| URN | urn:agi-llid:367 |
|---|---|
| Connectivity | 1290 |
| Name | Ar |
| Description | androgen receptor |
| Notes | The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq] |
| Pathway | prostate cancer pathway |
|---|---|
| androgen signaling pathway | |
| altered androgen signaling pathway |
| GO Molecular Function | lipid binding |
|---|---|
| transcription activator activity | |
| transcription factor activity | |
| beta-catenin binding | |
| transcription factor binding | |
| receptor binding | |
| androgen binding | |
| steroid binding | |
| DNA binding | |
| POU domain binding | |
| androgen receptor binding | |
| sequence-specific DNA binding | |
| promoter binding | |
| metal ion binding | |
| zinc ion binding | |
| receptor activity | |
| steroid hormone receptor activity | |
| androgen receptor activity |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus | |
| axon | |
| dendrite |
| GO Biological Process | cell proliferation |
|---|---|
| cellular process | |
| cell death | |
| cell growth | |
| cell-cell signaling | |
| transport | |
| reproductive structure development | |
| mammary gland alveolus development | |
| regulation of developmental growth | |
| prostate gland growth | |
| epithelial cell differentiation involved in prostate gland development | |
| sex differentiation | |
| tertiary branching involved in mammary gland duct morphogenesis | |
| prostate gland epithelium morphogenesis | |
| organ formation | |
| male sex differentiation | |
| prostate gland development | |
| male somatic sex determination | |
| male gonad development | |
| regulation of prostatic bud formation | |
| activation of prostate induction by androgen receptor signaling pathway | |
| morphogenesis of an epithelial fold | |
| lateral sprouting involved in mammary gland duct morphogenesis | |
| in utero embryonic development | |
| signal transduction | |
| positive regulation of MAPKKK cascade | |
| positive regulation of insulin-like growth factor receptor signaling pathway | |
| positive regulation of estrogen receptor signaling pathway | |
| regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of epithelial cell proliferation | |
| transcription | |
| transcription, DNA-dependent | |
| response to insulin stimulus | |
| regulation of gene expression | |
| androgen receptor signaling pathway | |
| regulation of catalytic activity |
| Ariadne Ontology | Estrogen-like |
|---|
| Group | Estrogen-like |
|---|---|
| cell proliferation | |
| cellular process | |
| cell death | |
| cell growth | |
| cell-cell signaling | |
| transport | |
| reproductive structure development | |
| mammary gland alveolus development | |
| regulation of developmental growth | |
| prostate gland growth | |
| epithelial cell differentiation involved in prostate gland development | |
| sex differentiation | |
| tertiary branching involved in mammary gland duct morphogenesis | |
| prostate gland epithelium morphogenesis | |
| organ formation | |
| male sex differentiation | |
| prostate gland development | |
| male somatic sex determination | |
| male gonad development | |
| regulation of prostatic bud formation | |
| activation of prostate induction by androgen receptor signaling pathway | |
| morphogenesis of an epithelial fold | |
| lateral sprouting involved in mammary gland duct morphogenesis | |
| in utero embryonic development | |
| signal transduction | |
| positive regulation of MAPKKK cascade | |
| positive regulation of insulin-like growth factor receptor signaling pathway | |
| positive regulation of estrogen receptor signaling pathway | |
| regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of epithelial cell proliferation | |
| transcription | |
| transcription, DNA-dependent | |
| response to insulin stimulus | |
| regulation of gene expression | |
| androgen receptor signaling pathway | |
| regulation of catalytic activity | |
| lipid binding | |
| transcription activator activity | |
| transcription factor activity | |
| beta-catenin binding | |
| transcription factor binding | |
| receptor binding | |
| androgen binding | |
| steroid binding | |
| DNA binding | |
| POU domain binding | |
| androgen receptor binding | |
| sequence-specific DNA binding | |
| promoter binding | |
| metal ion binding | |
| zinc ion binding | |
| receptor activity | |
| steroid hormone receptor activity | |
| androgen receptor activity | |
| cytoplasm | |
| nucleus | |
| axon | |
| dendrite |
| MedScan ID | 367 |
|---|
| Hugo ID | 644 |
|---|
| Human chromosome position | Xq11.2-q12 |
|---|
| LocusLink ID | 367 |
|---|---|
| 11835 | |
| 24208 |
| Alias | KD |
|---|---|
| AIS | |
| TFM | |
| DHTR | |
| SBMA | |
| HYSP1 | |
| NR3C4 | |
| SMAX1 | |
| HUMARA | |
| RP11-383C12.1 | |
| androgen receptor | |
| dihydrotestosterone receptor | |
| nuclear receptor subfamily 3 group C member 4 | |
| AW320017 | |
| RP23-405B8.1 | |
| OTTMUSP00000019597 | |
| testicular feminization | |
| Andr | |
| androgen receptor (Testicular feminization), same as Tfm | |
| ANDR_HUMAN | |
| ANDR_RAT | |
| androgen receptor (Testicular feminization) | |
| androgen receptors | |
| Dihydrotestosterone receptors | |
| hAR | |
| OTTHUMP00000023450 | |
| OTTHUMP00000061928 | |
| SMAX I | |
| testicular feminization gene | |
| testicular feminization protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 313700 |
|---|---|
| 300068 | |
| 312300 | |
| 300633 | |
| 176807 | |
| 313200 |
| Mouse chromosome position | X 36.0 cM |
|---|
| GO ID | 0003677 |
|---|---|
| 0070974 | |
| 0005497 | |
| 0004882 | |
| 0008013 | |
| 0046872 | |
| 0010843 | |
| 0004872 | |
| 0005102 | |
| 0016563 | |
| 0003700 | |
| 0008134 | |
| 0008270 | |
| 0060520 | |
| 0008219 | |
| 0016049 | |
| 0008283 | |
| 0007267 | |
| 0060742 | |
| 0001701 | |
| 0060599 | |
| 0008584 | |
| 0046661 | |
| 0019102 | |
| 0060749 | |
| 0060571 | |
| 0050680 | |
| 0048645 | |
| 0043410 | |
| 0033148 | |
| 0010552 | |
| 0043568 | |
| 0030850 | |
| 0060740 | |
| 0060736 | |
| 0050790 | |
| 0048638 | |
| 0060685 | |
| 0032868 | |
| 0007548 | |
| 0007165 | |
| 0060748 | |
| 0006351 | |
| 0006810 | |
| 0030424 | |
| 0005737 | |
| 0030425 | |
| 0005634 | |
| 0008289 | |
| 0043565 | |
| 0005496 | |
| 0003707 | |
| 0030521 | |
| 0009987 | |
| 0045944 | |
| 0010468 | |
| 0045449 | |
| 0006357 | |
| 0006355 | |
| 0048608 | |
| 0006350 | |
| 0050681 | |
| 0046983 | |
| 0005515 |
| Rat chromosome position | Xq22-q32 |
|---|
| Swiss-Prot Accession | P10275 |
|---|---|
| Q9NUA2 | |
| Q13771 | |
| Q9BZG5 | |
| Q9BZG6 | |
| Q9BZG7 | |
| Q9UN21 | |
| B1AVE7 | |
| P19091 | |
| P15207 | |
| Q63049 | |
| A2RUN2 | |
| B1AKD7 | |
| Q9UD95 |
| PIR ID | A35895 |
|---|---|
| B40494 | |
| A39248 |
| Unigene ID | Hs.496240 |
|---|---|
| Mm.39005 | |
| Mm.394224 | |
| Mm.439657 | |
| Rn.9813 |
| KEGG ID | hsa:367 |
|---|---|
| mmu:11835 | |
| rno:24208 |
| Swiss-Prot ID | ANDR_MOUSE |
|---|---|
| ANDR_RAT | |
| ANDR_HUMAN | |
| B1AVE7_MOUSE | |
| Q9NUA2_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00113217 |
|---|---|
| IPI00207089 | |
| IPI00020070 | |
| IPI00333533 | |
| IPI00873382 |
| Homologene ID | 28 |
|---|
| RGD ID | 2147 |
|---|
| MGI ID | 88064 |
|---|