| URN | urn:agi-llid:7018 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2065 |
| Name | Tf |
| Description | transferrin |
| Notes | This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009] |
| GO Molecular Function | ferric iron transmembrane transporter activity |
|---|---|
| ubiquitin protein ligase binding | |
| GTP binding | |
| metal ion binding | |
| ferric iron binding |
| GO Cellular Component | extracellular region |
|---|---|
| coated pit | |
| apical plasma membrane | |
| basal plasma membrane | |
| vesicle coat | |
| endosome membrane | |
| secretory granule lumen | |
| basal part of cell | |
| dense body | |
| perinuclear region of cytoplasm | |
| endosome | |
| mitochondrion | |
| recycling endosome | |
| late endosome | |
| early endosome | |
| cytoplasmic membrane-bounded vesicle | |
| endocytic vesicle | |
| basement membrane | |
| extracellular space |
| GO Biological Process | osteoclast differentiation |
|---|---|
| ERK1 and ERK2 cascade | |
| activation of JUN kinase activity | |
| positive regulation of bone resorption | |
| positive regulation of myelination | |
| blood coagulation | |
| platelet activation | |
| positive regulation of oligodendrocyte progenitor proliferation | |
| transmembrane transport | |
| actin filament organization | |
| SMAD protein signal transduction | |
| small GTPase mediated signal transduction | |
| platelet degranulation | |
| iron ion transmembrane transport | |
| cellular iron ion homeostasis | |
| positive regulation of cell motility | |
| apoptotic process | |
| ion transport | |
| iron ion transport | |
| ferric iron transport | |
| transferrin transport | |
| cellular response to cAMP | |
| response to lead ion | |
| cellular response to follicle-stimulating hormone stimulus | |
| response to organic cyclic compound | |
| response to hypoxia | |
| acute-phase response | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of phosphorylation | |
| transport | |
| iron ion homeostasis |
| Pathway | Endosomal Recycling |
|---|---|
| Transcytosis | |
| Traffic and Degradation of Extracellular Amyloid beta in Alzheimer's Disease | |
| Dronabinol/Anandamide Expression Targets | |
| NRG1/AP-1/ATF Expression Targets | |
| NRG1/EP300/ETS/ETV/SP1 Expression Targets | |
| NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| Serotonin/Gs Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| iron homeostasis pathway |
| Group | Me++ homeostasis |
|---|---|
| osteoclast differentiation | |
| ERK1 and ERK2 cascade | |
| activation of JUN kinase activity | |
| positive regulation of bone resorption | |
| positive regulation of myelination | |
| blood coagulation | |
| platelet activation | |
| positive regulation of oligodendrocyte progenitor proliferation | |
| transmembrane transport | |
| actin filament organization | |
| SMAD protein signal transduction | |
| small GTPase mediated signal transduction | |
| platelet degranulation | |
| iron ion transmembrane transport | |
| ferric iron transmembrane transporter activity | |
| cellular iron ion homeostasis | |
| positive regulation of cell motility | |
| apoptotic process | |
| ion transport | |
| iron ion transport | |
| ferric iron transport | |
| transferrin transport | |
| cellular response to cAMP | |
| response to lead ion | |
| cellular response to follicle-stimulating hormone stimulus | |
| response to organic cyclic compound | |
| response to hypoxia | |
| acute-phase response | |
| positive regulation of transcription, DNA-templated | |
| positive regulation of phosphorylation | |
| transport | |
| iron ion homeostasis | |
| ubiquitin protein ligase binding | |
