Protein : Grb2

Hugo ID 4566
Name Grb2
Description growth factor receptor bound protein 2
Notes acts as a link between tyrosine kinase receptors and Ras signaling [RGD]
Owner Public
URN urn:agi-llid:2885
Connectivity 772

Source Curated
ResNet
GO component

GenBank ID NC_000017
NM_002086
NP_002077
NM_203506
NP_987102
NT_010641
NW_926918
AC_000060
AC011933
AF063618
AAC72075
AA452034
AF171699
AAQ13606
AF246238
AAG44485
AF302079
AAG27442
AF498925
AAM21073
AK024539
BAB14923
AK091010
BC000631
AAH00631
BC009417
BC019082
BC033644
BC039827
BC043007
BI459414
BQ073225
BQ962129
CR450363
CAG29359
CR541942
CAG46740
L29511
AAC37549
M96995
AAA58448
X62852
CAA44664
P62993
Q6ICN0
Q7Z4F5
Q9H2Q4
Q9H7G8
Q9HAU2
NC_000077
NM_008163
NP_032189
NT_165773
NW_000040
NW_001030434
AC_000033
AL645852
AL732491
AI323718
AK077750
AK079087
AK148148
BAE28376
AK153557
BAE32093
AK155800
BAE33439
AK166142
BAE38595
AK170845
BAE42068
AK172002
AK177056
AK180406
AK181485
AK192421
AK196759
AK211391
BC052377
AAH52377
BC085254
AAH85254
BG064712
BG078047
D85748
BAA12862
U07617
AAB40022
Q60631
NC_005109
NM_030846
NP_110473
NW_001084656
NW_047343
AC_000078
AA926364
BC091144
AAH91144
D49846
BAA08645
D49847
BAA08646
D49848
BAA08647
X62853
CAA44665
P62994
Q5BKA7
Q63058
10436844
11036973
119609676
119609677
12005511
123996495
12653693
181976
20379026
28876
33337968
3850302
47496673
49456839
498178
51702266
74713500
74718116
74718671
74718692
74748763
ABM85849
CH471099
DQ894923
EAW89270
EAW89271
31455236
AAH09417
123787434
123796999
1375041
2498425
30851533
464005
55154544
74141681
74152124
74195307
74214845
74221133
Q3U1Q4
Q3U5I5
AA408164
51702260
55763
60552087
81890319
914957
914959
914961
NT_086886
NT_096135
122145087
74354609
AAI02412
BC102411
NC_007317
NM_001034630
NP_001029802
NW_001493695
Q3T0F9
AI416149
AI522340
AI415824
AI436912
37590325
82237673
AAH59450
BC059450
BX465842
NC_007114
NM_213035
NP_998200
NW_001513105
Q6PC73
119609678
123981854
ABM82756
DA458680
DQ891830
EAW89272
123228035
123228036
123228037
123267549
123267550
123267551
123267552
148702568
148702569
148702570
CAM19836
CAM19837
CAM19838
CAM21965
CAM21966
CAM21967
CAM21968
CH466558
EDL34515
EDL34516
EDL34517
149054787
149054788
CH473948
EDM06604
EDM06605
54261768
126007508
42558029
54261769
ZDB-GENE-030131-258
ZDB-GENE-030131-504
406308
Dr.114331
Dr.74564
ZDB-GENE-040426-1975
dre:406308

LocusLink ID 2885
14784
81504
80299
80715
103536
281211
535298
406308
321539
321785

Organism Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio

OMIM ID 108355

Alias ASH
Grb3-3
MST084
MSTP084
EGFRBP-GRB2
growth factor receptor-bound protein 2
HT027
abundant SRC homology
growth factor receptor-bound protein 3
epidermal growth factor receptor-binding protein GRB2
AA408164
growth factor receptor bound protein 2
MGC108668
HT-027
HT(027)
HT 027
hypothetical protein FLJ20886
SH2/SH3 adapter GRB2
Grb3-3s
Grb2
GRB2 adapter protein
Growth factor receptor-bound protein II
FLJ20886
Grb3 III
GRB2_HUMAN
fb18e12
wu:fb18e12
fb34e06
wu:fb34e06
chromosome
scaffold
zgc:73077

