| URN | urn:agi-llid:79412 |
|---|---|
| Connectivity | 17 |
| Name | Kremen2 |
| Description | kringle containing transmembrane protein 2 |
| Notes | This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. |
| Pathway | canonical Wnt signaling pathway |
|---|---|
| altered canonical Wnt signaling pathway | |
| canonical Wnt signaling pathway | |
| altered canonical Wnt signaling pathway | |
| Wnt signaling, canonical pathway | |
| altered Wnt signaling, canonical pathway |
| GO Cellular Component | membrane |
|---|---|
| integral to membrane |
| GO Biological Process | Wnt receptor signaling pathway |
|---|
| Ariadne Ontology | DKK |
|---|
| Group | DKK |
|---|---|
| Wnt receptor signaling pathway | |
| membrane | |
| integral to membrane |
| MedScan ID | 79412 |
|---|
| Hugo ID | 18797 |
|---|
| Human chromosome position | 16p13.3 |
|---|
| LocusLink ID | 79412 |
|---|---|
| 73016 | |
| 287102 |
| Alias | KRM2 |
|---|---|
| MGC10791 | |
| MGC16709 | |
| kremen protein 2 | |
| dickkopf receptor 2 | |
| kringle domain-containing transmembrane protein 2 | |
| kringle-containing protein marking the eye and the nose | |
| 2900054E04Rik | |
| 2900054E04 | |
| Kremen2 | |
| kringle containing transmembrane protein 2 | |
| kringle containing transmembrane protein II | |
| kringle-containing transmembrane protein 2 isoform a | |
| kringle-containing transmembrane protein 2 isoform b | |
| kringle-containing transmembrane protein 2 isoform c | |
| kringle-containing transmembrane protein 2 isoform d | |
| LOC240049 | |
| LOC96212 | |
| kringle-containing transmembrane protein 2 | |
| kringle-containing transmembrane protein 2 isoform a precursor | |
| kringle-containing transmembrane protein 2 isoform c precursor | |
| kringle-containing transmembrane protein 2 isoform d precursor | |
| kringle-containing transmembrane protein 2 isoform b precursor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 609899 |
|---|
| Mouse chromosome position | 17 |
|---|---|
| 17 A3.3 |
| GO ID | 0016055 |
|---|---|
| 0016021 | |
| 0016020 | |
| 0005515 |
| Rat chromosome position | 10q12 |
|---|
| Swiss-Prot Accession | Q8NCW0 |
|---|---|
| Q53F67 | |
| Q8K1S7 | |
| Q8N2J4 | |
| Q8NCW1 | |
| Q96GL8 | |
| Q9BTP9 | |
| Q0VBR6 |
| Unigene ID | Hs.661128 |
|---|---|
| Mm.221319 | |
| Rn.218464 |
| KEGG ID | hsa:79412 |
|---|---|
| mmu:73016 | |
| rno:287102 |
| Swiss-Prot ID | KREM2_HUMAN |
|---|---|
| KREM2_MOUSE | |
| Q0VBR6_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Extracellular |
| IPI ID | IPI00001574 |
|---|---|
| IPI00101504 | |
| IPI00168475 | |
| IPI00168476 | |
| IPI00321951 | |
| IPI00645005 | |
| IPI00870199 |
| Homologene ID | 65132 |
|---|
| RGD ID | 1310795 |
|---|
| MGI ID | 1920266 |
|---|