| Hugo ID | 4066 |
|---|---|
| Name | Gab1 |
| Description | growth factor receptor bound protein 2-associated protein 1 (predicted) |
| Notes | The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. |
| Owner | Public |
| URN | urn:agi-llid:2549 |
| Connectivity | 303 |
| Source | Curated |
|---|
| LocusLink ID | 2549 |
|---|---|
| 14388 | |
| 361388 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604439 |
|---|
| Alias | GRB2-associated binding protein 1 |
|---|---|
| AA408973 | |
| AW107238 | |
| growth factor receptor bound protein 2-associated protein 1 | |
| growth factor receptor bound protein 2-associated protein 1 (predicted) |
| GO ID | 0005070 |
|---|---|
| 0005515 | |
| 0008283 | |
| 0007173 | |
| 0008286 | |
| 0004872 | |
| 0004871 | |
| 0007257 | |
| 0000187 | |
| 0030334 | |
| 0006979 | |
| 0007165 | |
| 0005737 |
| Swiss-Prot Accession | Q13480 |
|---|---|
| Q4W5G2 | |
| Q6P1W2 | |
| Q8TE87 | |
| Q9HA84 | |
| Q505A4 | |
| Q9QYY0 |
| Unigene ID | Hs.80720 |
|---|---|
| Hs.618456 | |
| Mm.277409 |
| RGD ID | 1311085 |
|---|
| MGI ID | 108088 |
|---|
| Cell Localization | Plasma membrane |
|---|
| Pathway | Jnk-mapk |
|---|---|
| HGF | |
| Insulin Receptor Signaling | |
| EDG2 -> ELK4-SRF signaling pathway | |
| NTRK1 -> MYCN signaling pathway | |
| NTRK1 -> SMAD3 signaling pathway | |
| NTRKs -> AP-1 signaling pathway | |
| NTRKs -> CREB1 signaling pathway | |
| NTRKs -> ELK1-SRF signaling pathway | |
| NTRKs -> ELK4-SRF signaling pathway | |
| NTRKs -> FOXO1A signaling pathway | |
| NTRKs -> FOXO3A signaling pathway | |
| NTRKs -> MYC signaling pathway | |
| NTRKs -> STAT5A signaling pathway | |
| NTRKs -> TP53 signaling pathway | |
| EDG2 -> ELK1-SRF signaling pathway | |
| scatter factor-hepatocyte growth factor signaling pathway |
| Group | Ph |
|---|---|
| signal transduction | |
| epidermal growth factor receptor signaling pathway | |
| insulin receptor signaling pathway | |
| activation of MAPK activity | |
| activation of JNK activity | |
| cell proliferation | |
| regulation of cell migration | |
| response to oxidative stress | |
| cytoplasm | |
| signal transducer activity | |
| protein binding | |
| SH3-SH2 adaptor activity | |
| receptor activity |