| URN | urn:agi-llid:2673 |
|---|---|
| Connectivity | 57 |
| Name | Gfpt1 |
| Description | glutamine-fructose-6-phosphate transaminase 1 |
| Notes | Glutamine-fructose-6-phosphate transaminase 1 is the first and rate-limiting enzyme of the hexosamine pathway. GFAT controls the flux of glucose into the hexosamine pathway and catalyzes the formation of glucosamine 6-phosphate. |
| Pathway | hexosamine biosynthetic pathway |
|---|
| GO Molecular Function | transferase activity |
|---|---|
| amino acid binding | |
| sugar binding | |
| transaminase activity | |
| glutamine-fructose-6-phosphate transaminase (isomerizing) activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm |
| GO Biological Process | metabolic process |
|---|---|
| chondrocyte development | |
| melanocyte differentiation | |
| embryonic viscerocranium morphogenesis | |
| negative regulation of glycogen biosynthetic process | |
| glucosamine biosynthetic process | |
| fructose 6-phosphate metabolic process | |
| UDP-N-acetylglucosamine metabolic process | |
| glutamine metabolic process | |
| energy reserve metabolic process | |
| cellular response to insulin stimulus | |
| response to insulin stimulus | |
| response to sucrose stimulus | |
| protein homotetramerization | |
| carbohydrate metabolic process | |
| carbohydrate biosynthetic process |
| Ariadne Ontology | Amino sugars synthesis |
|---|
| Group | Amino sugars synthesis |
|---|---|
| metabolic process | |
| chondrocyte development | |
| melanocyte differentiation | |
| embryonic viscerocranium morphogenesis | |
| negative regulation of glycogen biosynthetic process | |
| glucosamine biosynthetic process | |
| fructose 6-phosphate metabolic process | |
| UDP-N-acetylglucosamine metabolic process | |
| glutamine metabolic process | |
| energy reserve metabolic process | |
| cellular response to insulin stimulus | |
| response to insulin stimulus | |
| response to sucrose stimulus | |
| protein homotetramerization | |
| carbohydrate metabolic process | |
| carbohydrate biosynthetic process | |
| transferase activity | |
| amino acid binding | |
| sugar binding | |
| transaminase activity | |
| glutamine-fructose-6-phosphate transaminase (isomerizing) activity | |
| soluble fraction | |
| cytoplasm |
| MedScan ID | 2673 |
|---|
| Hugo ID | 4241 |
|---|
| Human chromosome position | 2p13 |
|---|
| LocusLink ID | 2673 |
|---|---|
| 14583 | |
| 297417 |
| Alias | GFA |
|---|---|
| GFAT | |
| GFPT | |
| GFAT1 | |
| GFAT 1 | |
| GFAT1m | |
| glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 | |
| hexosephosphate aminotransferase 1 | |
| D-fructose-6-phosphate amidotransferase 1 | |
| glutamine-fructose-6-phosphate transaminase 1 | |
| glutamine:fructose 6 phosphate amidotransferase 1 | |
| glutamine: fructose-6-phosphate amidotransferase-1 | |
| AI324119 | |
| AI449986 | |
| 2810423A18Rik | |
| OTTMUSP00000026384 | |
| glutamine:fructose-6-phosphate amidotransferase 1 | |
| MGC95214 | |
| 2810423A18 | |
| D-fructose-6- phosphate amidotransferase I | |
| EST AI324119 | |
| GFAT I | |
| GFPT I | |
| GFPT1 | |
| glucosamine-fructose-6-phosphate aminotransferase | |
| Glucosamine-fructose-6-phosphate aminotransferase (isomerizing) 1 | |
| Glucosamine-fructose-6-phosphate aminotransferase (isomerizing) I | |
| glucosamine-fructose-6-phosphate aminotransferase 1 | |
| glutamine fructose-6-phosphate transaminase 1 | |
| glutamine fructose-6-phosphate transaminase I | |
| glutamine: fructose-6-phosphate amidotransferase I | |
| Hexosephosphate aminotransferase I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138292 |
|---|
| Mouse chromosome position | 6 35.5 cM |
|---|
| GO ID | 0004360 |
|---|---|
| 0005529 | |
| 0016740 | |
| 0016051 | |
| 0002063 | |
| 0048703 | |
| 0006112 | |
| 0006002 | |
| 0006541 | |
| 0030318 | |
| 0008152 | |
| 0005737 | |
| 0016597 | |
| 0008483 | |
| 0006047 | |
| 0005975 | |
| 0006042 | |
| 0045719 | |
| 0051289 | |
| 0005625 | |
| 0032869 | |
| 0032868 | |
| 0009744 | |
| 0005575 |
| Rat chromosome position | 4q34 |
|---|
| Swiss-Prot Accession | Q06210 |
|---|---|
| Q8WYR5 | |
| P47856 | |
| O88288 | |
| P82808 | |
| Q53QE6 | |
| Q9BXF8 | |
| Q91XG9 | |
| Q99LP7 | |
| Q99MJ4 | |
| Q5XI08 |
| PIR ID | A45055 |
|---|---|
| I53743 |
| Unigene ID | Hs.580300 |
|---|---|
| Mm.19893 | |
| Rn.161844 | |
| Mm.391492 |
| KEGG ID | hsa:2673 |
|---|---|
| mmu:14583 | |
| rno:297417 |
| EC Number | 2.6.1.16 |
|---|
| Swiss-Prot ID | GFPT1_HUMAN |
|---|---|
| GFPT1_MOUSE | |
| GFPT1_RAT |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00217952 |
|---|---|
| IPI00299506 | |
| IPI00406371 | |
| IPI00755549 | |
| IPI00464911 | |
| IPI00474128 | |
| IPI00856468 | |
| IPI00857387 | |
| IPI00190908 |
| Homologene ID | 68220 |
|---|
| RGD ID | 1549703 |
|---|
| MGI ID | 95698 |
|---|