Protein Ncoa2

URN	urn:agi-llid:10499
Total Entities	0
Connectivity	510
Name	Ncoa2
Description	nuclear receptor coactivator 2
Notes	The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]

Ariadne Ontology	PAS domain
	Secreted proteins

GO Molecular Function	chromatin binding
	protein complex binding
	receptor binding
	thyroid hormone receptor binding
	retinoic acid receptor binding
	retinoid X receptor binding
	ligand-dependent nuclear receptor binding
	nuclear hormone receptor binding
	progesterone receptor binding
	estrogen receptor binding
	glucocorticoid receptor binding
	DNA polymerase binding
	PDZ domain binding
	DNA binding
	histone acetyltransferase activity
	transcription coactivator activity
	ligand-dependent nuclear receptor transcription coactivator activity
	thyroid hormone receptor coactivator activity
	signal transducer activity

GO Cellular Component	nucleoplasm
	postsynaptic density
	microtubule
	cytoplasm
	Golgi apparatus
	rough endoplasmic reticulum
	nucleus
	dendritic spine
	dendrite
	neuronal cell body
	presynaptic active zone

GO Biological Process	positive regulation of glucocorticoid receptor signaling pathway
	signal transduction
	androgen receptor signaling pathway
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of transcription, DNA-dependent
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	cellular lipid metabolic process
	transcription, DNA-dependent
	histone acetylation
	positive regulation of female receptivity
	male gonad development
	cerebellum development
	small molecule metabolic process

Group	PAS domain
	positive regulation of glucocorticoid receptor signaling pathway
	signal transduction
	androgen receptor signaling pathway
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of transcription, DNA-dependent
	negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	cellular lipid metabolic process
	transcription, DNA-dependent
	histone acetylation
	positive regulation of female receptivity
	male gonad development
	cerebellum development
	small molecule metabolic process
	chromatin binding
	protein complex binding
	receptor binding
	thyroid hormone receptor binding
	retinoic acid receptor binding
	retinoid X receptor binding
	ligand-dependent nuclear receptor binding
	nuclear hormone receptor binding
	progesterone receptor binding
	estrogen receptor binding
	glucocorticoid receptor binding
	DNA polymerase binding
	PDZ domain binding
	DNA binding
	histone acetyltransferase activity
	transcription coactivator activity
	ligand-dependent nuclear receptor transcription coactivator activity
	thyroid hormone receptor coactivator activity
	signal transducer activity
	nucleoplasm
	postsynaptic density
	microtubule
	cytoplasm
	Golgi apparatus
	rough endoplasmic reticulum
	nucleus
	dendritic spine
	dendrite
	neuronal cell body
	presynaptic active zone
	Secreted proteins

MedScan ID	10499

Hugo ID	7669

Human chromosome position	8q13.3

Alias	SRC2
	TIF2
	GRIP1
	KAT13C
	NCoA-2
	bHLHe75
	nuclear receptor coactivator 2
	hTIF2
	transcriptional intermediary factor 2
	class E basic helix-loop-helix protein 75
	glucocorticoid receptor-interacting protein-1
	SRC-2
	TIF-2
	GRIP-1
	9530095N19
	D1Ertd433e
	TIF2/GRIP-1
	glucocorticoid receptor interacting protein 1
	glucocorticoid receptor-interacting protein 1
	MGC138808
	NCOA2
	OTTMUSP00000024144
	OTTMUSP00000024153
	N-COA2
	Transcriptional intermediary factor II
	DNA segment, Chr 1, ERATO Doi 433, expressed
	GRIP1/TIF2
	nuclear receptor coactivator II
	Glucocorticoid Receptor (GR) Interacting Protein-1
	glucocorticoid receptor-interacting protein I
	glucocorticoid receptor-interactive protein I
	glucocorticoid receptor-interactive protein-1
	GNB:1853980
	GNB:1877215

OMIM ID	601993

PIR ID	T30193
	T42639

Cell Localization	Nucleus

Mouse chromosome position	1 1.0 cM

Rat chromosome position	5q11

Homologene ID	4768

MGI ID	1276533

RGD ID	620108

Primary Cell Localization	Nucleus