Protein Nr3c1

URN	urn:agi-llid:2908
Connectivity	1149
Name	Nr3c1
Description	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Notes	The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq]

Pathway	SerotoninR4/6/7 -> NR3C signaling
	cortisol signaling pathway

GO Molecular Function	transcription regulator activity
	chromatin binding
	lipid binding
	transcription activator activity
	transcription factor activity
	protein complex binding
	heat shock protein binding
	steroid binding
	DNA binding
	protein homodimerization activity
	NF-kappaB binding
	receptor tyrosine kinase binding
	protein heterodimerization activity
	sequence-specific DNA binding
	double-stranded DNA binding
	metal ion binding
	zinc ion binding
	receptor activity
	ligand-dependent nuclear receptor activity
	steroid hormone receptor activity
	glucocorticoid receptor activity

GO Biological Process	regulation of cell proliferation
	adrenal gland development
	mammary gland duct morphogenesis
	signal transduction
	negative regulation of transforming growth factor beta receptor signaling pathway
	regulation of gluconeogenesis
	regulation of glucocorticoid biosynthetic process
	regulation of transcription
	chromatin-mediated maintenance of transcription
	regulation of transcription, DNA-dependent
	positive regulation of neuron apoptosis
	anti-apoptosis
	glucocorticoid metabolic process
	transcription
	transcription, DNA-dependent
	transcription from RNA polymerase II promoter
	chromatin modification
	chromatin remodeling
	response to arsenic
	response to protein stimulus
	glucocorticoid receptor signaling pathway

Ariadne Ontology	Estrogen-like

Group	Estrogen-like
	transcription regulator activity
	regulation of cell proliferation
	adrenal gland development
	mammary gland duct morphogenesis
	signal transduction
	negative regulation of transforming growth factor beta receptor signaling pathway
	regulation of gluconeogenesis
	regulation of glucocorticoid biosynthetic process
	regulation of transcription
	chromatin-mediated maintenance of transcription
	regulation of transcription, DNA-dependent
	positive regulation of neuron apoptosis
	anti-apoptosis
	glucocorticoid metabolic process
	transcription
	transcription, DNA-dependent
	transcription from RNA polymerase II promoter
	chromatin modification
	chromatin remodeling
	response to arsenic
	response to protein stimulus
	glucocorticoid receptor signaling pathway
	chromatin binding
	lipid binding
	transcription activator activity
	transcription factor activity
	protein complex binding
	heat shock protein binding
	steroid binding
	DNA binding
	protein homodimerization activity
	NF-kappaB binding
	receptor tyrosine kinase binding
	protein heterodimerization activity
	sequence-specific DNA binding
	double-stranded DNA binding
	metal ion binding
	zinc ion binding
	receptor activity
	ligand-dependent nuclear receptor activity
	steroid hormone receptor activity
	glucocorticoid receptor activity
	protein complex
	membrane
	intracellular
	cytoplasm
	cytosol
	mitochondrial matrix
	nucleolus
	nucleus

MedScan ID	2908

Hugo ID	7978

Human chromosome position	5q31.3

Alias	GR
	GCR
	GRL
	GCCR
	glucocorticoid receptor
	OTTHUMP00000222854
	nuclear receptor subfamily 3 group C member 1
	Grl1
	Grl-1
	OTTMUSP00000028420
	OTTMUSP00000028421
	OTTMUSP00000028423
	glucocorticoid receptor 1
	GCR_HUMAN
	glucocorticoid receptor I
	glucocorticoid receptor, alpha splice form
	Glucocorticoid receptor, lymphocyte
	Gralpha
	Grl I
	LOC389335
	Nr3c I
	NR3C1
	nuclear receptor subfamily 3, group C, member 1
	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
	nuclear receptor subfamily 3, group C, member I

OMIM ID	138040

Mouse chromosome position	18 20.0 cM

Rat chromosome position	18p12

Cell Localization	Cytoplasm
	Nucleus

Homologene ID	30960

RGD ID	2741

MGI ID	95824