GO ID 0005070
0005154
0043560
0007265
0007267
0007173
0008286
0007242
0005829
0005515
0004872
0000165
0005737
0016020
0012506
0001784
0051291
0051219

Swiss-Prot Accession P62993
Q6ICN0
Q7Z4F5
Q9H2Q4
Q9H7G8
Q9HAU2
Q60631
P62994
Q5BKA7
Q63058

Unigene ID Hs.444356
Hs.633064
Mm.383426
Rn.3360
Rn.163461
Hs.651330
Mm.6900
Bt.8815
Dr.114331
Dr.74564
Hs.699367
Mm.439649

RGD ID 619758

MGI ID 95805
2143976

Cell Localization Cytoplasm

Pathway LT-alpha
p40 MAPK
HGF
Insulin Receptor Signaling
RANKL
Neurotensin
Antiapoptotic Pathways From IGF-1R
Jak-Stat Pathway from IL6 Receptor
Insulin pathway
EGF signaling
EPHB1
PDGFRB
p38 Signaling
PDGF signaling
opioids OPRD1
TNF-alpha
MAPK-ERK in Growth and Differentiation
PDGFRA
Erythropoietin signaling
IL-6 signaling
G-protein Coupled Receptor signaling
Bombesin
Oxytocin
PTEN signaling
SAPK-JNK Signaling
IL-3 signaling
CREB signaling
EPHA2
Vasopressin
IL-2 signaling
Cholecystokinin
Gastrin
Substance P
NGF signaling
Endothelin
IL-1 and IL-6 signaling
EGF
Integrin Signaling
Nociceptin
AGTR1 -> ELK1-SRF signaling pathway
PTPRC -> BCL6 signaling pathway
AGTR1 -> ELK4-SRF signaling pathway
EDG2 -> ELK4-SRF signaling pathway
AGTR1 -> TP53 signaling pathway
AGTR2 -> CREB1 signaling pathway
EGFR -> AP-1 signaling pathway
AGTR2 -> ELK1-SRF signaling pathway
AGTR2 -> ELK4-SRF signaling pathway
NTRK1 -> SMAD3 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
AGTR2 -> TP53 signaling pathway
ERBB2 -> ETV4 signaling pathway
EGFR -> ATF2 signaling pathway
EGFR -> SMAD1 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> STAT5A signaling pathway
NTRKs -> TP53 signaling pathway
IGF1R -> ELK1-SRF signaling pathway
EGFR/ERBB2 -> HIF1A signaling pathway
ERBB2/3 -> SP1 signaling pathway
IGF1R -> ELK4-SRF signaling pathway
IGF1R -> HIF1A signaling pathway
IGF1R -> MYC signaling pathway
IGF1R -> SREBF1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
F2R -> AP-1 signaling pathway
PECAM1 -> SP1 signaling pathway
PLAUR -> ELK1-SRF signaling pathway
RET -> HSF1 signaling pathway
PLAUR -> ELK4-SRF signaling pathway
F2R -> CREB1 signaling pathway
F2R -> ELK1-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
F2R -> SP1 signaling pathway
EPOR -> ELK1-SRF signaling pathway
EPOR -> ELK4-SRF signaling pathway
SELE -> ELK1-SRF signaling pathway
EPOR -> FOS signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
SELE -> ELK4-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
ERBB2 -> EP300 signaling pathway
ERBB2 -> ETS1 signaling pathway
ERBB2 -> ETS2 signaling pathway
ERBB2 -> ETV1 signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL2R -> MYC signaling pathway
T-cell receptor -> AP-1 signaling pathway
IL4R -> ELK1-SRF signaling pathway
IL4R -> ELK4-SRF signaling pathway
IL4R -> HMGY signaling pathway
IL6R -> CEBPB signaling pathway
FGFRs -> RUNX2 signaling pathway
IL6R -> ELK1-SRF signaling pathway
IL6R -> ELK4-SRF signaling pathway
INSR -> ELK1-SRF signaling pathway
INSR -> ELK4-SRF signaling pathway
INSR -> SREBF1 signaling pathway
INSR -> SREBF2 signaling pathway
ITGB1 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> SREBF1 signaling pathway
ITGB1 -> SREBF2 signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
GFRs -> ELK1-SRF signaling pathway
ADRA1B -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
GFRs -> NCOR2 signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
KDR -> NFATC1 signaling pathway
KIT -> MITF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
CHRNA7 -> CREB1 signaling pathway
ADRA1B -> ELK4-SRF signaling pathway
GHR -> ELK4-SRF signaling pathway
GHR -> MYC signaling pathway
LEPR -> ELK1-SRF signaling pathway
ADRA1B -> STAT3 signaling pathway
LEPR -> ELK4-SRF signaling pathway
GRM1/5 -> CREB1 signaling pathway
MPL -> CREB1 signaling pathway
MPL -> SP1 signaling pathway
MPL -> SPI1 signaling pathway
NCAM1 -> CREB1 signaling pathway
NCAM1 -> ELK1-SRF signaling pathway
NCAM1 -> ELK4-SRF signaling pathway
NCAM1 -> MYC signaling pathway
TNFRSF1A -> AP-1 signaling pathway
TNFRSF1A -> ATF2 signaling pathway
DRD2 -> AP-1 signaling pathway
TNFRSF1A -> CREB1 signaling pathway
TNFRSF1A -> ELK1-SRF signaling pathway
TNFRSF1A -> ELK4-SRF signaling pathway
DRD2 -> CREB1 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
AGTR1 -> CREB1 signaling pathway
TNFRSF1A -> TP53 signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDG2 -> ELK1-SRF signaling pathway
insulin signaling pathway
insulin signaling pathway
scatter factor-hepatocyte growth factor signaling pathway

