Protein : Shc1

Hugo ID 10840
Name Shc1
Description src homology 2 domain-containing transforming protein C1
Notes mouse homolog interacts with growth factor receptors; involved in transformation and differentiation in a Ras-dependent fashion [RGD]
Owner Public
URN urn:agi-llid:6464
Connectivity 991

Source Curated
ResNet
GO component

GenBank ID NC_000001
NM_003029
NP_003020
NM_183001
NP_892113
NT_004487
NW_925683
AC_000044
AF455141
AAM61859
AAM61860
AL451085
CAI13246
CAI13247
CAI13248
CAI13249
CAI13250
CAI13251
CAI13252
CAI13253
CAI13254
Y09847
CAA70977
AB208849
BAD92086
AK096169
AK130014
BC011813
BC014158
AAH14158
BC017283
BC033925
AAH33925
BX647136
BX647149
U73377
AAB49972
X68148
CAA48251
P29353
Q59HB0
Q5T180
Q5T181
Q5T182
Q5T183
Q5T184
Q5T185
Q5T186
Q5T187
Q5T188
Q8NFT0
Q8NFT1
NC_000069
NM_011368
NP_035498
NT_039240
NW_000191
NW_001030721
AC_000025
AC171273
AF455140
U46956
AAA91777
AI050321
AK036980
AK049357
BAC33706
AK155158
BAE33083
AK191292
AK195313
AK199216
AK203451
AK205229
AK211173
BB753533
BC036172
AAH36172
BG070010
BG082870
BG088317
U15784
AAC52146
P98083
NC_005101
NM_053517
NP_445969
NW_001084805
NW_047626
AC_000070
BC088298
AAH88298
D83015
BAA74950
Q5M824
Q9Z1I0
119573555
119573556
15559595
17380299
1834515
1899055
21541500
21541501
21706900
36454
55960108
55960109
55960110
55960111
55960112
55960113
55960114
55960115
55960116
62087278
74707598
74730298
74730299
74744423
74744424
74744425
74744426
74744427
74744428
74744429
74744430
74744431
AK225332
CH471121
EAW53170
EAW53171
14211984
21264509
23273601
26340086
558999
74196394
4249548
56789497
81870081
81883074
XM_342282
NT_039234
NT_086596
XP_342283
113912120
122143183
122144089
71725061
AAI22689
AAZ38953
BC122688
DQ125497
NC_007301
NM_001075305
NP_001068773
NW_001494724
Q0IIE2
Q45KX9
119573552
119573553
119573554
EAW53167
EAW53168
EAW53169
148683248
148683249
AK194449
CH466547
EDL15195
EDL15196
149048050
149048051
149048052
CH473976
EDM00626
EDM00627
EDM00628

LocusLink ID 6464
20416
85385
507196

Organism Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus

OMIM ID 600560

Alias SHC
p66
SHCA
p52SHC
p66SHC
FLJ26504
SHC (Src homology 2 domain containing) transforming protein 1
SHC (Src homology 2 domain-containing) transforming protein 1
src homology 2 domain-containing transforming protein C
src homology 2 domain-containing transforming protein C1
P(66)
hypothetical protein 6720466E06
Shc1
(Src homology 2 domain-containing) transforming 1
(Src homology 2 domain-containing) transforming I
Sck (Rattus rattus)
SHC (Src homology 2 domain-containing) transforming protein I
Shc I
Shc-P
6720466E06
SHC transforming protein

GO ID 0005158
0005159
0005543
0005515
0005068
0000187
0007242
0008284
0045840
0001558
0007176
0005886
0030036
0048661
0001784
0005737
0005739
0001525
0007507
0016337
0031532
0051219

Swiss-Prot Accession P29353
Q59HB0
Q5T180
Q5T181
Q5T182
Q5T183
Q5T184
Q5T185
Q5T186
Q5T187
Q5T188
Q8NFT0
Q8NFT1
P98083
Q5M824
Q9Z1I0

