| URN | urn:agi-llid:8473 |
|---|---|
| Connectivity | 87 |
| Name | Ogt |
| Description | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) |
| Notes | O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Pathway | hexosamine biosynthetic pathway |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| peptide binding | |
| transferase activity | |
| monosaccharide binding | |
| transferase activity, transferring glycosyl groups | |
| acetylglucosaminyltransferase activity | |
| protein N-acetylglucosaminyltransferase activity | |
| N-acetyltransferase activity |
| GO Cellular Component | intracellular |
|---|---|
| cytoplasm | |
| cytosol | |
| MLL5-L complex | |
| nucleus |
| GO Biological Process | signal transduction |
|---|---|
| protein amino acid O-linked glycosylation | |
| response to nutrient | |
| protein homotrimerization |
| Ariadne Ontology | Glycosylation in Golgi |
|---|---|
| Glucose metabolism |
| Group | Glycosylation in Golgi |
|---|---|
| Glucose metabolism | |
| catalytic activity | |
| signal transduction | |
| protein amino acid O-linked glycosylation | |
| response to nutrient | |
| protein homotrimerization | |
| peptide binding | |
| transferase activity | |
| monosaccharide binding | |
| transferase activity, transferring glycosyl groups | |
| acetylglucosaminyltransferase activity | |
| protein N-acetylglucosaminyltransferase activity | |
| N-acetyltransferase activity | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| MLL5-L complex | |
| nucleus |
| MedScan ID | 8473 |
|---|
| Hugo ID | 8127 |
|---|
| Human chromosome position | Xq13 |
|---|
| LocusLink ID | 8473 |
|---|---|
| 108155 | |
| 26295 |
| Alias | HRNT1 |
|---|---|
| FLJ23071 | |
| MGC22921 | |
| O-GLCNAC | |
| UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | |
| O-GlcNAc transferase p110 subunit | |
| O-GlcNAc transferase subunit p110 | |
| O-linked N-acetylglucosamine transferase 110 kDa subunit | |
| uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase | |
| Ogtl | |
| AI115525 | |
| 1110038P24Rik | |
| 4831420N21Rik | |
| RP23-49C8.1 | |
| OTTMUSP00000019750 | |
| O-linked GlcNAc transferase | |
| UDP-N-acetylglucosaminyltransferase | |
| O linked N-acetylglucosamine transferase like | |
| O linked N-acetylglucosamine transferase | |
| UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase | |
| 1110038P24 | |
| 4831420N21 | |
| LOC212707 | |
| O linked N-acetylgulucosamine transferase like | |
| O-GLCNAC transferase | |
| O-GlcNAc transferase P100 subunit | |
| OGT | |
| O-linked N-acetylglucosamine (GlcNAc) transferase | |
| O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine: | |
| O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | |
| OTTHUMP00000032154 | |
| OTTHUMP00000032166 | |
| UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 100 kDa | |
| uridine diphospho-N-acetylglucosamine:polypeptide beta | |
| uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl | |
| O-linked N-acetylglucosamine transferase | |
| RIKEN cDNA 4831420N21 gene | |
| UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | |
| RIKEN cDNA 1110038P24 gene | |
| ncoat | |
| nuclear cytoplasmic o-glcnacase and acetyltransferase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 300255 |
|---|
| Mouse chromosome position | X |
|---|---|
| X D |
| GO ID | 0008375 |
|---|---|
| 0048029 | |
| 0042277 | |
| 0016262 | |
| 0016757 | |
| 0006493 | |
| 0070207 | |
| 0007584 | |
| 0007165 | |
| 0070688 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0008080 | |
| 0003824 | |
| 0016740 | |
| 0005622 | |
| 0005515 | |
| 0005488 |
| Rat chromosome position | Xq31 |
|---|
| Swiss-Prot Accession | O15294 |
|---|---|
| Q548W1 | |
| Q9H5T3 | |
| Q8CGY8 | |
| Q3TQV0 | |
| Q80XU6 | |
| Q8C676 | |
| P56558 | |
| Q7Z3K0 | |
| Q8WWM8 | |
| Q96CC1 | |
| Q9UG57 | |
| A2ALY1 | |
| Q6PG10 | |
| Q8BXH6 | |
| Q91Y38 |
| PIR ID | T31673 |
|---|
| Unigene ID | Hs.405410 |
|---|---|
| Mm.259191 | |
| Rn.82705 | |
| Mm.474838 |
| KEGG ID | hsa:8473 |
|---|---|
| mmu:108155 | |
| rno:26295 |
| EC Number | 2.4.1.- |
|---|
| Swiss-Prot ID | OGT1_HUMAN |
|---|---|
| OGT1_RAT | |
| OGT1_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Golgi |
| IPI ID | IPI00005780 |
|---|---|
| IPI00219856 | |
| IPI00607723 | |
| IPI00231503 | |
| IPI00420870 | |
| IPI00845528 |
| Homologene ID | 9675 |
|---|
| RGD ID | 62060 |
|---|
| MGI ID | 1339639 |
|---|