Protein Camkk2

URN	urn:agi-llid:10645
Total Entities	0
Connectivity	152
Name	Camkk2
Description	calcium/calmodulin-dependent protein kinase kinase 2, beta
Notes	The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]

Ariadne Ontology	CAMKK

GO Molecular Function	calmodulin binding
	nucleotide binding
	ATP binding
	calcium ion binding
	transferase activity
	transferase activity, transferring phosphorus-containing groups
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein kinase activator activity
	protein tyrosine kinase activity
	calmodulin-dependent protein kinase activity

GO Cellular Component	intracellular
	cytoplasm

GO Biological Process	MAPK cascade
	calcium-mediated signaling
	positive regulation of transcription, DNA-dependent
	activation of protein kinase activity
	regulation of protein kinase activity
	protein phosphorylation
	protein autophosphorylation
	phosphorylation

Pathway	T-cell receptor -> CREBBP signaling
	EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling
	NeuropeptideYR -> ATF/CREB signaling
	VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling
	VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling
	NPY Expression Targets
	HBEGF/MEF/MYOD Expression Target
	NRG1/MEF/MYOD Expression Targets
	TGFA/MEF/MYOD/NFATC Expression Targets
	AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
	AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
	IL16/ATF/CREB/CREBBP Expression Target
	CD8/ATF/CREB/CREBBP Expression Targets
	CD80/ATF/CREB/CREBBP Expression Targets
	CD86/ATF/CREB/CREBBP Expression Targets
	CD72/CREB/CREBBP Expression Targets
	PDCD1/ATF/CREB/CREBBP Expression Targets
	TCR/CREB/CREBBP/ATF Expression Targets
	adenosine monophosphate-activated protein kinase (AMPK) signaling pathway

Group	CAMKK
	MAPK cascade
	calcium-mediated signaling
	positive regulation of transcription, DNA-dependent
	activation of protein kinase activity
	regulation of protein kinase activity
	protein phosphorylation
	protein autophosphorylation
	phosphorylation
	calmodulin binding
	nucleotide binding
	ATP binding
	calcium ion binding
	transferase activity
	transferase activity, transferring phosphorus-containing groups
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein kinase activator activity
	protein tyrosine kinase activity
	calmodulin-dependent protein kinase activity
	intracellular
	cytoplasm

MedScan ID	10645

Hugo ID	1470

Human chromosome position	12q24.2

Alias	CAMKK
	CAMKKB
	calcium/calmodulin-dependent protein kinase kinase 2
	caM-KK 2
	caM-KK beta
	CAMKK beta protein
	caM-kinase kinase 2
	caM-kinase kinase beta
	calcium/calmodulin-dependent protein kinase beta
	AW061083
	mKIAA0787
	6330570N16Rik
	caMKK 2
	caMKK beta
	calcium/calmodulin-dependent protein kinase kinase beta
	calcium/calmodulin-dependent protein kinase 2 beta
	Ca+/Calmodulin-dependent protein kinase kinase beta (CaM-kinase kinase beta)
	Kiaa0787
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform VI
	Camkk2
	CaM-KKbeta
	LOC121657
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform V
	CAM-KKB
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform IV
	MGC15254
	calcium/calmodulin-dependent protein kinase kinase 2 beta
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform III
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 2
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 3
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 4
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 5
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 6
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform I
	calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 1
	6330570N16

EC Number	2.7.11.17

PIR ID	JC5669
	JE0191

Cell Localization	Cytoplasm

Mouse chromosome position	5

Rat chromosome position	12q16

Homologene ID	32756

MGI ID	2444812

RGD ID	620092

Primary Cell Localization	Cytoplasm