Unigene ID Hs.433795
Mm.86595
Rn.138818
Bt.4279

RGD ID 620446

MGI ID 98296

Cell Localization Cytoplasm

Pathway HGF
Insulin Receptor Signaling
Neurotensin
Antiapoptotic Pathways From IGF-1R
Insulin pathway
EGF signaling
EPHB1
PDGFRB
p38 Signaling
PDGF signaling
opioids OPRD1
MAPK-ERK in Growth and Differentiation
Erythropoietin signaling
IL-6 signaling
G-protein Coupled Receptor signaling
Bombesin
Oxytocin
PTEN signaling
SAPK-JNK Signaling
IL-3 signaling
Vasopressin
IL-2 signaling
Cholecystokinin
Gastrin
Substance P
NGF signaling
Erk-PI3K in Collagen Binding
Endothelin
IL-1 and IL-6 signaling
EGF
Integrin Signaling
Nociceptin
EDG2 -> ELK4-SRF signaling pathway
EGFR -> AP-1 signaling pathway
NTRK1 -> SMAD3 signaling pathway
NTRKs -> AP-1 signaling pathway
NTRKs -> CREB1 signaling pathway
NTRKs -> ELK1-SRF signaling pathway
NTRKs -> ELK4-SRF signaling pathway
ERBB2 -> ETV4 signaling pathway
EGFR -> ATF2 signaling pathway
EGFR -> CTNND1 signaling pathway
EGFR -> SMAD1 signaling pathway
NTRKs -> MYC signaling pathway
NTRKs -> STAT5A signaling pathway
EGFR/ERBB2 -> CTNNB1 signaling pathway
NTRKs -> TP53 signaling pathway
IGF1R -> ELK1-SRF signaling pathway
EGFR/ERBB2 -> HIF1A signaling pathway
ERBB2/3 -> SP1 signaling pathway
IGF1R -> ELK4-SRF signaling pathway
IGF1R -> HIF1A signaling pathway
IGF1R -> MYC signaling pathway
IGF1R -> SREBF1 signaling pathway
EGFR/ERBB2 -> TP53 signaling pathway
F2R -> AP-1 signaling pathway
EGFR/ERBB4 -> STAT5A signaling pathway
EGFR/ERBB4 -> STAT5B signaling pathway
PLAUR -> ELK1-SRF signaling pathway
RET -> HSF1 signaling pathway
PLAUR -> ELK4-SRF signaling pathway
F2R -> CREB1 signaling pathway
F2R -> ELK1-SRF signaling pathway
F2R -> ELK4-SRF signaling pathway
F2R -> SP1 signaling pathway
EPOR -> FOS signaling pathway
FCGR3A -> ELK1-SRF signaling pathway
FCGR3A -> ELK4-SRF signaling pathway
ERBB2 -> EP300 signaling pathway
ERBB2 -> ETS1 signaling pathway
ERBB2 -> ETS2 signaling pathway
ERBB2 -> ETV1 signaling pathway
IL2R -> ELK1-SRF signaling pathway
IL2R -> ELK4-SRF signaling pathway
IL2R -> MYC signaling pathway
IL4R -> ELK1-SRF signaling pathway
IL4R -> ELK4-SRF signaling pathway
IL4R -> HMGY signaling pathway
FGFRs -> RUNX2 signaling pathway
INSR -> ELK1-SRF signaling pathway
INSR -> ELK4-SRF signaling pathway
INSR -> SREBF1 signaling pathway
INSR -> SREBF2 signaling pathway
ITGB1 -> AP-1 signaling pathway
ITGB1 -> ELK1-SRF signaling pathway
ITGB1 -> ELK4-SRF signaling pathway
ITGB1 -> SREBF1 signaling pathway
ITGB1 -> SREBF2 signaling pathway
KDR -> ATF1 signaling pathway
GFRs -> AP-1 signaling pathway
GFRs -> CREB1 signaling pathway
GFRs -> CREBBP signaling pathway
GFRs -> ELK1-SRF signaling pathway
KDR -> ATF2 signaling pathway
GFRs -> ELK4-SRF signaling pathway
KDR -> CREB1 signaling pathway
CHRM1 -> CREB1 signaling pathway
GFRs -> MYC signaling pathway
GFRs -> NCOR2 signaling pathway
KDR -> ELK1-SRF signaling pathway
KDR -> ELK4-SRF signaling pathway
KDR -> NFATC1 signaling pathway
KIT -> MITF signaling pathway
GHR -> ELK1-SRF signaling pathway
CHRM1 -> ELK1-SRF signaling pathway
CHRM1 -> ELK4-SRF signaling pathway
GHR -> ELK4-SRF signaling pathway
GHR -> MYC signaling pathway
GRM1/5 -> CREB1 signaling pathway
MPL -> CREB1 signaling pathway
MPL -> SP1 signaling pathway
MPL -> SPI1 signaling pathway
DDR1 -> NF-kB signaling pathway
DRD2 -> AP-1 signaling pathway
DRD2 -> CREB1 signaling pathway
DRD2 -> ELK1-SRF signaling pathway
DRD2 -> ELK4-SRF signaling pathway
EDG2 -> ELK1-SRF signaling pathway
insulin signaling pathway
insulin signaling pathway
scatter factor-hepatocyte growth factor signaling pathway

