| Hugo ID | 8979 |
|---|---|
| Name | Pik3r1 |
| Description | similar to phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 |
| Notes | It has recently been shown that Akt activation is associated with a worse outcome among endocrine treated breast cancer patients and that it also inhibits the progesterone receptor (PR) expression via the PI3K/Akt pathway in breast cancer cells. It has recently been shown that Akt activation is associated with a worse outcome among endocrine treated breast cancer patients and that it also inhibits the progesterone receptor (PR) expression via the PI3K/Akt pathway in breast cancer cells. PI3K regulates cell cycle progression and cell proliferation in human gastric tumor cells via Rb-mediated pathway; effect mediated through direct association with Rb via N-terminal end of its p55 kDa regulatory subunits and modulating Rb-E2F interactions. Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms. RhoG protects cells from apoptosis caused by the loss of anchorage through a PI3K-dependent mechanism, independent of its activation of Rac1. These results support a model in which phagosomal PI3K generates PI(3,4,5)P(3) necessary for later stages of phagocytosis, PTEN determines whether those late stages can occur, and SHIP-1 regulates when and where they occur. Constitutively active Stat5 mutant forms a complex with the p85 subunit of phosphatidylinositol 3-kinase and the scaffolding adapter Gab2 in leukemic bone marrow cells, resulting in the activation of Akt/PKB, a crucial downstream target of PI3-K. Direct interactions between native Syk and PI3K proteins are differentially regulated during FcgammaR phagocytosis and endocytosis. Protein whose expression is deregulated in the epidermis of the elderly. |
| Owner | Public |
| URN | urn:agi-llid:5295 |
| Connectivity | 231 |
| Source | Curated |
|---|---|
| GO component |
| LocusLink ID | 5295 |
|---|---|
| 25513 | |
| 153387 | |
| 18708 | |
| 105088 | |
| 328326 | |
| 360334 | |
| 282307 | |
| 557176 |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 171833 |
|---|
| Alias | GRB1 |
|---|---|
| p85-ALPHA | |
| phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 | |
| phosphatidylinositol 3-kinase, regulatory, 1 | |
| phosphatidylinositol 3-kinase-associated p-85 alpha | |
| phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | |
| phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | |
| PI3KA | |
| phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 | |
| Phosphoinositide 3-kinase p85 | |
| Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | |
| phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 | |
| phosphatidylinositol 3-kinase, regulatory subunit, polypeptide I | |
| phosphoinositide 3-kinase, regulatory subunit, polypeptide I | |
| Phosphatidylinositol 3-kinase regulatory alpha subunit | |
| phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha | |
| PI3-kinase P85- alpha subunit | |
| PtdIns-3-kinase P85-alpha | |
| hypothetical gene supported by AK049798 | |
| P85A_HUMAN | |
| Phosphatidylinositol 3-kinase, regulatory | |
| LOC153387 | |
| expressed sequence AA414921 | |
| Phosphatidylinositol 3-kinase, regulatory, I | |
| AA414921 | |
| 3-phosphatidylinositol kinase 85K chain | |
| Pik3r1 | |
| p50alpha | |
| p55alpha | |
| Pik3r I | |
| GRB I | |
| P(85)A | |
| P-85A | |
| P85-A | |
| C530050K14 | |
| p85alpha regulatory subunit of phosphoinositide 3-kinase | |
| p85a | |
| P 85A | |
| Phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | |
| LOC557176 | |
| chromosome | |
| polypeptide 1 | |
| regulatory subunit | |
| scaffold | |
| similar to phosphoinositide-3-kinase | |
| similar to phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 |
| GO ID | 0043125 |
|---|---|
| 0043559 | |
| 0005158 | |
| 0043560 | |
| 0005159 | |
| 0016301 | |
| 0005545 | |
| 0035014 | |
| 0019903 | |
| 0008286 | |
| 0048009 | |
| 0007242 | |
| 0046854 | |
| 0005622 | |
| 0005942 | |
| 0035030 | |