Group Sh2
cell-cell signaling
intracellular signaling cascade
epidermal growth factor receptor signaling pathway
insulin receptor signaling pathway
MAPKKK cascade
Ras protein signal transduction
membrane
cytoplasm
cytosol
vesicle membrane
protein binding
insulin receptor substrate binding
SH3-SH2 adaptor activity
epidermal growth factor receptor binding
receptor activity

Homo sapiens Chromosome position 17q24-q25
17q25.3

Mouse chromosome position 11 75.0 cM

Microarray ID 101034_at

GO Molecular Function protein binding
insulin receptor substrate binding
SH3-SH2 adaptor activity
epidermal growth factor receptor binding
receptor activity

Rat chromosome position 10q32.3

Human chromosome position 17q24-q25

FunctionalClass SH3/SH2 adaptor
epidermal growth factor receptor binding
insulin receptor substrate binding
protein binding
receptor
phosphotyrosine binding
phosphoprotein binding

GO Biological Process cell-cell signaling
intracellular signaling cascade
epidermal growth factor receptor signaling pathway
insulin receptor signaling pathway
MAPKKK cascade
Ras protein signal transduction
protein heterooligomerization

GO Cellular Component membrane
cytoplasm
cytosol
vesicle membrane

Bos taurus Chromosome position 19

Mus musculus Chromosome position 11 75.0 cM
11

MedScan ID 2885

KEGG pathway Chronic myeloid leukemia
Colorectal cancer
Dorso-ventral axis formation
Endometrial cancer
ErbB signaling pathway
Fc epsilon RI signaling pathway
Focal adhesion
Gap junction
Glioma
GnRH signaling pathway
Huntington's disease
Insulin signaling pathway
Jak-STAT signaling pathway
MAPK signaling pathway
Natural killer cell mediated cytotoxicity
Neurodegenerative Disorders
Non-small cell lung cancer
Renal cell carcinoma
T cell receptor signaling pathway

