connectivity | 348 |
| Name | APC |
| Description | adenomatous polyposis coli |
| Notes | This gene encodes a tumor suppressor protein that includes among its many intracellular functions one of nuclear export. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. |
| Pathway | colorectal cancer pathway |
|---|
| GO Molecular Function | beta-catenin binding |
|---|---|
| gamma-catenin binding | |
| cadherin binding | |
| protein kinase binding | |
| microtubule binding | |
| microtubule plus-end binding | |
| protein kinase regulator activity |
| GO Cellular Component | cell projection |
|---|---|
| neuron projection | |
| growth cone | |
| cytoplasm | |
| axon part | |
| cell projection membrane | |
| Axin-APC-beta-catenin-GSK3B complex | |
| cytosol | |
| beta-catenin destruction complex | |
| cytoplasmic microtubule | |
| centrosome | |
| kinetochore | |
| microtubule | |
| nucleus | |
| cell junction | |
| lateral plasma membrane | |
| cell-cell adherens junction | |
| adherens junction | |
| tight junction |
| GO Biological Process | cell adhesion |
|---|---|
| negative regulation of cell proliferation | |
| establishment or maintenance of cell polarity | |
| pattern specification process | |
| stem cell maintenance | |
| somatic stem cell maintenance | |
| positive regulation of cell differentiation | |
| retina development in camera-type eye | |
| regulation of cell differentiation | |
| axis specification | |
| negative regulation of odontogenesis | |
| regulation of osteoblast differentiation | |
| anterior-posterior pattern formation | |
| proximal-distal pattern formation | |
| dorsal-ventral pattern formation | |
| kidney development | |
| thymus development | |
| skin development | |
| hair follicle development | |
| axonogenesis | |
| regulation of epithelial cell differentiation | |
| positive regulation of epithelial cell differentiation | |
| T cell differentiation in the thymus | |
| regulation of osteoclast differentiation | |
| negative regulation of epithelial cell proliferation involved in prostate gland development | |
| muscle cell homeostasis | |
| regulation of cell cycle | |
| chromosome organization | |
| mitotic metaphase-anaphase transition | |
| cell cycle arrest | |
| positive regulation of cell adhesion | |
| positive regulation of cell division | |
| neuron projection development | |
| cytokinesis after mitosis | |
| mitotic cell cycle spindle assembly checkpoint | |
| regulation of attachment of spindle microtubules to kinetochore | |
| positive regulation of microtubule polymerization | |
| negative regulation of microtubule depolymerization | |
| negative regulation of cyclin-dependent protein kinase activity | |
| negative regulation of MAPKKK cascade | |
| negative regulation of Wnt receptor signaling pathway | |
| negative regulation of Wnt receptor signaling pathway through beta-catenin | |
| regulation of cell migration | |
| negative regulation of epithelial cell proliferation | |
| positive regulation of pseudopodium assembly | |
| positive regulation of cell migration | |
| positive regulation of apoptosis | |
| negative regulation of apoptosis | |
| regulation of apoptosis | |
| cell migration | |
| response to DNA damage stimulus | |
| tight junction assembly | |
| response to drug | |
| regulation of nitrogen compound metabolic process | |
| positive regulation of protein catabolic process | |
| protein complex assembly | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway through beta-catenin |
| Ariadne Ontology | Tumor suppressors |
|---|
| Group | Tumor suppressors |
|---|---|
| cell adhesion | |
| negative regulation of cell proliferation | |
| establishment or maintenance of cell polarity | |
| pattern specification process | |
| stem cell maintenance | |
| somatic stem cell maintenance | |
| positive regulation of cell differentiation | |
| retina development in camera-type eye | |
| regulation of cell differentiation | |
| axis specification | |
| negative regulation of odontogenesis | |
| regulation of osteoblast differentiation | |
| anterior-posterior pattern formation | |
| proximal-distal pattern formation | |
| dorsal-ventral pattern formation | |
| kidney development | |
| thymus development | |
| skin development | |
| hair follicle development | |
| axonogenesis | |
| regulation of epithelial cell differentiation | |
| positive regulation of epithelial cell differentiation | |
| T cell differentiation in the thymus | |
| regulation of osteoclast differentiation | |
| negative regulation of epithelial cell proliferation involved in prostate gland development | |
| muscle cell homeostasis | |
| regulation of cell cycle | |
| chromosome organization | |
| mitotic metaphase-anaphase transition | |
| cell cycle arrest | |
| positive regulation of cell adhesion | |
| positive regulation of cell division | |
| neuron projection development | |
| cytokinesis after mitosis | |
| mitotic cell cycle spindle assembly checkpoint | |
| regulation of attachment of spindle microtubules to kinetochore | |
| positive regulation of microtubule polymerization | |
