| URN | urn:agi-llid:3291 |
|---|---|
| Connectivity | 188 |
| Name | Hsd11b2 |
| Description | hydroxysteroid (11-beta) dehydrogenase 2 |
| Notes | There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq] |
| Pathway | aldosterone signaling pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| oxidoreductase activity | |
| NAD or NADH binding | |
| steroid binding | |
| 11-beta-hydroxysteroid dehydrogenase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| endoplasmic reticulum | |
| microsome |
| GO Biological Process | metabolic process |
|---|---|
| female pregnancy | |
| oxidation reduction | |
| response to stress | |
| regulation of blood volume by renal aldosterone | |
| glucocorticoid metabolic process | |
| glucocorticoid biosynthetic process | |
| response to drug | |
| response to food | |
| response to hypoxia | |
| response to steroid hormone stimulus | |
| response to insulin stimulus | |
| response to glucocorticoid stimulus |
| Ariadne Ontology | Steroid metabolism |
|---|
| Group | Steroid metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| female pregnancy | |
| oxidation reduction | |
| response to stress | |
| regulation of blood volume by renal aldosterone | |
| glucocorticoid metabolic process | |
| glucocorticoid biosynthetic process | |
| response to drug | |
| response to food | |
| response to hypoxia | |
| response to steroid hormone stimulus | |
| response to insulin stimulus | |
| response to glucocorticoid stimulus | |
| oxidoreductase activity | |
| NAD or NADH binding | |
| steroid binding | |
| 11-beta-hydroxysteroid dehydrogenase activity | |
| cytoplasm | |
| endoplasmic reticulum | |
| microsome |
| MedScan ID | 3291 |
|---|
| Hugo ID | 5209 |
|---|
| Human chromosome position | 16q22 |
|---|
| LocusLink ID | 3291 |
|---|---|
| 15484 | |
| 25117 |
| Alias | AME |
|---|---|
| AME1 | |
| HSD2 | |
| HSD11K | |
| SDR9C3 | |
| corticosteroid 11-beta-dehydrogenase isozyme 2 | |
| 11-DH2 | |
| 11-beta-HSD2 | |
| 11-beta-hydroxysteroid dehydrogenase type 2 | |
| NAD-dependent 11-beta-hydroxysteroid dehydrogenase | |
| short chain dehydrogenase/reductase family 9C member 3 | |
| 11HSD2 | |
| 11(beta)-HSD2 | |
| MGC93528 | |
| Hydroxysteroid dehydrogenase, 11 beta type 2 | |
| 11- DH2 | |
| 11-beta-hydroxysteroid dehydrogenase 2 | |
| 11-beta-hydroxysteroid dehydrogenase II | |
| AME I | |
| Corticosteroid 11-beta-dehydrogenase, isozyme 2 | |
| Corticosteroid 11-beta-dehydrogenase, isozyme II | |
| HSD11B2 | |
| hydroxysteroid (11-beta) dehydrogenase 2 | |
| hydroxysteroid (11-beta) dehydrogenase II | |
| Hydroxysteroid dehydrogenase, 11 beta type II | |
| NAD- dependent 11-beta-hydroxysteroid dehydrogenase 2 | |
| NAD- dependent 11-beta-hydroxysteroid dehydrogenase II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 218030 |
|---|
| Mouse chromosome position | 8 50.8 cM |
|---|
| GO ID | 0003845 |
|---|---|
| 0051287 | |
| 0016491 | |
| 0005496 | |
| 0007565 | |
| 0006704 | |
| 0055114 | |
| 0002017 | |
| 0042493 | |
| 0032094 | |
| 0051384 | |
| 0001666 | |
| 0032868 | |
| 0048545 | |
| 0005737 | |
| 0005783 | |
| 0005792 | |
| 0003824 | |
| 0008211 | |
| 0008152 | |
| 0006950 |
| Rat chromosome position | 19q11-q12 |
|---|
| Swiss-Prot Accession | P80365 |
|---|---|
| P51661 | |
| Q6NZB9 | |
| Q3U2R0 | |
| P50233 | |
| Q58F95 | |
| A7LB28 | |
| C5HTY7 | |
| Q13194 | |
| Q6P2G9 | |
| Q8N439 | |
| Q96QN8 | |
| Q9UC50 | |
| Q9UC51 | |
| Q9UCW5 | |
| Q9UCW6 | |
| Q9UCW7 | |
| Q9UCW8 | |
| Q91WK3 |
| PIR ID | S62789 |
|---|---|
| S60188 |
| Unigene ID | Hs.1376 |
|---|---|
| Mm.5079 | |
| Rn.10186 |
| KEGG ID | hsa:3291 |
|---|---|
| mmu:15484 | |
| rno:25117 |
| EC Number | 1.1.1.146 |
|---|---|
| 1.1.1.- |
| Swiss-Prot ID | DHI2_HUMAN |
|---|---|
| DHI2_RAT | |
| DHI2_MOUSE | |
| Q6NZB9_MOUSE |
| Cell Localization | Microsome |
|---|---|
| Endoplasmic reticulum | |
| Mitochondria |
| IPI ID | IPI00300050 |
|---|---|
| IPI00196451 | |
| IPI00125121 |
| Homologene ID | 20088 |
|---|
| RGD ID | 2835 |
|---|
| MGI ID | 104720 |
|---|