| Hugo ID | 1541 |
|---|---|
| Name | Cbl |
| Description | similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (predicted) |
| Notes | The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. |
| Owner | Public |
| URN | urn:agi-llid:867 |
| Connectivity | 792 |
| Source | Curated |
|---|
| LocusLink ID | 867 |
|---|---|
| 12402 | |
| 500985 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 165360 |
|---|
| Alias | CBL2 |
|---|---|
| C-CBL | |
| RNF55 | |
| Cas-Br-M (murine) ecotropic retroviral transforming sequence | |
| oncogene CBL2 | |
| cbl | |
| Cbl-2 | |
| 4732447J05Rik | |
| Casitas B-lineage lymphoma | |
| similar to CBL E3 ubiquitin protein ligase (Signal transduction protein CBL) (predicted) |
| GO ID | 0005509 |
|---|---|
| 0016874 | |
| 0005515 | |
| 0004871 | |
| 0003700 | |
| 0004842 | |
| 0008270 | |
| 0007166 | |
| 0007173 | |
| 0007242 | |
| 0048260 | |
| 0016567 | |
| 0005634 | |
| 0005886 | |
| 0046872 | |
| 0006512 |
| Swiss-Prot Accession | P22681 |
|---|---|
| Q8NAQ6 | |
| P22682 |
| Unigene ID | Hs.504096 |
|---|---|
| Mm.266871 |
| RGD ID | 1561386 |
|---|
| MGI ID | 88279 |
|---|
| Cell Localization | Nucleus |
|---|
| Pathway | Insulin Receptor Signaling |
|---|---|
| EPHA3 | |
| ITGAM/ITGB2 -> CEBPB signaling pathway | |
| ITGAM/ITGB2 -> NF-kB signaling pathway | |
| TNFRSF5/13B -> NFATC1 signaling pathway | |
| scatter factor-hepatocyte growth factor signaling pathway |
| Group | Sh2 |
|---|---|
| Ubiquitin ligases | |
| cell surface receptor linked signal transduction | |
| intracellular signaling cascade | |
| epidermal growth factor receptor signaling pathway | |
| ubiquitin cycle | |
| protein ubiquitination | |
| positive regulation of receptor mediated endocytosis | |
| nucleus | |
| plasma membrane | |
| signal transducer activity | |
| protein binding | |
| metal ion binding | |
| calcium ion binding | |
| zinc ion binding | |
| transcription factor activity | |
| ligase activity | |
| ubiquitin-protein ligase activity |