Elsevier Inc. Fe3+ ferritin complex ---- Slc11a2 Slc39a8 Slc11a2 ---> non-heme poly(rC) targets Cp Heph Hamp Slc40a1 Fbxl5 Ireb2-deg Ireb2 Aco1-ISC Aco1 Ftmt Slc25a28 Slc25a37 Ncoa4 dietary, non-heme Fe NTBI Fe2+ Slc39a14 Prnp Cybrd1 Steap3 eSlc11a2 Slc11a2 Tfrc Tf Aco1 ---| 5'-UTR IRE genes Ireb2 --+> 3'-UTR IRE genes autophagosome iron efflux pathway iron uptake pathway cytosolic iron-sulfur cluster protein assembly pathway mitochondrial iron-sulfur cluster protein biogenesis pathway heme biosynthetic pathway 3'-UTR IRE genes 5'-UTR IRE genes 5'-UTR IRE poly(rC) chaperones non-heme poly(rC) targets ferritin complex Tf ---- Tfrc Fe3+ ---- Tf NTBI ---> Slc11a2 dietary, non-heme Fe ---> Slc39a8 dietary, non-heme Fe ---> Slc39a14 Hamp ---- Slc40a1 5'-UTR IRE ---- Aco1 3'-UTR IRE ---- Aco1 5'-UTR IRE ---- Ireb2 3'-UTR IRE 3'-UTR IRE ---- Ireb2 Fbxl5 ---> Ireb2-deg Fbxl5 ---| Ireb2-deg ferritin complex ---- Ncoa4 ferritin complex ---> autophagosome Hamp ---| Slc40a1 non-heme poly(rC) targets ---- poly(rC) chaperones Fe2+ ---- poly(rC) chaperones poly(rC) chaperones ---- Slc11a2 ferritin complex ---- poly(rC) chaperones iron storage pathway