| URN | urn:agi-llid:5834 |
|---|---|
| Connectivity | 18 |
| Name | Pygb |
| Description | phosphorylase, glycogen; brain |
| Notes | The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. |
| Pathway | glycogen degradation pathway |
|---|
| GO Molecular Function | drug binding |
|---|---|
| transferase activity | |
| sugar binding | |
| pyridoxal phosphate binding | |
| protein homodimerization activity | |
| transferase activity, transferring glycosyl groups | |
| phosphorylase activity | |
| glycogen phosphorylase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm | |
| axon |
| GO Biological Process | glycogen metabolic process |
|---|---|
| glycogen catabolic process | |
| carbohydrate metabolic process |
| Ariadne Ontology | Glycogen degradation |
|---|
| Group | Glycogen degradation |
|---|---|
| glycogen metabolic process | |
| glycogen catabolic process | |
| carbohydrate metabolic process | |
| drug binding | |
| transferase activity | |
| sugar binding | |
| pyridoxal phosphate binding | |
| protein homodimerization activity | |
| transferase activity, transferring glycosyl groups | |
| phosphorylase activity | |
| glycogen phosphorylase activity | |
| soluble fraction | |
| cytoplasm | |
| axon |
| MedScan ID | 5834 |
|---|
| Hugo ID | 9723 |
|---|
| Human chromosome position | 20p11.2-p11.1 |
|---|
| LocusLink ID | 5834 |
|---|---|
| 110078 | |
| 25739 |
| Alias | MGC9213 |
|---|---|
| RP5-965G21.1 | |
| glycogen phosphorylase, brain form | |
| glycogen phosphorylase B | |
| MGC36329 | |
| RP23-241M12.1 | |
| OTTMUSP00000016797 | |
| GLYPHOA | |
| brain glycogen phosphorylase | |
| Glycogen phosphorylase, brain | |
| GLYPHOAs | |
| LOC207396 | |
| OTTHUMP00000030488 | |
| phosphorylase, glycogen; brain | |
| PYGB | |
| phosphorylase | |
| polyphosphorylase | |
| potato phosphorylase | |
| starch phosphorylase | |
| 1,4-alpha-glucan phosphorylase | |
| alpha-glucan phosphorylase | |
| amylopectin phosphorylase | |
| phosphorylase, glycogen | |
| maltodextrin phosphorylase | |
| amylophosphorylase | |
| glucan phosphorylase | |
| muscle phosphorylase | |
| muscle phosphorylase a | |
| muscle phosphorylase b | |
| phosphorylase, glycogen, brain | |
| granulose phosphorylase | |
| 1,4-alpha-glucan phosphorylases | |
| alpha-glucan phosphorylases | |
| amylopectin phosphorylases | |
| amylophosphorylases | |
| glucan phosphorylases | |
| glucosan phosphorylases | |
| maltodextrin phosphorylases | |
| muscle phosphorylases | |
| phosphorylases | |
| polyphosphorylases | |
| potato phosphorylases | |
| starch phosphorylases | |
| granulose phosphorylases | |
| glucosan phosphorylase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138550 |
|---|
| Mouse chromosome position | 2 84.0 cM |
|---|
| GO ID | 0008144 |
|---|---|
| 0008184 | |
| 0042803 | |
| 0030170 | |
| 0005529 | |
| 0016757 | |
| 0005975 | |
| 0005980 | |
| 0030424 | |
| 0005737 | |
| 0005625 | |
| 0004645 | |
| 0016740 | |
| 0005977 | |
| 0003824 |
| Rat chromosome position | 3q41 |
|---|
| Swiss-Prot Accession | P11216 |
|---|---|
| Q59GM9 | |
| Q5JWL9 | |
| Q8TDG6 | |
| A2AWQ5 | |
| Q8CI94 | |
| Q3TFQ8 | |
| Q3UGT5 | |
| Q3UYH9 | |
| Q3UZL2 | |
| Q3V3U0 | |
| P53534 | |
| Q8K283 | |
| Q96AK1 | |
| Q9NPX8 |
| PIR ID | S37300 |
|---|---|
| A40138 |
| Unigene ID | Hs.368157 |
|---|---|
| Hs.657463 | |
| Mm.222584 | |
| Rn.1518 |
| KEGG ID | hsa:5834 |
|---|---|
| mmu:110078 | |
| rno:25739 |
| EC Number | 2.4.1.1 |
|---|
| Swiss-Prot ID | PYGB_RAT |
|---|---|
| PYGB_MOUSE | |
| PYGB_HUMAN | |
| A2AWQ5_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00948869 |
|---|---|
| IPI00229796 | |
| IPI00004358 | |
| IPI00789185 | |
| IPI00357945 |
| Homologene ID | 100930 |
|---|
| RGD ID | 3460 |
|---|
| MGI ID | 97828 |
|---|