| URN | urn:agi-llid:26234 |
|---|---|
| Total Entities | 0 |
| Connectivity | 67 |
| Name | Fbxl5 |
| Description | F-box and leucine-rich repeat protein 5 |
| Notes | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010] |
| GO Molecular Function | ubiquitin-protein ligase activity |
|---|---|
| metal ion binding | |
| iron ion binding |
| GO Cellular Component | ubiquitin ligase complex |
|---|---|
| SCF ubiquitin ligase complex | |
| cytoplasm | |
| perinuclear region of cytoplasm |
| GO Biological Process | protein ubiquitination |
|---|---|
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | |
| iron ion homeostasis |
| Pathway | iron homeostasis pathway |
|---|
| Group | Ubiquitin-dependent protein degradation |
|---|---|
| ubiquitin-protein ligase activity | |
| protein ubiquitination | |
| SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | |
| iron ion homeostasis | |
| metal ion binding | |
| iron ion binding | |
| ubiquitin ligase complex | |
| SCF ubiquitin ligase complex | |
| cytoplasm | |
| perinuclear region of cytoplasm |
| LocusLink ID | 26234 |
|---|---|
| 242960 | |
| 305424 |
| Cell Localization | Cytoplasm |
|---|---|
| Perinuclear region |
| GO ID | 0005506 |
|---|---|
| 0004842 | |
| 0031146 | |
| 0055072 | |
| 0016567 | |
| 0019005 | |
| 0048471 | |
| 0000151 | |
| 0046872 | |
| 0005737 |
| Alias | FBL4 |
|---|---|
| FBL5 | |
| FLR1 | |
| F-box/LRR-repeat protein 5 | |
| F-box protein FBL5 | |
| p45SKP2-like protein | |
| F-box protein FBL4/FBL5 | |
| Fir4 | |
| OTTMUSP00000036973 | |
| OTTMUSP00000036971 | |
| OTTMUSP00000036970 | |
| LOC242960 | |
| Fbxl5 | |
| F-box and leucine-rich repeat protein V | |
| F-box and leucine-rich repeat protein 5 | |
| FLR I |
| Mouse chromosome position | 5 |
|---|
| OMIM ID | 605655 |
|---|
| Rat chromosome position | 14q21 |
|---|
| Hugo ID | 13602 |
|---|
| Human chromosome position | 4p15.32 |
|---|
| Swiss-Prot Accession | Q9UKA1 |
|---|---|
| Q8C2S5 | |
| D3ZA08 | |
| A8MSK4 | |
| B4DIB5 | |
| Q4W5A8 | |
| Q8NHP3 | |
| Q9NXN2 | |
| Q9P0I0 | |
| Q9P0X5 | |
| Q9UJT7 | |
| Q9UKC8 | |
| Q14CG1 | |
| Q3TAK6 | |
| Q3TWC9 | |
| Q3UC66 | |
| Q80XI5 | |
| Q8BGF5 | |
| Q8BNL3 | |
| Q8C3Q8 |
| Unigene ID | Hs.643433 |
|---|---|
| Hs.714386 | |
| Mm.25794 | |
| Rn.8259 |
| KEGG ID | hsa:26234 |
|---|---|
| mmu:242960 | |
| rno:305424 |
| Swiss-Prot ID | FBXL5_HUMAN |
|---|---|
| FBXL5_MOUSE |
| Ensembl ID | ENSG00000118564 |
|---|---|
| ENSP00000408679 | |
| ENST00000412094 | |
| ENSP00000344866 | |
| ENST00000341285 | |
| ENSP00000425472 | |
| ENST00000513163 | |
| ENSP00000371795 | |
| ENST00000382358 | |
| ENSMUSG00000039753 | |
| ENSMUSP00000045792 | |
| ENSMUST00000047857 | |
| ENSMUSP00000112444 | |
| ENSMUST00000121736 | |
| ENSRNOG00000005261 | |
| ENSRNOP00000062042 | |
| ENSRNOT00000064636 |
| Homologene ID | 8129 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2152883 |
|---|
| RGD ID | 1306887 |
|---|
| MedScan ID | 26234 |
|---|