| URN | urn:agi-llid:22843 |
|---|---|
| Total Entities | 0 |
| Connectivity | 22 |
| Name | Ppm1e |
| Description | protein phosphatase, Mg2+/Mn2+ dependent, 1E |
| Notes | This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] |
| Ariadne Ontology | Phosphatases |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| metal ion binding | |
| hydrolase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity |
| GO Cellular Component | nucleolus |
|---|---|
| protein complex | |
| cytoplasm | |
| nucleus |
| GO Biological Process | negative regulation of protein kinase activity |
|---|---|
| positive regulation of stress fiber assembly | |
| protein dephosphorylation | |
| peptidyl-threonine dephosphorylation | |
| cellular response to drug |
| Pathway | adenosine monophosphate-activated protein kinase (AMPK) signaling pathway |
|---|
| Group | Phosphatases |
|---|---|
| negative regulation of protein kinase activity | |
| positive regulation of stress fiber assembly | |
| protein dephosphorylation | |
| peptidyl-threonine dephosphorylation | |
| cellular response to drug | |
| catalytic activity | |
| metal ion binding | |
| hydrolase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| nucleolus | |
| protein complex | |
| cytoplasm | |
| nucleus |
| MedScan ID | 22843 |
|---|
| Hugo ID | 19322 |
|---|
| Human chromosome position | 17q22 |
|---|
| LocusLink ID | 22843 |
|---|---|
| 320472 | |
| 360593 |
| Alias | POPX1 |
|---|---|
| PP2CH | |
| caMKN | |
| CaMKP-N | |
| protein phosphatase 1E | |
| caMKP-nucleus | |
| partner of PIXA | |
| partner of PIX 1 | |
| partner of PIX-alpha | |
| protein phosphatase 1E (PP2C domain containing) | |
| nuclear calmodulin-dependent protein kinase phosphatase | |
| ca(2+)/calmodulin-dependent protein kinase phosphatase N | |
| AW049266 | |
| mKIAA1072 | |
| B930008A12Rik | |
| RP23-209O5.1 | |
| calmodulin-dependent protein kinase phosphatase N | |
| Kiaa1072 | |
| partner of PIX I | |
| POPX I | |
| PPM1E | |
| protein phosphatase, Mg2+/Mn2+ dependent, 1E | |
| protein phophatase 1E | |
| OTTMUSP00000001216 | |
| B930008A12 | |
| DKFZp781f1422 | |
| LOC327991 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Unigene ID | Hs.245044 |
|---|---|
| Mm.341988 | |
| Rn.201345 |
| KEGG ID | hsa:22843 |
|---|---|
| mmu:320472 | |
| rno:360593 |
| Swiss-Prot Accession | A7E2X1 |
|---|---|
| Q8WY54 | |
| B2KGP3 | |
| Q80TL0 | |
| Q80Z30 | |
| Q5SX30 | |
| Q8BGM6 | |
| Q8CB81 |
| EC Number | 3.1.3.16 |
|---|
| GO ID | 0046872 |
|---|---|
| 0004722 | |
| 0035690 | |
| 0006469 | |
| 0035970 | |
| 0051496 | |
| 0005737 | |
| 0005730 | |
| 0005634 | |
| 0043234 | |
| 0003824 | |
| 0016787 | |
| 0004721 | |
| 0006470 |
| Swiss-Prot ID | PPM1E_MOUSE |
|---|---|
| PPM1E_RAT |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00461286 |
|---|---|
| IPI00331925 |
| Mouse chromosome position | 11 |
|---|
| Rat chromosome position | 10q26 |
|---|
| Homologene ID | 22848 |
|---|
| MGI ID | 2444096 |
|---|
| RGD ID | 735028 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|