| URN | urn:agi-llid:1356 |
|---|---|
| Total Entities | 0 |
| Connectivity | 853 |
| Name | Cp |
| Description | ceruloplasmin (ferroxidase) |
| Notes | The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| ferroxidase activity | |
| chaperone binding | |
| metal ion binding | |
| copper ion binding |
| GO Cellular Component | extracellular region |
|---|---|
| anchored component of plasma membrane | |
| lysosomal membrane | |
| extracellular space |
| GO Biological Process | oxidation-reduction process |
|---|---|
| lung development | |
| liver development | |
| aging | |
| transmembrane transport | |
| plasma membrane copper ion transport | |
| cellular iron ion homeostasis | |
| ion transport | |
| copper ion transport | |
| response to nutrient | |
| response to copper ion | |
| transport |
| Pathway | Metals and Amyloid beta Toxicity |
|---|---|
| iron homeostasis pathway |
| Group | Me++ homeostasis |
|---|---|
| Tetrapyrroles biosynthesis | |
| oxidation-reduction process | |
| oxidoreductase activity | |
| ferroxidase activity | |
| lung development | |
| liver development | |
| aging | |
| transmembrane transport | |
| plasma membrane copper ion transport | |
| cellular iron ion homeostasis | |
| ion transport | |
| copper ion transport | |
| response to nutrient | |
| response to copper ion | |
| transport | |
| chaperone binding | |
| metal ion binding | |
| copper ion binding | |
| extracellular region | |
| anchored component of plasma membrane | |
| lysosomal membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 1356 |
|---|---|
| 12870 | |
| 24268 |
| Cell Localization | Plasma membrane |
|---|---|
| Cytoplasm | |
| Secreted |
| GO ID | 0051087 |
|---|---|
| 0005507 | |
| 0004322 | |
| 0006879 | |
| 0006825 | |
| 0055085 | |
| 0005576 | |
| 0005615 | |
| 0005765 | |
| 0046872 | |
| 0016491 | |
| 0006811 | |
| 0055114 | |
| 0046688 | |
| 0006810 | |
| 0046658 | |
| 0007568 | |
| 0001889 | |
| 0030324 | |
| 0015679 | |
| 0007584 |
| Alias | CP-2 |
|---|---|
| ceruloplasmin | |
| D3Ertd555e | |
| ferroxidase | |
| CERP | |
| OTTMUSP00000027617 | |
| iron(II): oxygen oxidoreductases | |
| LOC294942 | |
| OTTHUMP00000215840 | |
| OTTHUMP00000215841 | |
| OTTMUSP00000027618 | |
| OTTMUSP00000027619 | |
| OTTMUSP00000027652 | |
| iron(II): oxygen oxidoreductase | |
| RATCERPs | |
| RATCERP | |
| ceruloplasmin (ferroxidase) | |
| caeruloplasmin | |
| ferroxidase, iron II:oxygen oxidoreductase | |
| GPI-anchored ceruloplasmin | |
| DNA segment, Chr 3, ERATO Doi 555, expressed | |
| ferro:O2 oxidoreductase | |
| ferro:O2 oxidoreductases | |
| ferroxidase I | |
| ferroxidase, iron II:oxygen oxidoreductases | |
| caeruloplasmins |
| Mouse chromosome position | 3 |
|---|
| OMIM ID | 117700 |
|---|---|
| 604290 |
| Rat chromosome position | 2q24 |
|---|
| Hugo ID | 2295 |
|---|
| Human chromosome position | 3q23-q25 |
|---|
| Swiss-Prot Accession | A5PL27 |
|---|---|
| P00450 | |
| G3X8Q5 | |
| Q61147 | |
| Q8BU82 | |
| G3V7K3 | |
| P13635 | |
| Q14063 | |
| Q2PP18 | |
| Q9UKS4 | |
| Q6P5C8 |
| PIR ID | A25443 |
|---|
| Unigene ID | Hs.558314 |
|---|---|
| Mm.13787 | |
| Rn.32777 |
| KEGG ID | hsa:1356 |
|---|---|
| mmu:12870 | |
| rno:24268 |
| Swiss-Prot ID | CERU_HUMAN |
|---|---|
| CERU_MOUSE |
| EC Number | 1.16.3.1 |
|---|
| Ensembl ID | ENSG00000047457 |
|---|---|
| ENSP00000264613 | |
| ENST00000264613 | |
| ENSMUSG00000003617 | |
| ENSMUSP00000103964 | |
| ENSMUST00000108328 | |
| ENSMUSP00000003714 | |
| ENSMUST00000003714 | |
| ENSMUSP00000088857 | |
| ENSMUST00000091309 | |
| ENSRNOG00000011913 | |
| ENSRNOP00000016083 | |
| ENSRNOT00000016083 |
| Homologene ID | 75 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88476 |
|---|
| RGD ID | 2387 |
|---|
| MedScan ID | 1356 |
|---|