| Hugo ID | 6855 |
|---|---|
| Name | Map3k3 |
| Description | mitogen activated protein kinase kinase kinase 3 (predicted) |
| Notes | This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Owner | Public |
| URN | urn:agi-llid:4215 |
| Connectivity | 166 |
| Source | Curated |
|---|
| LocusLink ID | 4215 |
|---|---|
| 26406 | |
| 303604 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602539 |
|---|
| Alias | MEKK3 |
|---|---|
| MAPKKK3 | |
| mitogen-activated protein kinase kinase kinase 3 | |
| MAP/ERK kinase kinase 3 | |
| MAPK/ERK kinase kinase 3 | |
| AW548911 | |
| KIAA4031 | |
| mKIAA4031 | |
| mitogen activated protein kinase kinase kinase 3 | |
| MEK kinase 3 | |
| mitogen activated protein kinase kinase kinase 3 (predicted) |
| GO ID | 0005524 |
|---|---|
| 0004709 | |
| 0000287 | |
| 0000166 | |
| 0005515 | |
| 0004674 | |
| 0004871 | |
| 0016740 | |
| 0000165 | |
| 0043123 | |
| 0046777 | |
| 0006468 | |
| 0016301 | |
| 0046872 | |
| 0004672 | |
| 0004713 | |
| 0007243 |
| Swiss-Prot Accession | Q5BKZ6 |
|---|---|
| Q7Z4E6 | |
| Q8N3I9 | |
| Q96FS8 | |
| Q96HN9 | |
| Q99759 | |
| Q5DTS0 | |
| Q61084 |
| Unigene ID | Hs.29282 |
|---|---|
| Mm.27041 |
| RGD ID | 1304575 |
|---|
| MGI ID | 1346874 |
|---|
| Pathway | Jnk-mapk |
|---|---|
| p38 MAPK | |
| p40 MAPK | |
| CD28 -> NF-kB signaling pathway | |
| p38 MAPK signaling pathway | |
| Erk5 MAPK signaling pathway |
| Group | Kinases |
|---|---|
| protein kinase cascade | |
| MAPKKK cascade | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| signal transducer activity | |
| nucleotide binding | |
| protein binding | |
| metal ion binding | |
| magnesium ion binding | |
| ATP binding | |
| transferase activity | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein-tyrosine kinase activity | |
| MAP kinase kinase kinase activity |