| GTP binding | |
| metal ion binding | |
| ferric iron binding | |
| extracellular region | |
| coated pit | |
| apical plasma membrane | |
| basal plasma membrane | |
| vesicle coat | |
| endosome membrane | |
| secretory granule lumen | |
| basal part of cell | |
| dense body | |
| perinuclear region of cytoplasm | |
| endosome | |
| mitochondrion | |
| recycling endosome | |
| late endosome | |
| early endosome | |
| cytoplasmic membrane-bounded vesicle | |
| endocytic vesicle | |
| basement membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 7018 |
|---|---|
| 22041 | |
| 24825 |
| Cell Localization | Plasma membrane |
|---|---|
| Secreted |
| GO ID | 0008199 |
|---|---|
| 0031625 | |
| 0007596 | |
| 0006879 | |
| 0030168 | |
| 0002576 | |
| 0033572 | |
| 0055085 | |
| 0016324 | |
| 0045178 | |
| 0009925 | |
| 0005905 | |
| 0016023 | |
| 0005769 | |
| 0030139 | |
| 0010008 | |
| 0005576 | |
| 0005770 | |
| 0005739 | |
| 0048471 | |
| 0055037 | |
| 0034774 | |
| 0015091 | |
| 0046872 | |
| 0070371 | |
| 0060395 | |
| 0007015 | |
| 0007257 | |
| 0015682 | |
| 0006811 | |
| 0055072 | |
| 0034755 | |
| 0006826 | |
| 0030316 | |
| 0045780 | |
| 2000147 | |
| 0031643 | |
| 0070447 | |
| 0042327 | |
| 0045893 | |
| 0006810 | |
| 0005604 | |
| 0097433 | |
| 0005768 | |
| 0005615 | |
| 0030120 | |
| 0005525 | |
| 0006953 | |
| 0006915 | |
| 0071320 | |
| 0071372 | |
| 0001666 | |
| 0010288 | |
| 0014070 | |
| 0007264 |
| Alias | TFQTL1 |
|---|---|
| PRO1557 | |
| PRO2086 | |
| PRO1400 | |
| serotransferrin | |
| siderophilin | |
| beta-1 metal-binding globulin | |
| HP | |
| Tf | |
| Tfn | |
| hpx | |
| Cd176 | |
| AI266983 | |
| hypotransferrinemia with hemochromatosis | |
| Trf | |
| liver regeneration-related protein LRRG03 | |
| transferrin | |
| Siderophilin, iron-saturated | |
| transferrins | |
| TRFE | |
| TRFE_HUMAN | |
| OTTMUSP00000029709 | |
| transferrin bound iron | |
| iron transferrin complex | |
| ferric transferrin | |
| apo-Transferrin human | |
| OTTMUSP00000029708 | |
| transferrinemia | |
| Beta-1-metal binding globulin | |
| DKFZp781D0156 | |
| Holotransferrin | |
| Holo-Transferrin | |
| hypoemia with hemochromatosis gene | |
| hypoemia with hemochromatosis protein | |
| hypotransferrinemia with hemochromatosis gene | |
| hypotransferrinemia with hemochromatosis protein | |
| MGC102653 | |
| MGC93500 | |
| holo-Transferrin bovine | |
| 1300017J02 |
| Mouse chromosome position | 9 55.03 cM |
|---|
| OMIM ID | 190000 |
|---|---|
| 209300 |
| Rat chromosome position | 8q32 |
|---|
| Hugo ID | 11740 |
|---|
| Human chromosome position | 3q22.1 |
|---|
| Swiss-Prot Accession | A0PJA6 |
|---|---|
| P02787 | |
| Q06AH7 | |
| J3KN47 | |
| Q921I1 | |
| P12346 | |
| O43890 | |
| Q1HBA5 | |
| Q9NQB8 | |
| Q9UHV0 | |
| Q63602 | |
| Q64628 | |
| Q64630 | |
| Q7TNX0 | |
| O35421 | |
| Q3UBW7 | |
| Q58E69 | |
| Q61803 | |
| Q62357 | |
| Q62358 | |
| Q62359 | |
| Q63915 | |
| Q64515 | |
| Q8VII5 | |
| Q922C0 |
| PIR ID | A20981 |
|---|---|
| S49163 | |
| A28446 |
| Unigene ID | Hs.518267 |
|---|---|
| Mm.37214 | |
| Rn.91296 |
| KEGG ID | hsa:7018 |
|---|---|
| mmu:22041 | |
| rno:24825 |
| Swiss-Prot ID | TRFE_HUMAN |
|---|---|
| TRFE_RAT | |
| TRFE_MOUSE |
| Ensembl ID | ENSG00000091513 |
|---|---|
| ENSP00000385834 | |
| ENST00000402696 | |
| ENSP00000264998 | |
| ENST00000264998 | |
| ENSMUSG00000032554 | |
| ENSMUSP00000035158 | |
| ENSMUST00000035158 | |
| ENSRNOG00000030625 | |
| ENSRNOP00000045637 | |
| ENSRNOT00000045628 |
| Homologene ID | 68153 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98821 |
|---|
| RGD ID | 3845 |
|---|
| MedScan ID | 7018 |
|---|