| URN | urn:agi-llid:9647 |
|---|---|
| Total Entities | 0 |
| Connectivity | 68 |
| Name | Ppm1f |
| Description | protein phosphatase, Mg2+/Mn2+ dependent, 1F |
| Notes | The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Phosphatases |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| metal ion binding | |
| hydrolase activity | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| calmodulin-dependent protein phosphatase activity |
| GO Cellular Component | protein complex |
|---|---|
| perinuclear region of cytoplasm | |
| cytosol |
| GO Biological Process | intrinsic apoptotic signaling pathway |
|---|---|
| negative regulation of transcription, DNA-dependent | |
| negative regulation of peptidyl-serine phosphorylation | |
| negative regulation of protein kinase activity | |
| negative regulation of protein kinase activity by regulation of protein phosphorylation | |
| positive regulation of epithelial cell migration | |
| positive regulation of stress fiber assembly | |
| positive regulation of cell-substrate adhesion | |
| positive regulation of focal adhesion assembly | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| protein dephosphorylation | |
| peptidyl-threonine dephosphorylation | |
| cellular response to drug | |
| apoptotic process | |
| positive regulation of chemotaxis | |
| positive regulation of growth | |
| positive regulation of gene expression |
| Pathway | adenosine monophosphate-activated protein kinase (AMPK) signaling pathway |
|---|
| Group | Phosphatases |
|---|---|
| intrinsic apoptotic signaling pathway | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of peptidyl-serine phosphorylation | |
| negative regulation of protein kinase activity | |
| negative regulation of protein kinase activity by regulation of protein phosphorylation | |
| positive regulation of epithelial cell migration | |
| positive regulation of stress fiber assembly | |
| positive regulation of cell-substrate adhesion | |
| positive regulation of focal adhesion assembly | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| protein dephosphorylation | |
| peptidyl-threonine dephosphorylation | |
| cellular response to drug | |
| apoptotic process | |
| positive regulation of chemotaxis | |
| positive regulation of growth | |
| positive regulation of gene expression | |
| catalytic activity | |
| metal ion binding | |
| hydrolase activity | |
| phosphatase activity | |
| phosphoprotein phosphatase activity | |
| protein serine-threonine phosphatase activity | |
| calmodulin-dependent protein phosphatase activity | |
| protein complex | |
| perinuclear region of cytoplasm | |
| cytosol |
| MedScan ID | 9647 |
|---|
| Hugo ID | 19388 |
|---|
| Human chromosome position | 22q11.22 |
|---|
| LocusLink ID | 9647 |
|---|---|
| 68606 | |
| 287931 |
| Alias | CAMKP |
|---|---|
| FEM-2 | |
| POPX2 | |
| hFEM-2 | |
| CaMKPase | |
| protein phosphatase 1F | |
| PP2C phosphatase | |
| partner of PIX 2 | |
| protein fem-2 homolog | |
| CaM-kinase phosphatase | |
| protein phosphatase 1F (PP2C domain containing) | |
| Ca(2+)/calmodulin-dependent protein kinase phosphatase | |
| mKIAA0015 | |
| 1110021B16Rik | |
| 4933427B07Rik | |
| partner of PIX2 | |
| calcium/calmodulin-dependent protein kinase phosphatase | |
| OTTMUSP00000027985 | |
| KIAA0015 | |
| MGC25978 | |
| OTTHUMP00000198593 | |
| OTTHUMP00000198594 | |
| partner of PIX II | |
| hFEM2 | |
| PPM1F | |
| 1110021B16 | |
| hFEM IIs | |
| protein phosphatase, Mg2+/Mn2+ dependent, 1F | |
| 4933427B07 | |
| Ca(2)/calmodulin-dependent protein kinase phosphatase | |
| camkiipases | |
| FEM II | |
| hFEM II | |
| camkiipase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Unigene ID | Hs.112728 |
|---|---|
| Mm.230296 | |
| Rn.91922 |
| KEGG ID | hsa:9647 |
|---|---|
| mmu:68606 | |
| rno:287931 |
| Swiss-Prot Accession | P49593 |
|---|---|
| Q8CGA0 | |
| B2RYP5 | |
| Q9WVR7 | |
| A8K6G3 | |
| Q96PM2 |
| EC Number | 3.1.3.16 |
|---|
| GO ID | 0033192 |
|---|---|
| 0046872 | |
| 0016791 | |
| 0004722 | |
| 0035690 | |
| 0097193 | |
| 0033137 | |
| 0006469 | |
| 0044387 | |
| 0045892 | |
| 0035970 | |
| 0010811 | |
| 0050921 | |
| 0043280 | |
| 0010634 | |
| 0051894 | |
| 0010628 | |
| 0045927 | |
| 0051496 | |
| 0005829 | |
| 0043234 | |
| 0003824 | |
| 0016787 | |
| 0004721 | |
| 0006915 | |
| 0006470 | |
| 0048471 |
| Swiss-Prot ID | PPM1F_RAT |
|---|---|
| PPM1F_MOUSE | |
| PPM1F_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00205297 |
|---|---|
| IPI00275512 | |
| IPI00291412 |
| Mouse chromosome position | 16 |
|---|
| Rat chromosome position | 11q23 |
|---|
| Homologene ID | 22828 |
|---|
| MGI ID | 1918464 |
|---|
| RGD ID | 631363 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|