| URN | urn:agi-llid:10724 |
|---|---|
| Connectivity | 48 |
| Name | Mgea5 |
| Description | meningioma expressed antigen 5 (hyaluronidase) |
| Notes | The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM] |
| Pathway | hexosamine biosynthetic pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| transferase activity | |
| hydrolase activity, acting on glycosyl bonds | |
| acyltransferase activity | |
| histone acetyltransferase activity | |
| beta-N-acetylhexosaminidase activity | |
| hyalurononglucosaminidase activity | |
| beta-N-acetylglucosaminidase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| mitochondrion | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| aging | |
| positive regulation of cell killing | |
| negative regulation of cardiac muscle adaptation | |
| necrotic cell death | |
| positive regulation of mitochondrial depolarization | |
| positive regulation of calcium ion transport into cytosol | |
| positive regulation of insulin secretion | |
| positive regulation of growth hormone secretion | |
| negative regulation of protein amino acid glycosylation | |
| positive regulation of proteolysis | |
| positive regulation of DNA metabolic process | |
| dATP metabolic process | |
| N-acetylglucosamine metabolic process | |
| glycoprotein catabolic process | |
| response to steroid hormone stimulus | |
| positive regulation of protein complex disassembly | |
| positive regulation of calcium ion transport | |
| positive regulation of glucose import | |
| protein targeting to membrane |
| Ariadne Ontology | Glycan catabolism |
|---|
| Group | Glycan catabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| aging | |
| positive regulation of cell killing | |
| negative regulation of cardiac muscle adaptation | |
| necrotic cell death | |
| positive regulation of mitochondrial depolarization | |
| positive regulation of calcium ion transport into cytosol | |
| positive regulation of insulin secretion | |
| positive regulation of growth hormone secretion | |
| negative regulation of protein amino acid glycosylation | |
| positive regulation of proteolysis | |
| positive regulation of DNA metabolic process | |
| dATP metabolic process | |
| N-acetylglucosamine metabolic process | |
| glycoprotein catabolic process | |
| response to steroid hormone stimulus | |
| positive regulation of protein complex disassembly | |
| positive regulation of calcium ion transport | |
| positive regulation of glucose import | |
| protein targeting to membrane | |
| hydrolase activity | |
| transferase activity | |
| hydrolase activity, acting on glycosyl bonds | |
| acyltransferase activity | |
| histone acetyltransferase activity | |
| beta-N-acetylhexosaminidase activity | |
| hyalurononglucosaminidase activity | |
| beta-N-acetylglucosaminidase activity | |
| cytoplasm | |
| mitochondrion | |
| nucleus |
| MedScan ID | 10724 |
|---|
| Hugo ID | 7056 |
|---|
| Human chromosome position | 10q24.1-q24.3 |
|---|
| LocusLink ID | 10724 |
|---|---|
| 76055 | |
| 154968 |
| Alias | OGA |
|---|---|
| MEA5 | |
| NCOAT | |
| FLJ11229 | |
| FLJ23355 | |
| KIAA0679 | |
| bifunctional protein NCOAT | |
| O-GlcNAcase | |
| hyaluronidase in meningioma | |
| meningioma-expressed antigen 5 | |
| nuclear cytoplasmic O-GlcNAcase and acetyltransferase | |
| Hy5 | |
| AA408215 | |
| mKIAA0679 | |
| 2810009A20Rik | |
| 4833427O07Rik | |
| 5830447M11Rik | |
| 2810009A20 | |
| 4833427O07 | |
| 5830447M11 | |
| meningioma expressed antigen 5 | |
| meningioma expressed antigen 5 (hyaluronidase) | |
| MGEA5 | |
| O-GlcNAc hydrolase | |
| OTTHUMP00000020345 | |
| RIKEN cDNA 2810009A20 gene | |
| RIKEN cDNA 4833427O07 gene | |
| HY 5 | |
| HY(5) | |
| HY-5 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604039 |
|---|
| Mouse chromosome position | 19 45.1 cM |
|---|
| GO ID | 0008415 |
|---|---|
| 0004563 | |
| 0004402 | |
| 0004415 | |
| 0016798 | |
| 0016740 | |
| 0006044 | |
| 0007568 | |
| 0046060 | |
| 0006516 | |
| 0008152 | |
| 0070265 | |
| 0010616 | |
| 0060051 | |
| 0051054 | |
| 0010524 | |
| 0031343 | |
| 0046326 | |
| 0060124 | |
| 0032024 | |
| 0051901 | |
| 0043243 | |
| 0045862 | |
| 0006612 | |
| 0048545 | |
| 0005737 | |
| 0005634 | |
| 0003824 | |
| 0016787 | |
| 0051928 | |
| 0016231 | |
| 0005739 |
| Rat chromosome position | 1q54 |
|---|
| Swiss-Prot Accession | O60502 |
|---|---|
| Q9EQQ9 | |
| Q05CX1 | |
| Q9CU60 | |
| Q8VIJ5 | |
| B7WPB9 | |
| O75166 | |
| Q86WV0 | |
| Q8IV98 | |
| Q9BVA5 | |
| Q9HAR0 | |
| Q3ULY7 | |
| Q6ZQ71 | |
| Q8BK05 | |
| Q8BTT2 | |
| Q8CFX2 | |
| Q9CSJ4 | |
| Q9CUR7 | |
| D3DR79 |
| PIR ID | T00360 |
|---|
| Unigene ID | Hs.500842 |
|---|---|
| Mm.393213 | |
| Mm.440640 | |
| Mm.478844 | |
| Rn.162539 | |
| Mm.122725 |
| KEGG ID | hsa:10724 |
|---|---|
| mmu:76055 | |
| rno:154968 |
| EC Number | 3.2.1.52 |
|---|---|
| 2.3.1.48 |
| Swiss-Prot ID | NCOAT_HUMAN |
|---|---|
| NCOAT_MOUSE | |
| NCOAT_RAT | |
| D3DR79_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Extracellular |
| IPI ID | IPI00465449 |
|---|---|
| IPI00477231 | |
| IPI00941608 | |
| IPI00406624 | |
| IPI00655175 | |
| IPI00788404 | |
| IPI00208152 | |
| IPI00778199 | |
| IPI00786819 | |
| IPI00181391 | |
| IPI00640090 | |
| IPI00786809 | |
| IPI00391457 |
| Homologene ID | 8154 |
|---|
| RGD ID | 621077 |
|---|
| MGI ID | 1932139 |
|---|