Elsevier Inc. upregulated target translation downregulated target translation Prostatic Neoplasms altered p53 signaling pathway ---> altered expression of target genes gene fusion events ---> Prostatic Neoplasms androgen independent Ar activity ---> altered expression of target genes androgen independent Ar activity altered androgen signaling pathway ---> androgen independent Ar activity gene fusion events Tp53 altered p53 signaling pathway donwregulated miRNA altered expression of target genes upergulated miRNA Ncor2 Ncoa2 Ar altered androgen signaling pathway donwregulated miRNA ---> upregulated target translation potential PC miRNA ---> Prostatic Neoplasms upergulated miRNA ---> downregulated target translation potential PC miRNA Pten Pik3ca altered androgen signaling pathway ---> increased Ar activity increased Ar activity altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes increased Ar activity ---> altered expression of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway altered regulation of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered regulation of target genes