Ariadne Genomics Inc. stress conditions Nr3c1 target genes Nr3c1 coactivators Nr3c1 corepressors Nr3c1 chaperones cortisol Nr3c1 ---- Nr3c1 chaperones translocated Nr3c1 complex ---> Nr3c1 target genes translocated Nr3c1 complex ---| HPA axis HPA axis HPA axis --+> cortisol biosynthetic pathway cortisol ---- Nr3c1 Nr3c1 Nr3c1 corepressors ---- translocated Nr3c1 complex Nr3c1 coactivators --+> translocated Nr3c1 complex Nr3c1 ---> translocated Nr3c1 complex Nr3c1 corepressors ---| translocated Nr3c1 complex Nr3c1 coactivators ---- translocated Nr3c1 complex direct and indirect target gene expression cortisol biosynthetic pathway translocated Nr3c1 complex stress conditions --+> HPA axis translocated Nr3c1 complex ---> Nr3c1 target genes