Protein Ppp2ca

URN	urn:agi-llid:5515
Total Entities	0
Connectivity	70
Name	Ppp2ca
Description	protein phosphatase 2, catalytic subunit, alpha isozyme
Notes	This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

Ariadne Ontology	PP2A

GO Molecular Function	protein C-terminus binding
	protein heterodimerization activity
	metal ion binding
	hydrolase activity
	phosphoprotein phosphatase activity
	protein serine-threonine phosphatase activity

GO Cellular Component	membrane
	chromosome, centromeric region
	spindle pole
	protein phosphatase type 2A complex
	plasma membrane
	cytoplasm
	mitochondrion
	cytosol
	chromosome
	cytoskeleton
	microtubule cytoskeleton
	nucleus

GO Biological Process	meiosis
	regulation of cell cycle
	regulation of receptor activity
	regulation of Wnt receptor signaling pathway
	negative regulation of tyrosine phosphorylation of Stat3 protein
	inactivation of MAPK activity
	regulation of cell differentiation
	regulation of cell adhesion
	second-messenger-mediated signaling
	fibroblast growth factor receptor signaling pathway
	negative regulation of cell growth
	positive regulation of protein serine-threonine kinase activity
	regulation of protein phosphorylation
	regulation of protein autophosphorylation
	regulation of transcription, DNA-dependent
	regulation of DNA replication
	negative regulation of epithelial to mesenchymal transition
	induction of apoptosis
	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
	RNA metabolic process
	mRNA metabolic process
	RNA splicing
	protein dephosphorylation
	ceramide metabolic process
	response to organic substance
	regulation of growth
	regulation of protein catabolic process
	mesoderm development
	gene expression
	protein heterotrimerization

Pathway	Cell Cycle
	adenosine monophosphate-activated protein kinase (AMPK) signaling pathway

Group	PP2A
	meiosis
	regulation of cell cycle
	regulation of receptor activity
	regulation of Wnt receptor signaling pathway
	negative regulation of tyrosine phosphorylation of Stat3 protein
	inactivation of MAPK activity
	regulation of cell differentiation
	regulation of cell adhesion
	second-messenger-mediated signaling
	fibroblast growth factor receptor signaling pathway
	negative regulation of cell growth
	positive regulation of protein serine-threonine kinase activity
	regulation of protein phosphorylation
	regulation of protein autophosphorylation
	regulation of transcription, DNA-dependent
	regulation of DNA replication
	negative regulation of epithelial to mesenchymal transition
	induction of apoptosis
	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
	RNA metabolic process
	mRNA metabolic process
	RNA splicing
	protein dephosphorylation
	ceramide metabolic process
	response to organic substance
	regulation of growth
	regulation of protein catabolic process
	mesoderm development
	gene expression
	protein heterotrimerization
	protein C-terminus binding
	protein heterodimerization activity
	metal ion binding
	hydrolase activity
	phosphoprotein phosphatase activity
	protein serine-threonine phosphatase activity
	membrane
	chromosome, centromeric region
	spindle pole
	protein phosphatase type 2A complex
	plasma membrane
	cytoplasm
	mitochondrion
	cytosol
	chromosome
	cytoskeleton
	microtubule cytoskeleton
	nucleus

MedScan ID	5515

Hugo ID	9299

Human chromosome position	5q31.1

Alias	RP-C
	PP2Ac
	PP2CA
	PP2Calpha
	serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
	PP2A-alpha
	replication protein C
	protein phosphatase 2A catalytic subunit, alpha isoform
	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
	serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
	PP2A
	R75353
	RP23-46N3.2
	protein phosphatase 2a, catalytic subunit, alpha isoform
	Pp2a1
	protein phosphatase-2A-alpha
	protein phosphatase 2, catalytic subunit, alpha isoform
	protein phosphatase 2 alpha
	protein phosphatase 2A alpha
	type-2A protein phosphatase catalytic subunit
	Pp2a I
	protein phosphatase 2, catalytic subunit, alpha isozyme
	OTTMUSP00000005798
	Ppp2ca
	agCP8121

OMIM ID	176915

EC Number	3.1.3.16

PIR ID	S01986
	S06592

Mouse chromosome position	11

Rat chromosome position	10q22

Homologene ID	37660

MGI ID	1321159

RGD ID	3380

Primary Cell Localization	Cytoplasm