| negative regulation of microtubule depolymerization | |
| negative regulation of cyclin-dependent protein kinase activity | |
| negative regulation of MAPKKK cascade | |
| negative regulation of Wnt receptor signaling pathway | |
| negative regulation of Wnt receptor signaling pathway through beta-catenin | |
| regulation of cell migration | |
| negative regulation of epithelial cell proliferation | |
| positive regulation of pseudopodium assembly | |
| positive regulation of cell migration | |
| positive regulation of apoptosis | |
| negative regulation of apoptosis | |
| regulation of apoptosis | |
| cell migration | |
| response to DNA damage stimulus | |
| tight junction assembly | |
| response to drug | |
| regulation of nitrogen compound metabolic process | |
| positive regulation of protein catabolic process | |
| protein complex assembly | |
| Wnt receptor signaling pathway | |
| Wnt receptor signaling pathway through beta-catenin | |
| beta-catenin binding | |
| gamma-catenin binding | |
| cadherin binding | |
| protein kinase binding | |
| microtubule binding | |
| microtubule plus-end binding | |
| protein kinase regulator activity | |
| cell projection | |
| neuron projection | |
| growth cone | |
| cytoplasm | |
| axon part | |
| cell projection membrane | |
| Axin-APC-beta-catenin-GSK3B complex | |
| cytosol | |
| beta-catenin destruction complex | |
| cytoplasmic microtubule | |
| centrosome | |
| kinetochore | |
| microtubule | |
| nucleus | |
| cell junction | |
| lateral plasma membrane | |
| cell-cell adherens junction | |
| adherens junction | |
| tight junction |
| MedScan ID | 324 |
|---|
| Hugo ID | 583 |
|---|
| Human chromosome position | 5q21-q22 |
|---|
| LocusLink ID | 324 |
|---|---|
| 11789 | |
| 24205 |
| Alias | GS |
|---|---|
| DP2 | |
| DP3 | |
| BTPS2 | |
| DP2.5 | |
| adenomatous polyposis coli protein | |
| deleted in polyposis 2.5 | |
| adenomatosis polyposis coli tumor suppressor | |
| CC1 | |
| Min | |
| mAPC | |
| AI047805 | |
| AU020952 | |
| AW124434 | |
| multiple intestinal neoplasia | |
| RATAPC | |
| adenomatosis polyposis coli | |
| adenomatosis polyposis coli gene | |
| Adenomatosis polyposis coli protein | |
| adenomatosis polyposis coli tumour suppressor | |
| adenomatous polyposis coli | |
| adenomatous polyposis coli gene | |
| APC adenomatous polyposis coli protein | |
| APC gene | |
| APC protein | |
| APC tumor suppressor | |
| APC tumour suppressor | |
| Min protein | |
| multiple intestinal neoplasia gene | |
| multiple intestinal neoplasia protein | |
| protein Min | |
| tumor suppressor APC | |
| tumour suppressor APC |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 611731 |
|---|---|
| 175100 | |
| 114500 | |
| 137215 | |
| 135290 | |
| 155255 | |
| 276300 |
| Mouse chromosome position | 18 15.0 cM |
|---|
| GO ID | 0008013 |
|---|---|
| 0045296 | |
| 0045295 | |
| 0008017 | |
| 0051010 | |
| 0019901 | |
| 0019887 | |
| 0033077 | |
| 0060070 | |
| 0009952 | |
| 0009798 | |
| 0007409 | |
| 0007155 | |
| 0007050 | |
| 0051276 | |
| 0000281 | |
| 0009953 | |
| 0007163 | |
| 0001942 | |
| 0001822 | |
| 0007094 | |
| 0007091 | |
| 0046716 | |
| 0043409 | |
| 0090090 | |
| 0043066 | |
| 0008285 | |
| 0045736 | |
| 0060770 | |
| 0007026 | |
| 0042483 | |
| 0031175 | |
| 0043065 | |
| 0045785 | |
| 0051781 | |
| 0030335 | |
| 0030858 | |
| 0031116 | |
| 0045732 | |
| 0031274 | |
| 0006461 | |
| 0009954 | |
| 0051988 | |
| 0051726 | |
| 0051171 | |
| 0045667 | |
| 0045670 | |
| 0006974 | |
| 0042493 | |
| 0060041 | |
| 0043588 | |
| 0035019 | |
| 0048538 | |
| 0070830 | |
| 0034747 | |
| 0033267 | |
| 0030877 | |
| 0030054 | |
| 0031253 | |
| 0005913 | |
| 0005813 | |
| 0005737 | |
| 0005881 | |
| 0005829 | |
| 0030426 | |
| 0000776 | |
| 0016328 | |
| 0005634 | |
| 0005923 | |
| 0016055 | |
| 0016477 | |
| 0030178 | |
| 0050680 | |
| 0007389 | |
| 0045597 | |
| 0042981 | |
| 0045595 | |
| 0030334 | |
| 0030856 | |
| 0019827 | |
| 0042995 | |
| 0005874 | |
| 0043005 | |
| 0005912 | |
| 0005488 | |
| 0005515 | |
| 0007049 | |
| 0045786 | |
| 0008605 |
| Rat chromosome position | 18p12 |
|---|
| Swiss-Prot Accession | P25054 |
|---|---|
| Q4LE70 | |
| Q16097 | |
| Q5EBR9 | |
| Q5EEK4 | |
| Q6B4H6 | |
| Q7Z2Q8 | |
| Q9HAW6 | |
| Q9P119 | |
| Q9UM98 | |
| B2RUG9 | |
| Q8BNP7 | |
| Q3UQT2 | |
| Q61315 | |
| Q8BRD8 | |
| Q8C493 | |
| Q8C9I9 | |
| P70478 | |
| Q15162 | |
| Q15163 | |
| Q93042 |
| PIR ID | A37261 |
|---|
| Unigene ID | Hs.158932 |
|---|---|
| Mm.384171 | |
| Rn.88057 | |
| Hs.707997 |
| KEGG ID | hsa:324 |
|---|---|
| mmu:11789 | |
| rno:24205 |
| Swiss-Prot ID | APC_RAT |
|---|---|
| APC_HUMAN | |
| B2RUG9_MOUSE | |
| Q8BNP7_MOUSE | |
| Q4LE70_HUMAN |
| Cell Localization | Cell junction |
|---|---|
| adherens junction |
| IPI ID | IPI00188859 |
|---|---|
| IPI00012391 | |
| IPI00215877 | |
| IPI00896736 | |
| IPI00119913 | |
| IPI00468234 | |
| IPI00229891 | |
| IPI00229894 | |
| IPI00404984 | |
| IPI00778481 |
| Homologene ID | 30950 |
|---|
| RGD ID | 2123 |
|---|
| MGI ID | 88039 |
|---|