| URN | urn:agi-llid:4891 |
|---|---|
| Total Entities | 0 |
| Connectivity | 387 |
| Name | Slc11a2 |
| Description | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 |
| Notes | This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010] |
| GO Molecular Function | iron ion transmembrane transporter activity |
|---|---|
| ferrous iron transmembrane transporter activity | |
| inorganic cation transmembrane transporter activity | |
| solute:hydrogen symporter activity | |
| lead ion transmembrane transporter activity | |
| zinc ion transmembrane transporter activity | |
| cadmium ion transmembrane transporter activity | |
| calcium ion transmembrane transporter activity | |
| hydrogen ion transmembrane transporter activity | |
| nickel cation transmembrane transporter activity | |
| vanadium ion transmembrane transporter activity | |
| copper ion transmembrane transporter activity | |
| chromium ion transmembrane transporter activity | |
| cobalt ion transmembrane transporter activity | |
| manganese ion transmembrane transporter activity | |
| transporter activity | |
| zinc ion binding | |
| iron ion binding | |
| nickel cation binding | |
| copper ion binding | |
| cobalt ion binding | |
| cadmium ion binding | |
| manganese ion binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| integral component of plasma membrane | |
| apical plasma membrane | |
| lysosomal membrane | |
| late endosome membrane | |
| paraferritin complex | |
| endomembrane system | |
| basal part of cell | |
| cell surface | |
| plasma membrane | |
| apical part of cell | |
| cytoplasm | |
| vacuole | |
| perinuclear region of cytoplasm | |
| endosome | |
| cytoplasmic vesicle | |
| lysosome | |
| recycling endosome | |
| late endosome | |
| early endosome | |
| trans-Golgi network | |
| nucleus | |
| brush border |
| GO Biological Process | erythrocyte development |
|---|---|
| heme biosynthetic process | |
| multicellular organismal iron ion homeostasis | |
| learning or memory | |
| dendrite morphogenesis | |
| transmembrane transport | |
| manganese ion transmembrane transport | |
| cadmium ion transmembrane transport | |
| zinc ion transmembrane transport | |
| copper ion transmembrane transport | |
| iron ion transmembrane transport | |
| nickel cation transmembrane transport | |
| ferrous iron import | |
| cellular iron ion homeostasis | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| ion transport | |
| transition metal ion transport | |
| lead ion transport | |
| copper ion transport | |
| iron ion transport | |
| manganese ion transport | |
| nickel cation transport | |
| vanadium ion transport | |
| cobalt ion transport | |
| ferrous iron transport | |
| proton transport | |
| response to lead ion | |
| response to iron ion | |
| response to cadmium ion | |
| response to manganese ion | |
| cellular response to iron ion | |
| detection of oxygen | |
| cellular response to oxidative stress | |
| cellular response to tumor necrosis factor | |
| cellular response to hypoxia | |
| response to hypoxia | |
| porphyrin-containing compound biosynthetic process | |
| porphyrin-containing compound metabolic process | |
| transport | |
| iron ion homeostasis |
| Pathway | iron homeostasis pathway |
|---|
| Group | Me++ homeostasis |
|---|---|
| erythrocyte development | |
| heme biosynthetic process | |
| multicellular organismal iron ion homeostasis | |
| learning or memory | |
| dendrite morphogenesis | |
| transmembrane transport | |
| manganese ion transmembrane transport | |
| cadmium ion transmembrane transport | |
| zinc ion transmembrane transport | |
| copper ion transmembrane transport | |
| iron ion transmembrane transport | |
| nickel cation transmembrane transport | |
| ferrous iron import | |
| iron ion transmembrane transporter activity | |
| ferrous iron transmembrane transporter activity | |
| inorganic cation transmembrane transporter activity | |
| solute:hydrogen symporter activity | |
| lead ion transmembrane transporter activity | |
| zinc ion transmembrane transporter activity | |
| cadmium ion transmembrane transporter activity | |
| calcium ion transmembrane transporter activity | |
| hydrogen ion transmembrane transporter activity | |
| nickel cation transmembrane transporter activity | |
| vanadium ion transmembrane transporter activity | |
| copper ion transmembrane transporter activity | |
| chromium ion transmembrane transporter activity | |
| cobalt ion transmembrane transporter activity | |
| manganese ion transmembrane transporter activity | |
| cellular iron ion homeostasis | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| ion transport | |
| transition metal ion transport | |
| lead ion transport | |
| copper ion transport | |
| iron ion transport | |
| manganese ion transport | |
| nickel cation transport | |
| vanadium ion transport | |
| cobalt ion transport | |
| ferrous iron transport | |