MedLine Reference 10022833
10051406
10068651
10077576
10080542
10086340
10087612
10224664
10319320
10329689
10330178
10339567
10354709
10359574
10377264
10386953
10455176
10467411
10469124
10477741
10488157
10490839
10521483
10559276
10602027
10636929
10660596
10706702
10747847
10748052
10781580
10781592
10790433
10820378
10899172
10900203
10903901
10940627
10940929
10970810
10973965
10982817
11071869
11094073
11127814
11133830
11152963
11157975
11173924
11278583
11278754
11292345
11314042
11352655
11371563
11384839
11432792
11433379
11439336
11466354
11483358
11509578
11527382
11533253
11546790
11551227
11551923
11571277
11606575
11707404
11707405
11711534
11726515
11733534
11739737
11741599
11741929
11877424
11882361
11897833
11923305
11960376
11964172
11997181
11997436
12006650
12007418
12023017
12112020
12149229
12162872
12171928
12186904
12220636
12242006
12242309
12345679
12359715
12388170
12399475
12400011
12402043
12424224
12441060
12477932
12485888
12514734
12522133
12529371
12531430
12577067
12624098
12730204
12748278
12852788
13129930
1322798
1384039
14667819
14679214
14702039
14722116
15122321
15173068
15182856
15187135
15314156
15326489
15368963
15467741
15546961
15556869
15635092
15688026
15879090
16038803
16249387
16298995
16339550
16382132
16407827
16729043
16730941
16760435
16818765
16906159
16955467
7478529
7486658
7488076
7488107
7500025
7510700
7511210
7518772
7524086
7527043
7534299
7535773
7544353
7556090
7559579
7629138
7629168
7642542
7664271
7675449
7675451
7706237
7716522
7737275
7737969
7744812
7759531
7798267
7799925
7806213
7806216
7809090
7929073
7935391
7970715
7982917
7997267
8022809
8041791
8063801
8112292
8119878
8178156
8188688
8253073
8262059
8388384
8479541
8491186
8493579
8536716
8547634
8570203
8576157
8585605
8585965
8621483
8621719
8630373
8631894
8633037
8647288
8649368
8649391
8662748
8662889
8662907
8662998
8663276
8670205
8670803
8695800
8700507
8702859
8723348
8780727
8798570
8810325
8816480
8887653
8918464
8943348
8955163
8986819
8994038
8995445
9009162
9013873
9016807
9019171
9038219
9045636
9045692
9050991
9079622
9108392
9135065
9171350
9178760
917890
9178909
9178913
9182757
9233773
9281317
9295052
9299436
9307968
9341187
9344857
9346925
9368064
9380408
9388224
9393871
9395447
9422736
9480847
9484780
9489702
9507006
9516488
9544989
9553137
9569023
9590294
9632636
9632781
9660480
9660791
9668219
9670936
9694876
9697839
9705962
9716598
9722576
9733714
9788432
9824671
9830057
9843378
9846481
9852124
9856458
9891051
9891069
9927207
10349636
10373493
10922068
10930041
11042159
11076861
11135575
11163269
11217851
11369229
11567986
11809799
11885979
12084912
12147689
12466851
12573256
12639989
12842846
1465135
15054097
15102471
15210125
15306695
15456754
15492213
15539154
15569713
15630473
15736129
15782199
15953601
15983387
16141072
16141073
16339969
16400024
16405865
16678776
16725108
16890200
16908534
7499280
7689150
7797522
7862126
8632004
8898205
8923966
9294143
9865697
12084708
12837289
12837295
12891559
15272025
15469895
17202467
7775428
8889548
9271418
10022120
10090780
10318918
10395476
10942756
11063574
11827484
12486104
15489334
16344560
17081983
17466257
17616655
7881903
8794768
9062191
9642078
10809671
14610044
15477348
15477350
16314834
16436051
17040971
17290227
17449471
9135122
11498538
13679576
8183574
8910399

Rattus norvegicus Chromosome position 10q32.3

Danio rerio Chromosome position LG 3