| Hugo ID | 2363 |
|---|---|
| Name | Crkl |
| Description | v-crk sarcoma virus CT10 oncogene homolog (avian)-like |
| Notes | v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. |
| Owner | Public |
| URN | urn:agi-llid:1399 |
| Connectivity | 181 |
| Source | Curated |
|---|
| LocusLink ID | 1399 |
|---|---|
| 12929 | |
| 287942 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602007 |
|---|
| Alias | v-crk sarcoma virus CT10 oncogene homolog (avian)-like |
|---|---|
| v-crk avian sarcoma virus CT10 oncogene homolog-like | |
| Crkol | |
| AA589403 | |
| AI325100 | |
| 1110025F07Rik |
| GO ID | 0005070 |
|---|---|
| 0005515 | |
| 0004713 | |
| 0007254 | |
| 0007265 | |
| 0006928 | |
| 0007242 | |
| 0006468 | |
| 0050875 | |
| 0009887 | |
| 0000074 | |
| 0005622 |
| Swiss-Prot Accession | P46109 |
|---|---|
| P47941 | |
| Q5U2U2 |
| Unigene ID | Hs.592205 |
|---|---|
| Mm.21048 | |
| Rn.35110 |
| RGD ID | 1308531 |
|---|
| MGI ID | 104686 |
|---|
| Pathway | SAPK-JNK Signaling |
|---|---|
| EPHA3 | |
| Integrin Signaling | |
| scatter factor-hepatocyte growth factor signaling pathway |
| Group | Kinases |
|---|---|
| Sh2 | |
| cellular physiological process | |
| intracellular signaling cascade | |
| JNK cascade | |
| Ras protein signal transduction | |
| cell motility | |
| regulation of progression through cell cycle | |
| protein amino acid phosphorylation | |
| organ morphogenesis | |
| intracellular | |
| protein binding | |
| SH3-SH2 adaptor activity | |
| protein-tyrosine kinase activity |