Protein Ncor2

URN	urn:agi-llid:9612
Total Entities	0
Connectivity	439
Name	Ncor2
Description	nuclear receptor corepressor 2
Notes	This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Ariadne Ontology	Transcription factors

GO Molecular Function	chromatin binding
	protein complex binding
	protein N-terminus binding
	retinoic acid receptor binding
	retinoid X receptor binding
	Notch binding
	ligand-dependent nuclear receptor binding
	glucocorticoid receptor binding
	histone deacetylase binding
	DNA binding
	sequence-specific DNA binding
	RNA polymerase II regulatory region DNA binding
	transcription corepressor activity

GO Cellular Component	nucleoplasm
	nucleolus
	histone deacetylase complex
	nuclear body
	transcriptional repressor complex
	chromatin
	nucleus

GO Biological Process	Notch signaling pathway
	transforming growth factor beta receptor signaling pathway
	negative regulation of transcription, DNA-dependent
	negative regulation of transcription from RNA polymerase II promoter
	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	negative regulation of fat cell differentiation
	white fat cell differentiation
	cellular lipid metabolic process
	transcription, DNA-dependent
	transcription initiation from RNA polymerase II promoter
	cell proliferation in forebrain
	response to organic nitrogen
	response to estradiol stimulus
	forebrain development
	telencephalon development
	in utero embryonic development
	heart morphogenesis
	lactation
	ovulation cycle
	estrous cycle phase
	small molecule metabolic process
	gene expression
	glucose homeostasis

Pathway	Histone Acetylation
	EGFR -> NCOR2 signaling
	Notch -> RBPJ/HES/HEY signaling
	DLL1 Expression Targets
	DLL3 Expression Targets
	DLL4 Expression Targets
	ADAM17 Expression Targets
	JAG1 Expression Targets
	CTGF/NCOR2 Expression Target
	AREG/NCOR2 Expression Targets
	EGF/NCOR2 Expression Target
	FGF1/NCOR2 Expression Target
	FGF2/NCOR2 Expression Targets
	FGF23/NCOR2 Expression Targets
	VEGFA/NCOR2 Expression Target
	FIGF/NCOR2 Expression Target
	NOTCH Expression Targets
	prostate cancer pathway
	prostate cancer pathway

Group	Transcription factors
	Notch signaling pathway
	transforming growth factor beta receptor signaling pathway
	negative regulation of transcription, DNA-dependent
	negative regulation of transcription from RNA polymerase II promoter
	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	negative regulation of fat cell differentiation
	white fat cell differentiation
	cellular lipid metabolic process
	transcription, DNA-dependent
	transcription initiation from RNA polymerase II promoter
	cell proliferation in forebrain
	response to organic nitrogen
	response to estradiol stimulus
	forebrain development
	telencephalon development
	in utero embryonic development
	heart morphogenesis
	lactation
	ovulation cycle
	estrous cycle phase
	small molecule metabolic process
	gene expression
	glucose homeostasis
	chromatin binding
	protein complex binding
	protein N-terminus binding
	retinoic acid receptor binding
	retinoid X receptor binding
	Notch binding
	ligand-dependent nuclear receptor binding
	glucocorticoid receptor binding
	histone deacetylase binding
	DNA binding
	sequence-specific DNA binding
	RNA polymerase II regulatory region DNA binding
	transcription corepressor activity
	nucleoplasm
	nucleolus
	histone deacetylase complex
	nuclear body
	transcriptional repressor complex
	chromatin
	nucleus

MedScan ID	9612

Hugo ID	7673

Human chromosome position	12q24

Alias	SMRT
	TRAC
	CTG26
	SMRTE
	TRAC1
	N-CoR2
	TNRC14
	TRAC-1
	SMAP270
	SMRTE-tau
	nuclear receptor corepressor 2
	CTG repeat protein 26
	T3 receptor-associating factor
	thyroid-, retinoic-acid-receptor-associated corepressor
	silencing mediator for retinoid and thyroid hormone receptors
	N-CoR
	silencing mediator of retinoic acid and thyroid hormone receptor
	silencing mediator of retinoid acid and thyroid hormone receptor
	Silencing mediator of retinoic acid and thyroid hormone receptors
	OTTMUSP00000018650
	Thyroid-, retinoic-acid-receptor-associated co-repressor
	PIR:S60255
	transcription co-repressor SMRT
	OTTMUSP00000018647
	OTTMUSP00000018644
	OTTMUSP00000018646
	FLJ25011
	NCOR2
	CTG26 alternate open reading frame
	nuclear receptor co-repressor 2
	nuclear receptor co-repressor II
	OTTHUMP00000197398
	OTTHUMP00000197399
	OTTHUMP00000197400
	OTTHUMP00000197402
	OTTMUSP00000018645
	LOC51044

OMIM ID	600848

PIR ID	S60255

Swiss-Prot ID	NCOR2_MOUSE
	NCOR2_HUMAN

Cell Localization	Nucleus

Mouse chromosome position	5

Rat chromosome position	12q15

Homologene ID	31370

MGI ID	1337080

RGD ID	1310293

Primary Cell Localization	Nucleus