| 0016303 | |
| 0008022 | |
| 0005515 | |
| 0030183 | |
| 0043066 | |
| 0006468 | |
| 0005737 | |
| 0005829 | |
| 0016020 | |
| 0007165 | |
| 0005102 | |
| 0001953 | |
| 0030335 | |
| 0045671 | |
| 0005886 | |
| 0006006 | |
| 0007568 | |
| 0032868 | |
| 0043627 | |
| 0045663 | |
| 0045768 | |
| 0045861 | |
| 0051384 | |
| 0051591 |
| Swiss-Prot Accession | P27986 |
|---|---|
| Q15747 | |
| Q4VBZ7 | |
| Q53EM6 | |
| Q8IXA2 | |
| Q8N1C5 | |
| O55168 | |
| Q63787 |
| Unigene ID | Hs.132225 |
|---|---|
| Hs.604502 | |
| Rn.10599 | |
| Mm.259333 | |
| Bt.91714 | |
| Dr.77293 |
| RGD ID | 3329 |
|---|
| MGI ID | 97583 |
|---|---|
| 2145159 |
| Cell Localization | Cytoplasm |
|---|
| Pathway | insulin signaling pathway |
|---|---|
| scatter factor-hepatocyte growth factor signaling pathway |
| Group | Sh2 |
|---|---|
| intracellular signaling cascade | |
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| B cell differentiation | |
| negative regulation of apoptosis | |
| phosphoinositide phosphorylation | |
| protein amino acid phosphorylation | |
| intracellular | |
| phosphoinositide 3-kinase complex | |
| phosphoinositide 3-kinase complex, class IA | |
| protein binding | |
| insulin binding | |
| phosphatidylinositol binding | |
| insulin receptor substrate binding | |
| protein C-terminus binding | |
| protein phosphatase binding | |
| insulin receptor binding | |
| insulin-like growth factor receptor binding | |
| ErbB-3 class receptor binding | |
| kinase activity | |
| phosphatidylinositol 3-kinase activity | |
| phosphoinositide 3-kinase regulator activity |
| Homo sapiens Chromosome position | 5q13.1 |
|---|
| Microarray ID | 96592_at |
|---|---|
| 244181_at | |
| 212239_at | |
| 212240_s_at | |
| 1425514_at | |
| 1425515_at | |
| 1438682_at |
| GO Molecular Function | protein binding |
|---|---|
| insulin binding | |
| phosphatidylinositol binding | |
| insulin receptor substrate binding | |
| protein C-terminus binding | |
| protein phosphatase binding | |
| insulin receptor binding | |
| insulin-like growth factor receptor binding | |
| ErbB-3 class receptor binding | |
| kinase activity | |
| phosphatidylinositol 3-kinase activity | |
| phosphoinositide 3-kinase regulator activity |
| Rat chromosome position | 2q12 |
|---|
| Human chromosome position | 5q13.1 |
|---|
| FunctionalClass | ErbB-3 class receptor binding |
|---|---|
| insulin binding | |
| insulin receptor binding | |
| insulin receptor substrate binding | |
| insulin-like growth factor receptor binding | |
| phosphatidylinositol binding | |
| phosphoinositide 3-kinase regulator | |
| protein phosphatase binding | |
| kinase | |
| phosphatidylinositol 3-kinase | |
| protein binding | |
| protein C-terminus binding | |
| receptor binding | |
| 1-phosphatidylinositol-3-kinase |
| GO Biological Process | intracellular signaling cascade |
|---|---|
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling path | |
| B cell differentiation | |
| negative regulation of apoptosis | |
| phosphoinositide phosphorylation | |
| protein amino acid phosphorylation | |
| negative regulation of cell-matrix adhesion | |
| negative regulation of osteoclast differentiation | |
| positive regulation of cell migration | |
| signal transduction | |
| aging | |
| glucose metabolic process | |
| negative regulation of proteolysis | |
| positive regulation of anti-apoptosis | |
| positive regulation of myoblast differentiation | |
| response to cAMP | |
| response to estrogen stimulus | |
| response to glucocorticoid stimulus | |
| response to insulin stimulus |
| GO Cellular Component | intracellular |
|---|---|
| phosphoinositide 3-kinase complex | |
| phosphoinositide 3-kinase complex, class IA | |
| cytoplasm | |
| cytosol | |
| membrane | |
| plasma membrane |
| Bos taurus Chromosome position | 20 |
|---|
| Mus musculus Chromosome position | 13 50.0 cM |
|---|---|
| 13 | |
| 13 D1 |
| Rattus norvegicus Chromosome position | 2q12 |
|---|