| URN | urn:agi-llid:367 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2814 |
| Name | Ar |
| Description | androgen receptor |
| Notes | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq] |
| Ariadne Ontology | Estrogen-like |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | lipid binding |
|---|---|
| chromatin binding | |
| receptor binding | |
| beta-catenin binding | |
| transcription factor binding | |
| protein domain specific binding | |
| enzyme binding | |
| RNA polymerase II transcription factor binding | |
| androgen receptor binding | |
| POU domain binding | |
| steroid binding | |
| androgen binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| androgen receptor activity | |
| steroid hormone receptor activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| nuclear chromatin | |
| protein complex | |
| plasma membrane | |
| cytoplasm | |
| nucleus | |
| axon | |
| dendrite |
| GO Biological Process | cell proliferation |
|---|---|
| cellular process | |
| cell growth | |
| cell death | |
| epithelial cell differentiation involved in prostate gland development | |
| cell-cell signaling | |
| activation of prostate induction by androgen receptor signaling pathway | |
| positive regulation of insulin-like growth factor receptor signaling pathway | |
| positive regulation of MAPK cascade | |
| positive regulation of intracellular estrogen receptor signaling pathway | |
| signal transduction | |
| intracellular receptor mediated signaling pathway | |
| steroid hormone mediated signaling pathway | |
| androgen receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase III promoter | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of phosphorylation | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of integrin biosynthetic process | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of apoptotic process | |
| positive regulation of integrin biosynthetic process | |
| positive regulation of cell proliferation | |
| regulation of establishment of protein localization to plasma membrane | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| cellular response to steroid hormone stimulus | |
| response to insulin stimulus | |
| regulation of developmental growth | |
| regulation of prostatic bud formation | |
| regulation of catalytic activity | |
| regulation of gene expression | |
| sex differentiation | |
| tertiary branching involved in mammary gland duct morphogenesis | |
| prostate gland growth | |
| prostate gland epithelium morphogenesis | |
| reproductive structure development | |
| male somatic sex determination | |
| male sex differentiation | |
| prostate gland development | |
| male gonad development | |
| male genitalia morphogenesis | |
| organ formation | |
| lateral sprouting involved in mammary gland duct morphogenesis | |
| mammary gland alveolus development | |
| in utero embryonic development | |
| morphogenesis of an epithelial fold | |
| transport | |
| gene expression | |
| protein oligomerization | |
| regulation of systemic arterial blood pressure |
| Pathway | S100P Expression Target |
|---|---|
| TGFB1-ACVRL1 Expression Targets | |
| prostate cancer pathway | |
| androgen signaling pathway | |
| altered androgen signaling pathway | |
| prostate cancer pathway | |
| androgen signaling pathway | |
| altered androgen signaling pathway | |
| prostate cancer pathway |
| Group | Estrogen-like |
|---|---|
| cell proliferation | |
| cellular process | |
| cell growth | |
| cell death | |
| epithelial cell differentiation involved in prostate gland development | |
| cell-cell signaling | |
| activation of prostate induction by androgen receptor signaling pathway | |
| positive regulation of insulin-like growth factor receptor signaling pathway | |
| positive regulation of MAPK cascade | |
| positive regulation of intracellular estrogen receptor signaling pathway | |
| signal transduction | |
| intracellular receptor mediated signaling pathway | |
| steroid hormone mediated signaling pathway | |
| androgen receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase III promoter | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of phosphorylation | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of integrin biosynthetic process | |
| negative regulation of epithelial cell proliferation | |
| negative regulation of apoptotic process | |
| positive regulation of integrin biosynthetic process | |
| positive regulation of cell proliferation | |
| regulation of establishment of protein localization to plasma membrane | |
| transcription, DNA-dependent | |
| transcription initiation from RNA polymerase II promoter | |
| cellular response to steroid hormone stimulus | |
| response to insulin stimulus | |
