| URN | urn:agi-llid:707 |
|---|---|
| Connectivity | 856 |
| Name | Pten |
| Description | phosphatase and tensin homolog |
| Notes | may be involved in regulation of phosphoinositide 3-kinase and Akt kinase mediated antiapoptotic pathways [RGD] |
| Pathway | phosphatidylinositol 3-kinase-Akt signaling pathway |
|---|---|
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| prostate cancer pathway | |
| endometrial cancer pathway | |
| non-small cell lung cancer pathway |
| GO Molecular Function | lipid binding |
|---|---|
| hydrolase activity | |
| PDZ domain binding | |
| platelet-derived growth factor receptor binding | |
| magnesium ion binding | |
| phosphatase activity | |
| inositol or phosphatidylinositol phosphatase activity | |
| phosphoprotein phosphatase activity | |
| phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | |
| phosphatidylinositol-3-phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| protein tyrosine phosphatase activity | |
| protein tyrosine-serine-threonine phosphatase activity | |
| inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| mitochondrion | |
| nucleus |
| GO Biological Process | cell proliferation |
|---|---|
| negative regulation of cell proliferation | |
| aging | |
| prostate gland growth | |
| angiogenesis | |
| nervous system development | |
| central nervous system development | |
| heart development | |
| regulation of neuron projection development | |
| cardiac muscle tissue development | |
| memory | |
| regulation of cell cycle | |
| neuron projection development | |
| regulation of cyclin-dependent protein kinase activity | |
| negative regulation of protein kinase B signaling cascade | |
| negative regulation of epithelial cell proliferation | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| negative regulation of cell migration | |
| negative regulation of phagocytosis | |
| negative regulation of focal adhesion assembly | |
| negative regulation of apoptosis | |
| regulation of myeloid cell apoptosis | |
| regulation of B cell apoptosis | |
| cell migration | |
| endothelial cell migration | |
| inositol phosphate dephosphorylation | |
| protein amino acid dephosphorylation | |
| phosphoinositide dephosphorylation | |
| dephosphorylation | |
| apoptosis | |
| response to organic substance | |
| response to drug | |
| response to inorganic substance | |
| response to nutrient | |
| response to arsenic | |
| response to organic cyclic substance | |
| response to ATP | |
| response to ethanol | |
| response to zinc ion | |
| response to estradiol stimulus | |
| response to glucose stimulus | |
| regulation of protein stability | |
| lipid metabolic process | |
| platelet-derived growth factor receptor signaling pathway |
| Ariadne Ontology | PTEN |
|---|---|
| Tumor suppressors |
| Group | PTEN |
|---|---|
| Tumor suppressors | |
| cell proliferation | |
| negative regulation of cell proliferation | |
| aging | |
| prostate gland growth | |
| angiogenesis | |
| nervous system development | |
| central nervous system development | |
| heart development | |
| regulation of neuron projection development | |
| cardiac muscle tissue development | |
| memory | |
| regulation of cell cycle | |
| neuron projection development | |
| regulation of cyclin-dependent protein kinase activity | |
| negative regulation of protein kinase B signaling cascade | |
| negative regulation of epithelial cell proliferation | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| negative regulation of cell migration | |
