| URN | urn:agi-llid:55240 |
|---|---|
| Total Entities | 0 |
| Connectivity | 73 |
| Name | Steap3 |
| Description | STEAP family member 3, metalloreductase |
| Notes | induces apoptosis; inhibits prostate tumor growth in some cell lines [RGD, Feb 2006] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| cupric reductase activity | |
| ferric-chelate reductase (NADPH) activity | |
| ferric-chelate reductase activity | |
| metal ion binding |
| GO Cellular Component | membrane |
|---|---|
| cell | |
| integral component of membrane | |
| endosome membrane | |
| plasma membrane | |
| endosome | |
| multivesicular body |
| GO Biological Process | oxidation-reduction process |
|---|---|
| cell cycle | |
| transmembrane transport | |
| positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| protein secretion | |
| exosomal secretion | |
| ferric iron import into cell | |
| copper ion import | |
| cellular iron ion homeostasis | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| ion transport | |
| iron ion transport | |
| transferrin transport | |
| transport | |
| iron ion homeostasis |
| Pathway | iron homeostasis pathway |
|---|
| Group | Tumor suppressors |
|---|---|
| oxidation-reduction process | |
| oxidoreductase activity | |
| cupric reductase activity | |
| ferric-chelate reductase (NADPH) activity | |
| ferric-chelate reductase activity | |
| cell cycle | |
| transmembrane transport | |
| positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| protein secretion | |
| exosomal secretion | |
| ferric iron import into cell | |
| copper ion import | |
| cellular iron ion homeostasis | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| ion transport | |
| iron ion transport | |
| transferrin transport | |
| transport | |
| iron ion homeostasis | |
| metal ion binding | |
| membrane | |
| cell | |
| integral component of membrane | |
| endosome membrane | |
| plasma membrane | |
| endosome | |
| multivesicular body | |
| Secreted proteins |
| LocusLink ID | 55240 |
|---|---|
| 68428 | |
| 170824 |
| Cell Localization | Endosome membrane |
|---|
| GO ID | 0000293 |
|---|---|
| 0046872 | |
| 0006915 | |
| 0007049 | |
| 0006879 | |
| 0009306 | |
| 0033572 | |
| 0055085 | |
| 0010008 | |
| 0016021 | |
| 0005771 | |
| 0005886 | |
| 0008823 | |
| 0052851 | |
| 0016491 | |
| 0015677 | |
| 1990182 | |
| 0097461 | |
| 0006811 | |
| 0055072 | |
| 0006826 | |
| 0055114 | |
| 0043065 | |
| 1902167 | |
| 0006810 | |
| 0005623 | |
| 0005768 | |
| 0016020 |
| Alias | STMP3 |
|---|---|
| TSAP6 | |
| AHMIO2 | |
| dudlin-2 | |
| metalloreductase STEAP3 | |
| pHyde | |
| hTSAP6 | |
| hpHyde | |
| dudlin 2 | |
| dudulin 2 | |
| dudulin-2 | |
| 1010001D01Rik | |
| tumor suppressor pHyde | |
| six transmembrane prostate protein 3 | |
| tumor suppressor-activated pathway protein 6 | |
| six-transmembrane epithelial antigen of prostate 3 | |
| protein nm1054 | |
| STEAP family member 3, metalloreductase | |
| six transmembrane prostate protein III | |
| OTTMUSP00000023906 | |
| OTTMUSP00000023907 | |
| OTTMUSP00000023905 | |
| STEAP3 | |
| tumour suppressor phyde | |
| dudlin | |
| OTTMUSP00000023904 | |
| LOC170824 | |
| dudlin II | |
| dudulin II | |
| OTTMUSP00000023903 | |
| MGC93147 | |
| OTTHUMP00000162092 | |
| OTTHUMP00000162093 | |
| OTTHUMP00000203624 | |
| FLJ10829 | |
| 1010001D01 |
| Mouse chromosome position | 1 |
|---|
| OMIM ID | 609671 |
|---|---|
| 615234 |
| Rat chromosome position | 13q11 |
|---|
| Hugo ID | 24592 |
|---|
| Human chromosome position | 2q14.2 |
|---|
| Swiss-Prot Accession | Q658P3 |
|---|---|
| B8ZZX6 | |
| Q8CI59 | |
| Q5RKL5 | |
| Q3TKE4 | |
| Q80ZF3 | |
| Q8C5F0 | |
| Q924Z1 | |
| Q99P41 | |
| A8K6E3 | |
| Q4VBR2 | |
| Q4ZG36 | |
| Q53SQ8 | |
| Q7Z389 | |
| Q86SF6 | |
| Q8NEW6 | |
| Q8TDP3 | |
| Q8TF03 | |
| Q9NVB5 |
| Unigene ID | Hs.647822 |
|---|---|
| Mm.181033 | |
| Rn.16304 |
| KEGG ID | hsa:55240 |
|---|---|
| mmu:68428 | |
| rno:170824 |
| Swiss-Prot ID | STEA3_MOUSE |
|---|---|
| STEA3_RAT | |
| STEA3_HUMAN |
| EC Number | 1.16.1.- |
|---|
| Ensembl ID | ENSG00000115107 |
|---|---|
| ENSP00000376820 | |
| ENST00000393108 | |
| ENSP00000376818 | |
| ENST00000393106 | |
| ENSP00000376822 | |
| ENST00000393110 | |
| ENSMUSG00000026389 | |
| ENSMUSP00000108258 | |
| ENSMUST00000112639 | |
| ENSMUSP00000108259 | |
| ENSMUST00000112640 | |
| ENSRNOG00000049471 | |
| ENSRNOP00000064137 | |
| ENSRNOT00000071388 |
| Homologene ID | 10084 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1915678 |
|---|
| RGD ID | 708552 |
|---|
| MedScan ID | 55240 |
|---|