| URN | urn:agi-llid:7037 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1390 |
| Name | Tfrc |
| Description | transferrin receptor |
| Notes | receptor for transferrin; involved in regulating stellate cell activation [RGD, Feb 2006] |
| GO Molecular Function | iron ion transmembrane transporter activity |
|---|---|
| peptidase activity | |
| transferrin receptor activity | |
| chaperone binding | |
| Hsp70 protein binding | |
| double-stranded RNA binding |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| integral component of membrane | |
| coated pit | |
| external side of plasma membrane | |
| integral component of plasma membrane | |
| recycling endosome membrane | |
| cell surface | |
| plasma membrane | |
| perinuclear region of cytoplasm | |
| endosome | |
| mitochondrion | |
| recycling endosome | |
| cytoplasmic membrane-bounded vesicle | |
| melanosome | |
| extracellular vesicular exosome |
| GO Biological Process | osteoclast differentiation |
|---|---|
| positive regulation of bone resorption | |
| aging | |
| transmembrane transport | |
| iron ion transmembrane transport | |
| cellular iron ion homeostasis | |
| transferrin transport | |
| response to inorganic substance | |
| response to organic substance | |
| response to nutrient | |
| response to retinoic acid | |
| response to iron ion | |
| response to copper ion | |
| response to manganese ion | |
| response to hypoxia | |
| acute-phase response | |
| proteolysis | |
| endocytosis | |
| receptor-mediated endocytosis | |
| modulation by virus of host morphology or physiology |
| Pathway | Endosomal Recycling |
|---|---|
| Transcytosis | |
| Traffic and Degradation of Extracellular Amyloid beta in Alzheimer's Disease | |
| Proteins Involved in Pathogenesis of Glioma | |
| TGFB1-ACVRL1 Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| iron homeostasis pathway |
| Group | Transferrin receptor |
|---|---|
| osteoclast differentiation | |
| positive regulation of bone resorption | |
| aging | |
| transmembrane transport | |
| iron ion transmembrane transport | |
| iron ion transmembrane transporter activity | |
| cellular iron ion homeostasis | |
| transferrin transport | |
| response to inorganic substance | |
| response to organic substance | |
| response to nutrient | |
| response to retinoic acid | |
| response to iron ion | |
| response to copper ion | |
| response to manganese ion | |
| response to hypoxia | |
| acute-phase response | |
| peptidase activity | |
| proteolysis | |
| endocytosis | |
| receptor-mediated endocytosis | |
| transferrin receptor activity | |
| modulation by virus of host morphology or physiology | |
| chaperone binding | |
| Hsp70 protein binding | |
| double-stranded RNA binding | |
| membrane | |
| extracellular region | |
| integral component of membrane | |
| coated pit | |
| external side of plasma membrane | |
| integral component of plasma membrane | |
| recycling endosome membrane | |
| cell surface | |
| plasma membrane | |
| perinuclear region of cytoplasm | |
| endosome | |
| mitochondrion | |
| recycling endosome | |
| cytoplasmic membrane-bounded vesicle | |
| melanosome | |
| extracellular vesicular exosome | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 7037 |
|---|---|
| 22042 | |
| 64678 |
| Cell Localization | Plasma membrane |
|---|---|
| Cell membrane | |
| Melanosome | |
| Secreted |
| GO ID | 0003725 |
|---|---|
| 0008233 | |
| 0004998 | |
| 0006879 | |
| 0019048 | |
| 0030316 | |
| 0045780 | |
| 0006508 | |
| 0033572 | |
| 0055085 | |
| 0005905 | |
| 0016023 | |
| 0005768 | |
| 0009897 | |
| 0005576 | |
| 0070062 | |
| 0005887 | |
| 0042470 | |
| 0016020 | |
| 0048471 | |
| 0005886 | |
| 0030544 | |
| 0051087 | |
| 0005381 | |
| 0006897 | |
| 0034755 | |
| 0006898 | |
| 0009986 | |
| 0016021 | |
| 0005739 | |
| 0055037 | |
| 0055038 | |
| 0006953 | |
| 0007568 | |
| 0046688 | |
| 0001666 | |
| 0010035 | |
| 0010039 | |
| 0010042 | |
| 0007584 | |
| 0010033 | |
| 0032526 |
| Alias | T9 |
|---|---|
| TR | |
| TFR | |
| p90 | |
| CD71 | |
| TFR1 | |
| TRFR | |
| transferrin receptor protein 1 | |
| transferrin receptor (p90, CD71) | |
| Mtvr1 | |
| Mtvr-1 | |
| AI195355 | |
| AI426448 | |
| AU015758 | |
| 2610028K12Rik | |
| E430033M20Rik | |
| mammary tumor virus receptor 1 | |
| CD71 antigen | |
| TFR I | |
| TFR1_HUMAN | |
| TFRC mRNA | |
| Transferrin receptor | |
| Transferrin receptor 1 | |
| OTTHUMP00000208525 | |
| OTTMUSP00000033382 | |
| TFRC | |
| RIKEN cDNA 2610028K12 gene | |
| Transferrin receptors | |
| 2610028K12 | |
| Antigen CD71 | |
| E430033M20 | |
| mammary tumor virus receptor I | |
| mammary tumour virus receptor 1 | |
| mammary tumour virus receptor I |
| Mouse chromosome position | 16 23.06 cM |
|---|
| OMIM ID | 190010 |
|---|
| Rat chromosome position | 11q22 |
|---|
| Hugo ID | 11763 |
|---|
| Human chromosome position | 3q29 |
|---|
| Swiss-Prot Accession | P02786 |
|---|---|
| A8K6Q8 | |
| Q542D9 | |
| Q62351 | |
| G3V679 | |
| Q99376 | |
| D3DXB0 | |
| Q1HE24 | |
| Q59G55 | |
| Q9UCN0 | |
| Q9UCU5 | |
| Q9UDF9 | |
| Q9UK21 | |
| Q61560 |
| PIR ID | A93343 |
|---|---|
| S29548 |
| Unigene ID | Hs.529618 |
|---|---|
| Mm.28683 | |
| Rn.98672 |
| KEGG ID | hsa:7037 |
|---|---|
| mmu:22042 | |
| rno:64678 |
| Swiss-Prot ID | TFR1_HUMAN |
|---|---|
| TFR1_MOUSE |
| Ensembl ID | ENSG00000072274 |
|---|---|
| ENSP00000353224 | |
| ENST00000360110 | |
| ENSP00000376197 | |
| ENST00000392396 | |
| ENSMUSG00000022797 | |
| ENSMUSP00000023486 | |
| ENSMUST00000023486 | |
| ENSRNOG00000001766 | |
| ENSRNOP00000002407 | |
| ENSRNOT00000002407 |
| Homologene ID | 2429 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98822 |
|---|
| RGD ID | 70488 |
|---|
| MedScan ID | 7037 |
|---|