| negative regulation of phagocytosis | |
| negative regulation of focal adhesion assembly | |
| negative regulation of apoptosis | |
| regulation of myeloid cell apoptosis | |
| regulation of B cell apoptosis | |
| cell migration | |
| endothelial cell migration | |
| inositol phosphate dephosphorylation | |
| protein amino acid dephosphorylation | |
| phosphoinositide dephosphorylation | |
| dephosphorylation | |
| apoptosis | |
| response to organic substance | |
| response to drug | |
| response to inorganic substance | |
| response to nutrient | |
| response to arsenic | |
| response to organic cyclic substance | |
| response to ATP | |
| response to ethanol | |
| response to zinc ion | |
| response to estradiol stimulus | |
| response to glucose stimulus | |
| regulation of protein stability | |
| lipid metabolic process | |
| platelet-derived growth factor receptor signaling pathway | |
| lipid binding | |
| hydrolase activity | |
| PDZ domain binding | |
| platelet-derived growth factor receptor binding | |
| magnesium ion binding | |
| phosphatase activity | |
| inositol or phosphatidylinositol phosphatase activity | |
| phosphoprotein phosphatase activity | |
| phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | |
| phosphatidylinositol-3-phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| protein tyrosine phosphatase activity | |
| protein tyrosine-serine-threonine phosphatase activity | |
| inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus |
| MedScan ID | 707 |
|---|---|
| 5728 |
| Hugo ID | 9588 |
|---|
| Human chromosome position | 10q23.3 |
|---|
| LocusLink ID | 707 |
|---|---|
| 5728 | |
| 19211 | |
| 50557 | |
| 4260 | |
| 70161 | |
| 107201 | |
| 29420 | |
| 368415 | |
| 322802 | |
| 325503 | |
| 327192 | |
| 334970 | |
| 335216 |
| Alias | BZS |
|---|---|
| DEC | |
| GLM2 | |
| MHAM | |
| TEP1 | |
| MMAC1 | |
| PTEN1 | |
| 10q23del | |
| MGC11227 | |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | |
| mutated in multiple advanced cancers 1 | |
| MMAC1 phosphatase and tensin homolog deleted on chromosome 10 | |
| AI463227 | |
| MGC183880 | |
| 2310035O07Rik | |
| A130070J02Rik | |
| B430203M17Rik | |
| OTTMUSP00000023423 | |
| Mmac | |
| protein tyrosine phosphatase and tensin-like protein | |
| phosphatase and tensin homolog deleted on chromosome ten | |
| PTEN/MMAC1 | |
| 2310035O07 | |
| A130070J02 | |
| B430203M17 | |
| Bannayan-Zonana syndrome gene | |
| Bannayan-Zonana syndrome protein | |
| Chromosome 10q23 deletion syndrome | |
| Deleted in endometrial carcinoma | |
| MMAC I | |
| multiple hamartoma (Cowden syndrome) gene | |
| multiple hamartoma gene | |
| multiple hamartoma protein | |
| Mutated in multiple advanced cancers I | |
| OTTHUMP00000020032 | |
| phosphatase and tensin homolog | |
| phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | |
| Protein-tyrosine phosphatase PTEN | |
| PTEN | |
| PTEN I | |
| tensin homolog | |
| TEP I | |
| RIKEN cDNA 2310035O07 gene | |
| Mutated in multiple advanced cancers 1 | |
| Mutated in multiple advanced cancers I | |
| multiple hamartoma | |
| phosphatase and tensin homologue | |
| MMAC1 phosphatase and tension homolog deleted on chromosome 10 | |
| fb73f10 | |
| wu:fb73f10 | |
| fc83f12 | |
| wu:fc83f12 | |
| fd16b10 | |
| wu:fd16b10 | |
| fa11a08 | |
| wu:fa11a08 | |
| fk90e11 | |
| wu:fk90e11 | |
| MGC123112 | |
| chromosome | |
| phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) | |
| ptenb | |
| scaffold | |
| si:bz1g13.4 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Danio rerio |
