Elsevier Inc. cisplatin_DNA_adducts ---| Colorectal Neoplasms Axin2 Ctnnb1 Axin1 Apc altered Wnt signaling, canonical pathway Tgfbr2 Tgfbr1 Tgfb1 Smad3 Smad4 Smad2 altered transforming growth factor-beta Smad dependent signaling pathway upregulated miRNA ---> downregulated target translation upregulated target translation downregulated target translation cisplatin_DNA_adducts abnormal Watson-Crick pairing Mlh1 Msh2 Msh6 Pms1 Pms2 altered mismatch repair pathway altered expression of target genes potential CRC miRNA ---> Colorectal Neoplasms downregulated miRNA ---> upregulated target translation cisplatin drug pathway Braf Kras altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered mismatch repair pathway ---> abnormal Watson-Crick pairing altered Wnt signaling, canonical pathway ---> altered expression of target genes altered transforming growth factor-beta Smad dependent signaling pathway ---> altered expression of target genes altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes potential CRC miRNA upregulated miRNA downregulated miRNA cisplatin drug pathway ---> cisplatin_DNA_adducts Colorectal Neoplasms