Group Ph
Sh2
intracellular signaling cascade
regulation of epidermal growth factor receptor activity
activation of MAPK activity
positive regulation of mitosis
regulation of cell growth
actin cytoskeleton organization and biogenesis
positive regulation of cell proliferation
positive regulation of smooth muscle cell proliferation
plasma membrane
protein binding
phospholipid binding
insulin receptor binding
insulin-like growth factor receptor binding
transmembrane receptor protein tyrosine kinase adaptor protein activity

Homo sapiens Chromosome position 1q21

Mouse chromosome position 3 45.0 cM

Microarray ID 104350_at
93713_at
201469_s_at

GO Molecular Function protein binding
phospholipid binding
insulin receptor binding
insulin-like growth factor receptor binding
transmembrane receptor protein tyrosine kinase ada

Rat chromosome position 2q34

Human chromosome position 1q21

FunctionalClass insulin receptor binding
insulin-like growth factor receptor binding
phospholipid binding
protein binding
transmembrane receptor protein tyrosine kinase adaptor protein
phosphotyrosine binding
phosphoprotein binding

GO Biological Process intracellular signaling cascade
regulation of epidermal growth factor receptor act
activation of MAPK activity
positive regulation of mitosis
regulation of cell growth
actin cytoskeleton organization and biogenesis
positive regulation of cell proliferation
positive regulation of smooth muscle cell prolifer
activation of MAPK
regulation of epidermal growth factor receptor
actin cytoskeleton reorganization
angiogenesis
cell-cell adhesion
heart development

GO Cellular Component plasma membrane
cytoplasm
mitochondrion

Bos taurus Chromosome position 3

Mus musculus Chromosome position 3 45.0 cM

MedScan ID 6464

MedLine Reference 10037694
10086341
10382761
10457218
10477722
10482988
10559276
10570290
10602027
10623845
10650943
10652211
10662798
10704825
10748054
10749680
10764799
10783152
10790433
10816433
10896916
10921922
10971656
10996427
11027663
11044453
11075717
11094073
11302736
11505033
11607835
11694516
11707390
11707404
11707405
11714803
11724572
11773443
11855827
11877420
11884411
11884620
11896612
11903040
11948181
11950700
11980671
12009895
12024011
12048194
12069755
12237775
12400011
12446583
12477932
12577067
12586295
12589038
12789267
14530863
14665640
14676841
14702039
14749389
14764897
14983012
14990987
15094067
15226408
15308584
15316024
15485499
15562031
15688026
15705774
15753984
15888547
15992607
16170380
16186108
1623525
16257509
16481327
16487929
16519809
16756945
16825188
16934220
17081113
7499194
7514169
7524086
7535773
7537849
7541035
7541045
7544443
7556090
7559478
7635484
7650013
7675451
7731718
7791787
7806213
7929214
7933095
7961936
8035825
8183561
8195171
8226808
8294403
8400282
8491186
8557643
8617812
8628261
8643566
8656061
8662748
8662998
8761298
8776723
8918464
8940017
9045663
9047384
9049300
9058724
9083103
9096689
9121430
9126968
9174053
9209414
9223670
9325171
9344843
9346925
9373149
9378963
9388490
9446569
9544989
9614102
9632636
9659899
9660833
9685404
9694850
9710204
9710588
9741627
9824671
9872323
9927207
10349636
10580504
10797480
10809671
10922068
11042159
11076861
11088019
11163269
11217851
11409899
11756549
11831027
11884717
12032825
12052829
12101399
12466851
12571362
12808090
12842895
14502564
14576154
14698815
14698816
15102471
15121188
15173034
15505103
15621204
15716419
15782199
15837797
15899871
15998704
16141072
16141073
16251354
16400024
16517240
16520382
16614081
16731826
16829231
16870734
16972253
17272725
7798194
8887653
9346957
12837289
12882334
15262993
9271418
9920808
12522270
14573619
15489334
15592455
15951569
17081983
17158237
17167775
17380301
7473762
7544002
8125298
8524391
8939605
9192859
9233773
16763167
16809014
16963224
16982683
17077388
17219406
17360381
17417601
17626887
9165038
13679576
1409579
17274988
8910399
9748281

Rattus norvegicus Chromosome position 2q34