| OMIM ID | 601728 |
|---|---|
| 153480 | |
| 612242 | |
| 158350 | |
| 608089 | |
| 613028 | |
| 174900 | |
| 605309 | |
| 155600 | |
| 607174 | |
| 137800 | |
| 176807 | |
| 176920 | |
| 275355 | |
| 188470 | |
| 276950 |
| Mouse chromosome position | 19 24.5 cM |
|---|
| GO ID | 0030165 |
|---|---|
| 0016787 | |
| 0051717 | |
| 0008289 | |
| 0000287 | |
| 0016314 | |
| 0051800 | |
| 0004438 | |
| 0005161 | |
| 0004722 | |
| 0004725 | |
| 0008138 | |
| 0007568 | |
| 0001525 | |
| 0048738 | |
| 0016477 | |
| 0008283 | |
| 0007417 | |
| 0043542 | |
| 0007507 | |
| 0006917 | |
| 0046855 | |
| 0006629 | |
| 0007613 | |
| 0043066 | |
| 0030336 | |
| 0008285 | |
| 0050680 | |
| 0051895 | |
| 0050765 | |
| 0051898 | |
| 0046856 | |
| 0048008 | |
| 0060736 | |
| 0006470 | |
| 0002902 | |
| 0000079 | |
| 0033032 | |
| 0010975 | |
| 0031647 | |
| 0033198 | |
| 0046685 | |
| 0042493 | |
| 0032355 | |
| 0045471 | |
| 0009749 | |
| 0007584 | |
| 0014070 | |
| 0010043 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0005634 | |
| 0004437 | |
| 0016791 | |
| 0004721 | |
| 0006915 | |
| 0016311 | |
| 0007399 | |
| 0031175 | |
| 0043065 | |
| 0051726 | |
| 0010035 | |
| 0010033 | |
| 0005515 | |
| 0045786 | |
| 0007049 | |
| 0001568 | |
| 0031174 | |
| 0042577 | |
| 0051896 |
| Rat chromosome position | 1q41-q43 |
|---|
| Swiss-Prot Accession | P60484 |
|---|---|
| O08586 | |
| Q3UUT8 | |
| Q3UUN5 | |
| Q8BJP9 | |
| Q8BSR7 | |
| O54857 | |
| Q812B9 | |
| B2R904 | |
| O00633 | |
| O02679 | |
| Q6ICT7 | |
| Q3UFB0 | |
| Q542G1 |
| Unigene ID | Hs.500466 |
|---|---|
| Mm.245395 | |
| Mm.444861 | |
| Rn.22158 | |
| Hs.592504 | |
| Mm.244179 | |
| Mm.393980 | |
| Mm.220979 | |
| Dr.140568 | |
| Mm.440799 |
| KEGG ID | hsa:5728 |
|---|---|
| mmu:19211 | |
| rno:50557 |
| EC Number | 3.1.3.67 |
|---|---|
| 3.1.3.16 | |
| 3.1.3.48 |
| Swiss-Prot ID | PTEN_HUMAN |
|---|---|
| PTEN_MOUSE | |
| O54857_RAT | |
| Q3UUT8_MOUSE | |
| B2R904_HUMAN | |
| Q8BJP9_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00012587 |
|---|---|
| IPI00114410 | |
| IPI00199035 | |
| IPI00652977 | |
| IPI00222440 |
| Homologene ID | 265 |
|---|
| RGD ID | 61995 |
|---|
| MGI ID | 109583 |
|---|---|
| 1917411 | |
| 2147557 |
| Microarray ID | 160614_at |
|---|---|
| 94988_at | |
| 94989_at | |
| 222176_at | |
| 233254_x_at | |
| 225363_at | |
| 1454722_at | |
| 1455728_at |
| FunctionalClass | PDZ domain binding |
|---|---|
| hydrolase | |
| inositol-1,3,4,5-tetrakisphosphate 3-phosphatase | |
| phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | |
| phosphatidylinositol-3,4-bisphosphate 3-phosphatase | |
| phosphatidylinositol-3-phosphatase | |
| protein binding | |
| protein serine/threonine phosphatase | |
| protein tyrosine phosphatase | |
| protein tyrosine/serine/threonine phosphatase | |
| phosphoprotein phosphatase | |
| inositol or phosphatidylinositol phosphatase | |
| platelet-derived growth factor receptor binding | |
| lipid binding | |
| lipid phosphatase | |
| phosphoric monoester hydrolase |
| Mus musculus Chromosome position | 19 24.5 cM |
|---|---|
| 19 C1 | |
| 19 |
| Source | Curated |
|---|---|
| GO component | |
| ResNet |
| KEGG pathway | Focal adhesion |
|---|---|
| Inositol phosphate metabolism | |
| Phosphatidylinositol signaling system | |
| Tight junction | |
| Glioma | |
| Melanoma | |
| Endometrial cancer | |
| Prostate cancer | |
| Small cell lung cancer |
| Homo sapiens Chromosome position | 10q23.3 |
|---|
| Danio rerio Chromosome position | LG 12 |
|---|