| proton transport | |
| response to lead ion | |
| response to iron ion | |
| response to cadmium ion | |
| response to manganese ion | |
| cellular response to iron ion | |
| detection of oxygen | |
| cellular response to oxidative stress | |
| cellular response to tumor necrosis factor | |
| cellular response to hypoxia | |
| response to hypoxia | |
| porphyrin-containing compound biosynthetic process | |
| porphyrin-containing compound metabolic process | |
| transport | |
| transporter activity | |
| iron ion homeostasis | |
| zinc ion binding | |
| iron ion binding | |
| nickel cation binding | |
| copper ion binding | |
| cobalt ion binding | |
| cadmium ion binding | |
| manganese ion binding | |
| membrane | |
| integral component of membrane | |
| integral component of plasma membrane | |
| apical plasma membrane | |
| lysosomal membrane | |
| late endosome membrane | |
| paraferritin complex | |
| endomembrane system | |
| basal part of cell | |
| cell surface | |
| plasma membrane | |
| apical part of cell | |
| cytoplasm | |
| vacuole | |
| perinuclear region of cytoplasm | |
| endosome | |
| cytoplasmic vesicle | |
| lysosome | |
| recycling endosome | |
| late endosome | |
| early endosome | |
| trans-Golgi network | |
| nucleus | |
| brush border | |
| Biofluids assayable substances |
| LocusLink ID | 4891 |
|---|---|
| 18174 | |
| 25715 |
| Cell Localization | Plasma membrane |
|---|---|
| Endosome membrane |
| GO ID | 0015086 |
|---|---|
| 0015085 | |
| 0070835 | |
| 0015087 | |
| 0005375 | |
| 0015093 | |
| 0015078 | |
| 0022890 | |
| 0015094 | |
| 0005384 | |
| 0015099 | |
| 0015295 | |
| 0015100 | |
| 0005385 | |
| 0006919 | |
| 0070574 | |
| 0006879 | |
| 0034599 | |
| 0006824 | |
| 0035434 | |
| 0006825 | |
| 0048813 | |
| 0003032 | |
| 0048821 | |
| 0070627 | |
| 0015684 | |
| 0006783 | |
| 0015692 | |
| 0007611 | |
| 0071421 | |
| 0006828 | |
| 0060586 | |
| 0035444 | |
| 0015675 | |
| 0001666 | |
| 0010039 | |
| 0055085 | |
| 0015676 | |
| 0071577 | |
| 0045177 | |
| 0016324 | |
| 0045178 | |
| 0005903 | |
| 0009986 | |
| 0005737 | |
| 0031410 | |
| 0005769 | |
| 0012505 | |
| 0005887 | |
| 0005770 | |
| 0031902 | |
| 0005765 | |
| 0005764 | |
| 0005634 | |
| 0070826 | |
| 0048471 | |
| 0005886 | |
| 0055037 | |
| 0005802 | |
| 0005773 | |
| 0046870 | |
| 0050897 | |
| 0005507 | |
| 0005506 | |
| 0005381 | |
| 0030145 | |
| 0016151 | |
| 0005215 | |
| 0008270 | |
| 0006811 | |
| 0055072 | |
| 0034755 | |
| 0006826 | |
| 0006779 | |
| 0006778 | |
| 0015992 | |
| 0010042 | |
| 0000041 | |
| 0006810 | |
| 0005768 | |
| 0016021 | |
| 0016020 | |
| 0071456 | |
| 0071281 | |
| 0071356 | |
| 0046686 | |
| 0010288 |
| Alias | DCT1 |
|---|---|
| DMT1 | |
| NRAMP2 | |
| OK/SW-cl.20 | |
| natural resistance-associated macrophage protein 2 | |
| DMT-1 | |
| NRAMP 2 | |
| divalent cation transporter 1 | |
| solute carrier family 11 member 2 | |
| solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | |
| mk | |
| van | |
| divalent metal transporter 1 | |
| microcytic anemia, viable anaemia | |
| Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2) | |
| microcytic anemia protein | |
| DCT I | |
| solute carrier family 11 member II | |
| iron transporter protein DMT1 | |
| divalent metal ion transporter 1 | |
| SLC11A2 | |
| solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | |
| microcytic anemia gene | |
| microcytic anemia, viable anaemia locus | |
| OTTMUSP00000044816 | |
| solute carrier family 11 member A2 | |
| natural resistance-associated macrophage protein II | |
| FLJ37416 | |
| divalent metal transporter I |
| Mouse chromosome position | 15 56.29 cM |
|---|
| OMIM ID | 600523 |
|---|---|
| 206100 |
| Rat chromosome position | 7q36 |
|---|
| Hugo ID | 10908 |
|---|
| Human chromosome position | 12q13 |
|---|
| Swiss-Prot Accession | P49281 |
|---|---|
| P49282 | |
| O54902 | |
| O35172 | |
| B3KT08 | |
| B4DK84 | |
| F5H741 | |
| O43288 | |
| O60932 | |
| O94801 | |
| Q498Z5 | |
| Q8IUD7 | |
| Q96J35 | |
| O54903 | |
| Q3UFV5 | |
| Q8BJL2 | |
| Q8BWV3 | |
| Q8CFA0 | |
| Q8VCU6 |
| PIR ID | I57022 |
|---|---|
| A56852 |
| Unigene ID | Hs.505545 |
|---|---|
| Mm.234608 | |
| Rn.11418 |
| KEGG ID | hsa:4891 |
|---|---|
| mmu:18174 | |
| rno:25715 |
| Swiss-Prot ID | NRAM2_RAT |
|---|---|
| NRAM2_HUMAN | |
| NRAM2_MOUSE |
| Ensembl ID | ENSG00000110911 |
|---|---|
| ENSP00000262052 | |
| ENST00000262052 | |
| ENSP00000378364 | |
| ENST00000394904 | |
| ENSP00000262051 | |
| ENST00000262051 | |
| ENSP00000446769 | |
| ENST00000547198 | |
| ENSMUSG00000023030 | |
| ENSMUSP00000116463 | |
| ENSMUST00000138843 | |
| ENSMUSP00000023774 | |
| ENSMUST00000023774 | |
| ENSRNOG00000019550 | |
| ENSRNOP00000026531 | |
| ENSRNOT00000026531 |
| Homologene ID | 55471 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1345279 |
|---|
| RGD ID | 3684 |
|---|
| MedScan ID | 4891 |
|---|