| regulation of developmental growth | |
| regulation of prostatic bud formation | |
| regulation of catalytic activity | |
| regulation of gene expression | |
| sex differentiation | |
| tertiary branching involved in mammary gland duct morphogenesis | |
| prostate gland growth | |
| prostate gland epithelium morphogenesis | |
| reproductive structure development | |
| male somatic sex determination | |
| male sex differentiation | |
| prostate gland development | |
| male gonad development | |
| male genitalia morphogenesis | |
| organ formation | |
| lateral sprouting involved in mammary gland duct morphogenesis | |
| mammary gland alveolus development | |
| in utero embryonic development | |
| morphogenesis of an epithelial fold | |
| transport | |
| gene expression | |
| protein oligomerization | |
| regulation of systemic arterial blood pressure | |
| lipid binding | |
| chromatin binding | |
| receptor binding | |
| beta-catenin binding | |
| transcription factor binding | |
| protein domain specific binding | |
| enzyme binding | |
| RNA polymerase II transcription factor binding | |
| androgen receptor binding | |
| POU domain binding | |
| steroid binding | |
| androgen binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | |
| androgen receptor activity | |
| steroid hormone receptor activity | |
| nucleoplasm | |
| nuclear chromatin | |
| protein complex | |
| plasma membrane | |
| cytoplasm | |
| nucleus | |
| axon | |
| dendrite | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 367 |
|---|
| Hugo ID | 644 |
|---|
| Human chromosome position | Xq12 |
|---|---|
| Xq11.2-q12 |
| LocusLink ID | 367 |
|---|---|
| 11835 | |
| 24208 |
| Alias | KD |
|---|---|
| AIS | |
| TFM | |
| DHTR | |
| SBMA | |
| HYSP1 | |
| NR3C4 | |
| SMAX1 | |
| HUMARA | |
| RP11-383C12.1 | |
| androgen receptor | |
| dihydrotestosterone receptor | |
| androgen nuclear receptor variant 2 | |
| nuclear receptor subfamily 3 group C member 4 | |
| AW320017 | |
| RP23-405B8.1 | |
| testicular feminization | |
| Andr | |
| androgen receptor (Testicular feminization), same as Tfm | |
| OTTHUMP00000061928 | |
| OTTMUSP00000019597 | |
| testicular feminization gene | |
| testicular feminization protein | |
| androgen receptor (Testicular feminization) | |
| ANDR_HUMAN | |
| hAR | |
| androgen receptors | |
| OTTHUMP00000023450 | |
| Dihydrotestosterone receptors | |
| ANDR_RAT | |
| SMAX I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 313700 |
|---|---|
| 300068 | |
| 313200 | |
| 176807 | |
| 312300 | |
| 300633 |
| Unigene ID | Hs.76704 |
|---|---|
| Mm.39005 | |
| Mm.394224 | |
| Mm.439657 | |
| Rn.9813 | |
| Hs.496240 |
| KEGG ID | hsa:367 |
|---|---|
| mmu:11835 | |
| rno:24208 |
| Swiss-Prot Accession | P10275 |
|---|---|
| F1D8N5 | |
| B1AVE7 | |
| P19091 | |
| P15207 | |
| Q63049 | |
| A2RUN2 | |
| B1AKD7 | |
| Q9UD95 | |
| Q9NUA2 | |
| Q13771 | |
| Q9BZG5 | |
| Q9BZG6 | |
| Q9BZG7 | |
| Q9UN21 |
| GO ID | 0003677 |
|---|---|
| 0070974 | |
| 0001085 | |
| 0005497 | |
| 0004882 | |
| 0050681 | |
| 0008013 | |
| 0003682 | |
| 0019899 | |
| 0004879 | |
| 0005102 | |
| 0043565 | |
| 0003700 | |
| 0008134 | |
| 0044212 | |
| 0008270 | |
| 0060520 | |
| 0030521 | |
| 0008219 | |
| 0016049 | |
| 0008283 | |
| 0007267 | |
| 0060742 | |
| 0010467 | |
| 0001701 | |
| 0030522 | |
| 0060599 | |
| 0048808 | |
| 0008584 | |
| 0019102 | |
| 0060749 | |
| 0060571 | |
| 0043066 | |
| 0050680 | |
| 0045720 | |
| 0048645 | |
| 0043410 | |
| 0051092 | |
| 0008284 | |
| 0043568 | |
| 0045726 | |
| 0033148 | |
| 0042327 | |
| 0045944 | |
| 0045945 | |
| 0045893 | |
| 0030850 | |
| 0060740 | |
| 0060736 | |
| 0051259 | |
| 0050790 | |
| 0048638 | |
| 0090003 | |
| 0060685 | |
| 0032868 | |
| 0007548 | |
| 0007165 | |
| 0060748 | |
| 0006367 | |
| 0006351 | |
| 0006810 | |
| 0030424 | |
| 0005737 | |
| 0030425 | |
| 0000790 | |
| 0005654 | |
| 0005634 | |
| 0043234 | |
| 0008289 | |
| 0046872 | |
| 0019904 | |
| 0005496 | |
| 0003707 | |
| 0009987 | |
| 0046661 | |
| 0010468 | |
| 0003073 | |
| 0006357 | |
| 0006355 | |
| 0048608 | |
| 0043401 | |
| 0005886 | |
| 0071383 | |
| 0010843 | |
| 0004872 | |
| 0016563 | |
| 0010552 | |
| 0045449 | |
| 0006350 | |
| 0046983 | |
| 0005515 |
| PIR ID | A35895 |
|---|---|
| B40494 | |
| A39248 |
| Swiss-Prot ID | ANDR_MOUSE |
|---|---|
| ANDR_RAT | |
| ANDR_HUMAN | |
| B1AVE7_MOUSE | |
| Q9NUA2_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00113217 |
|---|---|
| IPI00207089 | |
| IPI00020070 | |
| IPI00982907 | |
| IPI00333533 | |
| IPI00873382 |
| Mouse chromosome position | X 36.0 cM |
|---|
| Rat chromosome position | Xq22-q32 |
|---|
| Homologene ID | 28 |
|---|
| MGI ID | 88064 |
|---|
| RGD ID | 2147 |
|---|
| Primary Cell Localization | Nucleus |
|---|